Choristoma of the Optic Nerve and Chiasm

Kazim, Michael; Kennerdell, John S.; Maroon, Joseph C.; Rothfus, William E.; Marquardt, Merlin D.

doi:10.1001/archopht.1992.01080140092034

Cited by 28 publications

(8 citation statements)

References 2 publications

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“…The summary of these neuroradiological characteristics correlated with previous reports on choristomas of the optic nerve and made diagnosis possible, although the patient refused surgery and biopsy. MRI was reported to be not specific in a previous report using conventional spin echo sequences [2]. The use of chemical shift-specific frequency-selective fat saturation sequences in our patient enabled MRI to establish the unequivocal diagnosis of the fatty nature of the tumor.…”

Section: Discussionmentioning

confidence: 65%

“…It is characterized by the presence of heterotopic mesodermal tissue [1, 2], which, mostly present in microscopic amounts, may account for the gross enlargement of the optic nerve. Histological characteristics of choristomas are adult fat cells, intermingled with small amounts of other tissue elements, such as fibrous tissue and smooth muscles [1, 2]. The occurrence of heterotopic mesodermal elements has also been reported in other malformations of the optic nerve [4, 5].…”

Section: Discussionmentioning

confidence: 99%

“…Despite progressive visual loss, surgical treatment is problematic because of the likelihood of total visual loss due to excision [2]. Radiotherapy may not be recommended in some patients either because of their young age [2].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, conventional neuroimaging methods failed in the past to adequately characterize rare tumors of the optic nerve such as choristomas. Surgical exploration and subsequent histological investigation, which can be very harmful for the vision of these patients, was therefore required in a number of cases [1, 2]. Improvement of the neuroimaging technique during the last few years permits improvement of characterization of the neurovascular orbital tissue [3].…”

Section: Introductionmentioning

confidence: 99%

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Choristoma of the Optic Nerve: Neuroimaging Characteristics and Association with Spinal Cord Lipoma

Daxer

Sailer²,

Ettl

et al. 1998

Ophthalmologica

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A 54-year-old patient presented with amaurosis of the right eye that resulted from a dysontogenetic tumor of the right optic nerve. The tumor involved the intraorbital, intracanalicular and intracerebral portion of the right optic nerve, without involvement of the chiasm. Although the patient had refused further diagnostic surgical exploration, we show that it is possible to establish the diagnosis of choristoma of the optic nerve by means of modern neuroimaging techniques based on computed tomography and magnetic resonance imaging. It appears from neuroimaging that choristomata of the optic nerve and spinal cord lipomas represent different manifestations of the same type of tumor. The neuroimaging characteristics of both kinds of tumors are discussed.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Choristoma of the Optic Nerve: Neuroimaging Characteristics and Association with Spinal Cord Lipoma

Daxer

Sailer²,

Ettl

et al. 1998

Ophthalmologica

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“…They include hemangioblastoma, hemangiopericytoma, choristoma (which is a rare benign tumor, containing fat and smooth muscle [28]), metastasis, and extension to the nerve of an intraocular tumor (melanoma and retinoblastoma). Nontumoral enlargement of the optic nerve is also observed in many other conditions.…”

Section: Optic Nerve Gliomamentioning

confidence: 99%

Imaging of the normal and pathological orbit

Duvoisin

Zanella²,

Sievers

1998

Eur Radiol

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Computerized techniques (CT and MRI) allow precise delineation of orbital anatomy and abnormalities. Orbital tumors are nicely depicted by these methods; various examples are illustrated in this article, with discussion of the respective impact of CT and MRI. Orbital inflammation and foreign bodies usually represent radiologic emergencies, prompting use of CT (frequently) or MRI (occasionally). Digital subtraction angiography (DSA) is indicated for diagnosis of vascular changes (mainly carotid-cavernous fistula, aneurysms, angiomas, Rendu-Osler disease). Angiography is usually done to ascertain the possibility of an interventional procedure. Orbital vascular interventions include re-canalization of occluded vessels, and embolization of pathologic (tumorous or post-traumatic) vessels.

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The Orbit: Biopsy, Excision Biopsy, and Exenteration Specimens

Roberts

Thum

2013

Lee's Ophthalmic Histopathology

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Choristoma of the Optic Nerve and Chiasm

Cited by 28 publications

References 2 publications

Choristoma of the Optic Nerve: Neuroimaging Characteristics and Association with Spinal Cord Lipoma

Choristoma of the Optic Nerve: Neuroimaging Characteristics and Association with Spinal Cord Lipoma

Imaging of the normal and pathological orbit

The Orbit: Biopsy, Excision Biopsy, and Exenteration Specimens

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