Choroid plexus tumors: A clinico-pathological and neuro-radiological study of 23 cases

Abstract

Background:Choroid plexus tumors are intraventricular tumors derived from choroid plexus epithelium.Aim:To study the choroid plexus tumors with reference to their clinical, radiological, and pathological features.Materials and Methods:The study was performed by the retrospectively reviewing the clinical, radiological, and pathological records of patients of choroid plexus tumors.Results:A total of 23 cases (11 males, 13 females) of choroid plexus tumor were diagnosed from 1997 to 2009. Fourteen patients were below 15 years of age. Raised intracranial pressure was the main presenting feature in all the cases. Tumor was located in lateral ventricle (n = 14; in 3 cases tumor was going into third ventricle), fourth ventricle (n = 7), and cerebellopontine angle (n = 2). Total tumor excision was achieved in 21 cases. The histopathology was suggestive of choroid plexus papilloma (n = 19), atypical choroid plexus papilloma (n = 1), and choroid plexus carcinoma (n = 2). Clears cell areas were noted in three cases. Other histopathological features observed were foci of calcification (n = 5), Psammoma bodies (n = 2), hemorrhage (n = 5), hyalinization (n = 2), and oncocytic changes (n = 1).Conclusions:Choroid plexus tumors are intraventricular tumors arising from choroid plexus epithelium. The predominant clinical presentation is raised intracranial pressure. Surgery is the mainstay of treatment; histopathologically, they include choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma.

Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children

“…It is unclear whether propensity of CNS sarcomas to spontaneously bleed could be related to vascular proliferation as observed in choroid plexus tumors. 6,8 The cell of origin of these tumors may shed some light on their apparent increased risk of hemorrhage. McDonald et al suggest that sarcomas arising from within the brain parenchyma presumably find their origin from mesenchymal cells associated with the vascular adventitia.…”

Severe Meningeal Calcification in a Crouzon Patient Carrying a Mutant C342W FGFR2

“…For choroid plexus tumors (intraventricular tumors), raised intracranial pressure was its predominant presenting feature and might be associated to foci of calcification. 8 For ischemic stroke, an increase in vascular resistance was correlated with the severity of intracranial artery calcification. 9 On the basis of the observations, the cranial pressure could result in calcifications.…”

Primary cerebellopontine angle choroid plexus papilloma in a child: A rare occurrence

“…[1] Primary CPP of the cerebellopontine (CP) angle is very rare. [2][3][4] We report a young child with primary CPP in the CP angle.…”