Choriocarcinoma in the male patient presenting as gastrointestinal hemorrhage

Saliba, Nicholas S.; Sawyer, Kenneth C.; Hall, Wesley W.; Sawyer, Robert B.; Proctor, Hobart M.; Shand, JA

doi:10.1016/0002-9610(66)90120-6

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…Vol. 27 chorionic gonadotropins after institution of triple therapy was unchanged from the initial elevated values. On the forty-first hospital day, the chemotherapy was discontinued because of bone marrow suppression.…”

Section: Cancer March 1971mentioning

confidence: 72%

“…It could be anticipated that this rapidly growing and often necrotic tumor would cause bleeding from any mucosal sitc along the gastrointestinal tract. Several of the cases with small intestinal metastases have had significant gastrointestinal bleeding, [27][28][29] al. described a case in which hematemesis from a pancreatic rest of the stomach called attention to a retroperitoneal choriocarcinoma.27 Twice, hematemesis was an impressive and life-threatening occurrence in our patient, requiring radiation of the esophageal lesion to control the bleeding.…”

Section: Discussionmentioning

confidence: 99%

“…27 al. described a case in which hematemesis from a pancreatic rest of the stomach called attention to a retroperitoneal choriocarcinoma.27 Twice, hematemesis was an impressive and life-threatening occurrence in our patient, requiring radiation of the esophageal lesion to control the bleeding.…”

Section: Cancer March 1971mentioning

confidence: 98%

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Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion

McKechnie

Fechner

1971

Cancer

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A 44‐year‐old man died of disseminated choriocarcinoma. The esophagus was verified as the apparent primary source at postmortem examination. The esophageal tumor, but not the metastases, also contained well‐differentiated adenocarcinoma. Similar cases of mixed adenocarcinoma and choriocarcinoma have been reported to occur in the stomach. We believe that the basic lesion was an adenocarcinoma which underwent metaplasia to form cells morphologically and functionally indistinguishable from trophoblasts. This explanation would supplant the traditional idea of “embryonic rests” as the source of extragenital choriocarcinomas of the viscera. The literature is reviewed on the uncommon involvement of the gastrointestinal tract by choriocarcinoma.

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Section: Cancer March 1971mentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion

McKechnie

Fechner

1971

Cancer

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“…Laparotomy revealed a solitary gastric metastasis of testicular origin, gastrectomy was followed by survival for twelve years. Salika (1966) reported the case of a chorion carcinoma presenting with gastrointestinal haemorrhage. The left testicle was clinically absent and on laparotomy multiple hepatic deposits were found and a large mass in the stomach.…”

Section: Discussionmentioning

confidence: 99%

Testicular tumour presenting as haematemesis

Lock

1975

Postgraduate Medical Journal

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Hematogenous metastases to the stomach. A review of 67 cases

Green

1990

Cancer

135

105

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Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically evaluated presented with upper gastrointestinal tract symptoms, including bleeding, abdominal pain, anorexia, and vomiting. At endoscopic examination, characteristic "volcano-like" ulcers were noted. Clinical gastrointestinal symptoms were present in 30 of the necropsy cases, and in four cases the gastric metastases led to the patients' deaths. Tumors primary in the lung accounted for most of the metastases (55%), followed by other gastrointestinal malignancies. A correct diagnosis is important to direct therapy and is facilitated by the characteristic clinical, endoscopic, and histologic findings. Cancer 65:1596-1600,1990. LOOD-BORNE metastatic involvement of the gastricB mucosa by tumor is a rare occurrence according to the number of reports in the literature. Usually, the tumors most commonly reported to metastasize to the stomach include melanoma, breast carcinoma, and lung carcinoma. With a correct diagnosis and proper treatment, relief of symptoms and prolongation of life can sometimes be achieved.To determine the incidence of metastases to the stomach and the relationship between histologic type of neoplasm and the presence of stomach metastases, we recently reviewed endoscopic gastric biopsies and necropsies with malignancy over a 25-year period. Our results suggest that metastases to the stomach are uncommon but not as rare as previously reported and can be difficult to diagnose clinically. Materials and MethodsTen patients with neoplasms metastatic to the gastric mucosa were identified from a review of 260 gastric endoscopic biopsies with nonhematologic malignancies at Accepted for publication October 17, 1989 the Houston Veteran's Administration Medical Center. Fifty-seven patients with gastric mucosa metastases were identified in 1,951 necropsies of patients with nonhematologic malignancies. Lymphomas and leukemias were excluded from the study. Gastric metastases were defined as lesions secondarily involving the gastric mucosa by hematogenous spread. Cases with secondary involvement of the stomach by direct invasion from a contiguous neoplasm (ie., pancreas) or "seeding" of the peritoneal cavity through ascites ( i e . , ovary) were excluded. All available reports and slides were carefully studied as to histologic nature of the primary tumor, anatomic location, symptoms, and clinical presentation.Of the 67, the patients consisted of 65 men and two women with an average age of 58 years, which reflected the Veterans Administration Medical Center population. The findings therefore are skewed because of a significant preponderance of men in the study.

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Choriocarcinoma in the male patient presenting as gastrointestinal hemorrhage

Cited by 9 publications

References 4 publications

Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion

Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion

Testicular tumour presenting as haematemesis

Hematogenous metastases to the stomach. A review of 67 cases

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