Choroid plexectomy for the treatment of chronic infected hydrocephalus

Lapras, C; Mertens, Patrick; Guilburd, Joseph N.; Pialat, J; Patet, J. D.

doi:10.1007/bf00270903

Cited by 35 publications

(17 citation statements)

References 6 publications

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“…A small series of 17 patients with "chronic hydrocephalus" underwent primary choroid plexectomy; the authors reported a 37% success rate, defined as avoidance of CSF-diversion procedures. 81 Subsequent small series in selected patients who underwent either CPC or plexectomy found advantages in terms of reduced rates of reoperation, readmission, or operative complications. 92,144 The underlying motif for these reports points to adequate patient selection as a key determinant in maximizing the chances of shunt avoidance when performing isolated choroid plexus-disruption procedures.…”

Section: Modulation Of Csf Secretion By Surgical Intervention Of the mentioning

confidence: 99%

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Karimy¹,

Durán²,

Hu³

et al. 2016

FOC

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Hydrocephalus, despite its heterogeneous causes, is ultimately a disease of disordered CSF homeostasis that results in pathological expansion of the cerebral ventricles. Our current understanding of the pathophysiology of hydrocephalus is inadequate but evolving. Over this past century, the majority of hydrocephalus cases has been explained by functional or anatomical obstructions to bulk CSF flow. More recently, hydrodynamic models of hydrocephalus have emphasized the role of abnormal intracranial pulsations in disease pathogenesis. Here, the authors review the molecular mechanisms of CSF secretion by the choroid plexus epithelium, the most efficient and actively secreting epithelium in the human body, and provide experimental and clinical evidence for the role of increased CSF production in hydrocephalus. Although the choroid plexus epithelium might have only an indirect influence on the pathogenesis of many types of pediatric hydrocephalus, the ability to modify CSF secretion with drugs newer than acetazolamide or furosemide would be an invaluable component of future therapies to alleviate permanent shunt dependence. Investigation into the human genetics of developmental hydrocephalus and choroid plexus hyperplasia, and the molecular physiology of the ion channels and transporters responsible for CSF secretion, might yield novel targets that could be exploited for pharmacotherapeutic intervention.

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Section: Modulation Of Csf Secretion By Surgical Intervention Of the mentioning

confidence: 99%

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

Karimy¹,

Durán²,

Hu³

et al. 2016

FOC

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“…-Introduction), and according to the experimental results obtained that way, it seemed logical that the removal of the choroid plexuses (if the CSF pathways are blocked) should result in preventing the development of hydrocephalus, and in the recovery and healing of the patients as well. For many years, this surgical procedure was the most popular form of hydrocephalus treatment, but because of universally poor results, it has no place in the current treatment of hydrocephalus (Lapras et al, 1988;Milhorat, 1976; see Section 7.1. -Choroid plexectomy).…”

Section: Controversy Between Hydrocephalus and The Classical Hypothesismentioning

confidence: 99%

“…However, over the decades it became clear that bilateral extirpation and/or cauterization of the choroid plexuses invariably failed to benefit the patients. As was mentioned, because of universally unsatisfactory results, choroid plexectomy was abandoned by neurosurgeons as a treatment for hydrocephalus, so today it is an operation of historic interest only, and has no place in the treatment of hydrocephalus (Lapras et al, 1988;Milhorat, 1976). Despite these discouraging results, the introduction of the endoscopic method renewed an interest in different surgical procedures on the choroid plexuses, especially in the mid 90s (Enchev and Oi, 2008;Pople and Ettles 1995;Wellons et al, 2002).…”

Section: Choroid Plexectomymentioning

confidence: 99%

Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: Facts and illusions

Orešković

Klarica

2011

Progress in Neurobiology

126

111

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“…Scarff, however, continued to advocate choroid plexectomy and Dandy's later technique of third ventriculostomy as the simplest and most physiological methods of surgical treatment. This method of treatment (endoscopic coagulation) has been revived more recently for use in certain subgroups of hydrocephalic children [18][19][20].…”

Section: Hydrocephalus In Ancient Historymentioning

confidence: 99%