Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt–Koyanagi–Harada Disease Using Swept-Source Optical Coherence Tomography

Jaisankar, Durgasri; Raman, Rajiv; Sharma, Hitesh; Khandelwal, Neha; Bhende, Muna; Agrawal, Rupesh; Sridharan, Sridha; Biswas, Jyotirmay

doi:10.1080/09273948.2017.1332231

Cited by 31 publications

(23 citation statements)

References 30 publications

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“…A retrospective study on 19 eyes with VKH documented a higher CVI in the acute stage and reduction after treatment [32]. These results were confirmed by another prospective study [33]. The increased CVI was interpreted as an indirect indicator of stasis of blood flow within the choroid due to impaired choroidal circulation [32,33].…”

Section: In Inflammatory Chorioretinal Disordersmentioning

confidence: 78%

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Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Iovino

Pellegrini

Bernabei

et al. 2020

JCM

168

128

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Remarkable improvements in optical coherence tomography (OCT) technology have resulted in highly sophisticated, noninvasive machines allowing detailed and advanced morphological evaluation of all retinal and choroidal layers. Postproduction semiautomated imaging analysis with dedicated public-domain software allows precise quantitative analysis of binarized OCT images. In this regard, the choroidal vascularity index (CVI) is emerging as a new imaging tool for the measurement and analysis of the choroidal vascular system by quantifying both luminal and stromal choroidal components. Numerous reports have been published so far regarding CVI and its potential applications in healthy eyes as well as in the evaluation and management of several chorioretinal diseases. Current literature suggests that CVI has a lesser variability and is influenced by fewer physiologic factors as compared to choroidal thickness. It can be considered a relatively stable parameter for evaluating the changes in the choroidal vasculature. In this review, the principles and the applications of this advanced imaging modality for studying and understanding the contributing role of choroid in retinal and optic nerve diseases are discussed. Potential advances that may allow the widespread adoption of this tool in the routine clinical practice are also presented.

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Section: In Inflammatory Chorioretinal Disordersmentioning

confidence: 78%

“…Four studies evaluated CVI in Vogt-Koyanagi-Harada (VKH) disease, reporting conflicting results [32][33][34][35]. A retrospective study on 19 eyes with VKH documented a higher CVI in the acute stage and reduction after treatment [32].…”

Section: In Inflammatory Chorioretinal Disordersmentioning

confidence: 99%

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Iovino

Pellegrini

Bernabei

et al. 2020

JCM

168

128

View full text Add to dashboard Cite

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“…Swept-source optical coherence tomography (SS-OCT) uses a longer wavelength than spectral domain OCT, penetrates tissues better and enables us to visualise the choroid 3 . Choroidal changes are evaluated in various systemic 4 and ocular [5][6][7][8][9][10][11] disorders.…”

Section: Introductionmentioning

confidence: 99%

Changes in subfoveal choroidal thickness after uncomplicated cataract surgery

Gudauskienė¹,

Matulevičiūtė²,

Mockutė³

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Recent investigations show that phacoemulsification causing an inflammatory insult to the eye has an effect not only on retina but on the choroid as well. The purpose of this study was to evaluate the subfoveal choroidal thickness (SFCT) after uneventful phacoemulsification using swept-source optical coherence tomography (SS-OCT). Methods. This prospective study included 30 eyes of 23 patients with senile cataract undergoing uncomplicated phacoemulsification and intraocular lens implantation. SFCT and foveal retinal thickness (FRT) measurements were made at the same time, 1-2 PM preoperatively (P), 1 month (M1) and 3 months (M3) postoperatively using 1050 nm DRI Triton SS-OCT (Topcon, Tokyo, Japan). Postoperative changes in the SFCT, FRT and correlation of SFCT change with axial length, age, baseline intraocular pressure (IOP), IOP change were assessed. Results. The mean SFCT increased statistically significantly 3 months after surgery in all sectors except the superior inner region. Of the factors affecting the SFCT, the change in the SFCT (M3/P), correlation with age and baseline IOP in almost all sectors was observed. The mean FRT increased significantly after the surgery in all sectors. Conclusions. Insignificant subclinical increase in SFCT was observed 1 month after the cataract surgery. Significant increment in SFCT was detected 3 months postoperatively, which was correlated with surgery-induced IOP and ocular perfusion pressure change in the short term.

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“…Therefore, monitoring should guide the uveitis specialist to eradicate choroidal recurrence by increasing therapy each time there is significant choroidal subclinical inflammation [ 31 ]. Recent works have compared the utility of ICGA, EDI-OCT and SS-OCT during follow-up of patients with VKH disease [ 21 – 23 , 41 , 42 ]. ICGA is a technique using indocyanine green dye to visualize the choroid and delineate the choroidal circulation, giving an evaluation of inflammatory lesions in various conditions with high sensitivity [ 21 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…On the other hand, EDI-OCT and SS-OCT are a non-invasive, more affordable technique that are used to evaluate choroidal thickness and morphology, providing a detailed and objective visualization of the choroid, and thus can be used to characterize inflammatory activity in disorders involving the posterior segment [ 22 , 23 ]. In this regard, SS-OCT has been reported to be superior to EDI-OCT, presenting higher resolution and more measurable images, allowing in the same scan a precise qualitative and quantitative evaluation of retinal and choroidal changes [ 23 , 42 ]. ICGA has been described as more sensitive than EDI-OCT to detect disease recurrences or subclinical inflammation in VKH patients [ 21 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

Initial-onset acute and chronic recurrent stages are two distinctive courses of Vogt-Koyanagi-Harada disease

Urzua

Herbort

Valenzuela

et al. 2020

J Ophthal Inflamm Infect

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Purpose To describe distinctive stages of Vogt-Koyanagi-Harada (VKH) disease: initial-onset acute versus chronic recurrent disease. Methods A comprehensive literature review regarding stages and clinical presentations of VKH disease was conducted. Results Despite a list of signs that has been described as characteristic features of early or late phases of VKH disease, the current classification -developed by an international committee and published in 2001- does not consider a distinction regarding the time from onset of disease symptoms, and specific findings observed at certain time point from the symptoms presentation and outcomes related to the stage of VKH disease. In that sense, chronic recurrent VKH disease is more refractory to treatment and is associated with a higher rate of complications. Accordingly, this subset of VKH patients has poorer functional and anatomical outcomes than patients with an initial-onset acute disease. Conclusions An early clear distinction of VKH phenotype [Initial-onset acute versus chronic recurrent disease] should be considered in each clinical scenario, evaluating the delay in diagnosis and the clinical presentation, since it may help clinicians to perform a correct disease prognosis categorization and thus to make treatment decisions in terms of potential refractoriness or expected clinical outcomes.

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Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt–Koyanagi–Harada Disease Using Swept-Source Optical Coherence Tomography

Abstract: We have shown choroidal remodeling in VKH. SS-OCT can serve as an important noninvasive tool in assessment of treatment response in patients with VKH disease.

Cited by 31 publications

References 30 publications

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Changes in subfoveal choroidal thickness after uncomplicated cataract surgery

Initial-onset acute and chronic recurrent stages are two distinctive courses of Vogt-Koyanagi-Harada disease

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