Choroidal detachments: what do optometrists need to know?

Diep, M; Madigan, Michele C.

doi:10.1111/cxo.12807

Cited by 21 publications

(21 citation statements)

References 95 publications

(142 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have indicated that the permeability of microvessels is related to various inflammatory cytokines, such as IL-6, IL-8, chemokine monocyte chemoattractant protein 1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) [30]. Inflammation could be an important cause for some idiopathic UES [31]. Kumar et al [25] applied the indocyanine green chorioangiography (ICG) findings in two cases of UES to display focal areas of late-phase choroidal hyperfluorescence, which is suggestive of choroidal hyperpermeability.…”

Section: Discussionmentioning

confidence: 99%

“…Dvorak et al [30] confirmed that VEGF can enhance microvascular hyperpermeability, which could also be a factor that causes macular edema in various retinal vascular diseases, such as branch vein occlusion. It is known that anti-VEGF can reduce the hyperpermeability of choroidal vessels [31,32]. In the course of UES, if the hyperpermeability of choroidal vessels can be reduced, the suprachoroidal fluid may also decrease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report

Song

Fang

2021

J Med Case Reports

View full text Add to dashboard Cite

Background Uveal effusion syndrome is a rare disease characterized by exudative detachments of the choroid, ciliary body, and retina. Various surgical procedures and nonsurgical strategies have been described to treat uveal effusion syndrome with limited success. The treatment for uveal effusion syndrome remains a serious challenge for clinicians. To the best of our knowledge, no previous report has described a severe uveal effusion syndrome patient with nanophthalmos treated by using an anti-vascular endothelial growth factor agent alone. We report here one such case with unexpected positive results. Case presentation A 30-year-old Chinese male patient presented with painless vision loss in both eyes that had persisted for 2 months. Examination of the right eye revealed a best corrected visual acuity of 0.03; the best corrected visual acuity of the left eye was finger count/20 cm. The intraocular pressure was normal on both eyes. A-scan revealed an right eye axial length of 15.88 mm and a left eye axial length of 16.21 mm. In the right eye, half of the peripheral choroid and nearly three-fourths of the retina were detached. The left fundus was not visible because of the total retinal detachment located just behind the lens, which could be clearly observed directly with a slit lamp. Considering all the possibilities and available treatments as well as the patient’s intentions after discussion, we first administered an intravitreal injection of ranibizumab 0.5 ml into both eyes. The patient’s visual perception improved 3 days after the injection. One month later, most of the effusion under the choroid and retina was absorbed. Visual acuity improved from finger count to 0.05 in both eyes, and vision quality was remarkably improved. Encouraged by this good result, the patient opted to undergo a second injection 1 month later. Choroidal and retinal detachment completely vanished 30 days after the second injection. Conclusions Using an anti-vascular endothelial growth factor agent alone may be a potentially effective and safe method for managing some types of uveal effusion syndrome, such as in nanophthalmos. The injection may be administered before considering more aggressive procedures in some uveal effusion syndrome patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report

Song

Fang

2021

J Med Case Reports

View full text Add to dashboard Cite

show abstract

“…Therefore, physiological mechanisms such as vortex vein drainage, osmotic pressure, hydrostatic forces, and scleral vessels exist to maintain balance in protein and fluid levels. 1 , 2 , 3 When this equilibrium is disrupted, the blood vessels of the choriocapillaris become enlarged and hyperpermeable causing transudate and exudate to leak into the suprachoroidal space. 1 , 2 , 3 , 4 , 5 The process is exacerbated by ciliary body thickening, decreased aqueous production, and hypotony.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 , 3 When this equilibrium is disrupted, the blood vessels of the choriocapillaris become enlarged and hyperpermeable causing transudate and exudate to leak into the suprachoroidal space. 1 , 2 , 3 , 4 , 5 The process is exacerbated by ciliary body thickening, decreased aqueous production, and hypotony. 3 , 4 When arteriolar and venous pressure exceed the intraocular pressure (IOP), it favors additional leakage of fluid.…”

Section: Introductionmentioning

confidence: 99%

Hypotony maculopathy and choroidal detachment from repeated nocturnal ocular compression in a pediatric patient

Ditch

Bloom²,

Ellis

et al. 2022

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

“…Various drugs have been reported to induce angle-closure glaucoma and transient myopia [ 1 ]. Indapamide is one such drug.…”

Section: Introductionmentioning

confidence: 99%

Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report

et al. 2021

View full text Add to dashboard Cite

Background Indapamide, a sulfonamide diuretic used to treat hypertension, has been reported to have ocular side effects of acute angle-closure glaucoma, transient myopia and choroidal effusion whose immediate etiology is uncertain. This report aims to clarify the nature of indapamide-induced edema of the entire eyeball using multimodal imaging. Case presentation A 60-year-old woman who was following a long-term carbohydrate-restricted diet and receiving oral treatment for hypertension was referred to our department for eye pain. Indapamide (1 mg daily) was prescribed for uncontrolled hypertension 5 days before her visit; she took the medication for only 3 days and then stopped due to dry eye. However, she began to feel eye pain the day after her last dose, and the pain gradually intensified. She experienced no decrease in visual acuity at the initial visit; however, an extremely shallow anterior chamber was observed in both eyes, along with a slight increase in intraocular pressure. For differential diagnosis, ocular manifestations were evaluated with wide-field fundus photography, optical coherence tomography (OCT) of both anterior and posterior segments, fluorescein / indocyanine green angiography, ultrasound biomicroscopy and head magnetic resonance, showing edema of the entire eyeball. Treatment with tropicamide and phenylephrine hydrochloride drops resulted in rapid recovery of the anterior chamber depth and disappearance of the choroidal effusion within 3 days. Conclusions Multimodal imaging is useful for diagnosing drug-induced choroidal effusion by evaluating ocular conditions before and after treatment.

show abstract

Choroidal detachments: what do optometrists need to know?

Cited by 21 publications

References 95 publications

Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report

Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report

Hypotony maculopathy and choroidal detachment from repeated nocturnal ocular compression in a pediatric patient

Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report

Contact Info

Product

Resources

About