Choriocarcinoma presenting as a breast lump

Fowler, Clare; Nicholson, S.; Lott, M.; Barley, V.

doi:10.1016/s0748-7983(95)97675-2

Cited by 14 publications

(15 citation statements)

References 8 publications

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“…However, acomponent of primary breast cancer, such as breast-infiltrating ductal carcinoma and/or ductal carcinoma in situ, could be commonly found in BCCF. Further, a positive staining of GCDFP-15 in BCCF also supports that BCCF is a primary breast cancer [10,13]. Although our case presented with a component of poor differentiated carcinoma without any component of breast ductal carcinoma, other evidence supports the diagnosis of BCCF: an immunohistochemical profile of GCDFP-15 (+), CK7 (+), CK20 (-), CK (+), CK5(-), EMA (+), 32-year-old female with regular menstruation and no history of reproductive system tumors,and no pregnancy during disease occurrence.…”

Section: Discussionmentioning

confidence: 86%

Breast carcinoma with choriocarcinomatous features: a case report and review of the literature

Zhu

Liu

et al. 2014

World J Surg Onc

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BackgroundBreast carcinoma with choriocarcinomatous features (BCCF) is a rare variant of breast cancer, characterized by high expression of human chorionic gonadotropin (HCG) in cancer cells such as multinucleated syncytiotrophoblast-like giant cells. The first case of BCCF was reported in 1981 by Saigo and Rosen. Only one case of BCCF was reported to show no component of breast ductal carcinoma, and only partially cancer cells, such as multinucleated syncytiotrophoblast-like giant cells, expressed HCG in all previous BCCF cases. Here, we report the first BCCF case without any component of breast ductal carcinoma in which HCG was found to express in all cancer cells.Case presentationA 32-year-old female patient presented with a small lump in her left breast 3 years prior. The mass was clinically suspected to be breast infiltrating ductal carcinoma based on breast excisional biopsy and magnetic resonance imaging findings. Due to rupture and bleeding of the left kidney, the left kidney excisional biopsy was performed. After a retrospective analysis of the initial excised breast cancer and breast cancer metastatic to the kidney, the cancer cells were positive for HCG by immunohistochemistry, and multinucleated or mononucleated giant cells resembled syncytiotrophoblastic and cytotrophoblastic cells which could be seen in a background of poor differentiated breast carcinoma and extensive necrosis and hemorrhage in the lesion. Thus, a final diagnosis of BCCF and BCCF metastatic to the kidney was made. After combination of surgical resection (the affected left breast and left kidney wereremoved) and consecutive chemotherapy consisting of docetaxel, epirubicin, cisplatin, lobaplatin, and capecitabine, the patient achieved favorable therapeutic efficacy (the HCG level returned to normal values, the metastatic lesions in the lungs disappeared, and the survival was 37 months). Capecitabine was very efficient and highly recommended due to its superior efficacy in reducing the HCG level and eliminating the metastatic lesions in the lungs.ConclusionsThis is the first report of a rare case of BCCF without any component of breast ductal carcinoma, featured by high expression of HCG in all cancer cells. Combination of surgery and chemotherapy (especially capecitabine) achieved a favorable therapeutic efficacy.

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Section: Discussionmentioning

confidence: 86%

Breast carcinoma with choriocarcinomatous features: a case report and review of the literature

Zhu

Liu

et al. 2014

World J Surg Onc

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“…Les sarcomes, et plus particulièrement les leiomyosarcomes, donnent rarement des métastases mammaires, à notre connaissance seulement neuf cas ont été publiés dont quatre cas étaient d'origine utérine [1,3,4,14,16,18,19]. Le choriocarcinome est également rarement à l'origine de métastase mammaire, en effet seulement dix cas ont été déjà rapportés [3,12,13,[20][21][22], dans un seul cas la méta-stase était révélatrice du choriocarcinome [21]. La plus large série de tumeurs neuroendocrine secondaires du sein est rapporté par Upalakalin et al [15] incluant 24 cas, dont neuf cas la métastase mammaire était révélatrice de la tumeur primitive.…”

Section: Discussionunclassified

Les métastases mammaires : étude anatomoclinique de six cas

Charfi

Makni

Khanfir

et al. 2008

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…4,[7][8][9]12,13,15,16 Choriocarcinoma metastatic to the breast has been reported in 6 cases. 1,8,10,11,14,17 The cytologic diagnosis of choriocarcinoma metastatic to the breast has been reported in only 1 case, in a patient who had a previous history of uterine choriocarcinoma. 11 In contrast, the patient described in this report was noted to have a previous history of hydatidiform mole only after a histologic diagnosis of a metastatic choriocarcinoma in the nasal cavity during evaluation of the associated lung and breast masses.…”

Section: Discussionmentioning

confidence: 99%

“…1,8,10,14,17 To our knowledge, FNAC of a choriocarcinoma metastatic to the breast has been reported in only 1 case in the English-language literature and occurred in a patient with a previous history of uterine choriocarcinoma. 11 Although choriocarcinoma is a rapidly invasive, widely metastasizing malignancy, it responds well to chemotherapy, so an early diagnosis is important.…”

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confidence: 95%