Chorioretinal lesions in nonfatal cases of West Nile virus infection

Hershberger, Vrinda; Augsburger, James J.; Hutchins, Robert K.; Miller, Steven A.; Horwitz, Jeffrey A; Bergmann, M

doi:10.1016/s0161-6420(03)00720-6

Cited by 63 publications

(40 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5][6][7] Such a chorioretinitis appears to be a specific marker of the disease, particularly in patients who present with meningoencephalitis. 8 The distribution of chorioretinal lesions have been described as scattered throughout the fundus or in linear streaks.…”

Section: Introductionmentioning

confidence: 99%

Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization

Khairallah

Yahia

Attia

et al. 2006

Eye

View full text Add to dashboard Cite

Purpose To clarify the reason for the linear pattern of West Nile virus (WNV)-associated chorioretinitis. Methods The study included 12 patients (24 eyes) with WNV-associated chorioretinitis. All the patients underwent a complete ophthalmic evaluation, including dilated fundus examination, fundus photography, fluorescein angiography, and indocyanine green angiography. Characteristics of linear streaks, particularly their relationship to the course of retinal and choroidal vessels, and pattern of retinal nerve fibres, were analysed. Results All patients had bilateral multifocal chorioretinitis with linear clustering of chorioretinal lesions associated with a variable number of scattered lesions. Linear streaks, variable in number and length, originated from the optic disc or its vicinity in most cases. Their course in all cases appeared to closely follow the course of retinal nerve fibres, rather than that of retinal or choroidal vessels. Conclusions Results of our study show that the linear pattern of WNV-associated chorioretinitis is related to retinal nerve fibres organization, suggesting a contiguous spread of WNV virus from central nerve system via the optic nerve fibres to the outer retina, retinal pigment epithelium, and choroid. Eye (2007) 21, 952-955;

show abstract

Section: Introductionmentioning

confidence: 99%

Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization

Khairallah

Yahia

Attia

et al. 2006

Eye

View full text Add to dashboard Cite

show abstract

“…Lesions tend to be clustered primarily in the temporal and nasal regions of the periphery of the fundus. This distribution and appearance of the chorioretinal lesions have been suggested to be distinctive for WN virus infection [98]. Such lesions have been reported to be present in up to 69% of persons presenting with WN virus illness [102], and to be helpful in the diagnosis of WN virus infection; thus, detailed ophthalmoscopic examination is encouraged in all cases of suspected WN virus infection.…”

Section: West Nile Choreoretinitismentioning

confidence: 93%

“…Ocular manifestations including chorioretinitis and vitritis are among the more commonly reported WN virus-associated syndromes [98][99][100][101]. The chorioretinal lesions associated with WN virus infection have been described as multifocal and with a 'targetlike' appearance [98]; retinal hemorrhages have been noted.…”

Section: West Nile Choreoretinitismentioning

confidence: 99%

See 1 more Smart Citation

Manifestations of West Nile neuroinvasive disease

Sejvar

Marfin²

2006

Rev. Med. Virol.

View full text Add to dashboard Cite

Since its introduction to North America in 1999, West Nile virus, an arthropod-borne flavivirus, has become the most significant cause of epidemic encephalitis in the western hemisphere. While most human infections with the virus are asymptomatic and the majority of symptomatic persons experience febrile illness, severe neurologic manifestations, including meningitis, encephalitis, and poliomyelitis may be seen. This review summarizes the virology, epidemiology and pathogenesis of human infection with West Nile virus, and details recent advances in our understanding of the pathophysiology and various clinical manifestations of infection.

show abstract

“…Since the first descriptions of ocular involvement secondary to WNV infection in 2002 and 2003, several ophthalmologic findings have been recognized, including chorioretinitis, anterior uveitis, retinal vasculitis, optic neuritis, and congenital chorioretinal scarring [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

Section: Ocular Diseasementioning

confidence: 99%

Novel infectious agents causing uveitis

et al. 2009

View full text Add to dashboard Cite

In any patient with uveitis, an infectious cause should be ruled out first. The differential diagnosis includes multiple well-known diseases including herpes, syphilis, toxoplasmosis, tuberculosis, bartonellosis, Lyme disease, and others. However, clinician should be aware of emerging infectious agents as potential causes of systemic illness and also intraocular inflammation. Air travel, immigration, and globalization of business have overturned traditional pattern of geographic distribution of infectious diseases, and therefore one should work locally but think globally. This review recapitulates the systemic and ocular manifestations of several emergent infectious diseases relevant to the ophthalmologist including Rickettsioses, West Nile virus infection, Rift valley fever, Dengue fever, and Chikungunya. Retinitis, chorioretinitis, retinal vasculitis, and optic nerve involvement have been associated with these emergent infectious diseases. The diagnosis of any of these infections is usually based on pattern of uveitis, systemic symptoms and signs, and specific epidemiological data and confirmed by detection of specific antibody in serum. A systematic ocular examination, showing fairly typical fundus findings, may help establish an early clinical diagnosis, which allows prompt, appropriate management.

show abstract

Chorioretinal lesions in nonfatal cases of West Nile virus infection

Cited by 63 publications

References 7 publications

Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization

Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization

Manifestations of West Nile neuroinvasive disease

Novel infectious agents causing uveitis

Contact Info

Product

Resources

About