Choroidal granuloma as an initial manifestation of systemic sarcoidosis

Verma, Aditya; Biswas, Jyotirmay

doi:10.1007/s10792-009-9328-5

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…Choroidal granulomas manifesting as the sole lesion in ocular sarcoidosis has been previously described [1,7-10]. Desai et al reported on the largest case series of choroidal granulomas in nine patients with biopsy-proven sarcoidosis [1].…”

Section: Discussionmentioning

confidence: 99%

Multimodal imaging of sarcoid choroidal granulomas

Modi

Epstein

Bhaleeya

et al. 2013

J OPHTH INFLAMM INFECT

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BackgroundEnhanced-depth imaging optical coherence tomography (EDI-OCT) provides high-resolution imaging of the choroid. Herein, we report multimodal imaging, including EDI-OCT, of a case of sarcoid choroidal granulomas.FindingsA 63-year-old female with biopsy-supported sarcoidosis presented with unilateral multifocal choroidal granulomas. Enhanced-depth imaging optical coherence tomography (EDI-OCT) demonstrated a homogenous hyporeflective choroidal lesion with choriocapillaris thinning and sparing of the surrounding choroid. The patient was started on oral steroids with a weekly taper schedule. Within 5 weeks, the choroidal lesions had clinically resolved with return of normal-appearing choroidal architecture on EDI-OCT. Indocyanine green angiography, however, demonstrated hypofluoresence at the sites of choroidal granulomas 11 months after the clinical resolution, suggesting a longstanding choroidal perfusion deficit undetected by OCT.ConclusionsChoroidal imaging via EDI-OCT provides detailed morphologic information of sarcoid granulomas and can accurately demonstrate structural resolution of the lesions.

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Section: Discussionmentioning

confidence: 99%

Multimodal imaging of sarcoid choroidal granulomas

Modi

Epstein

Bhaleeya

et al. 2013

J OPHTH INFLAMM INFECT

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“…On EDI-OCT, Choroidal granulomas appeared as hyporeflective thickening of the choroid [26–28]. On FA, the lesions can demonstrate hypofluorescence, isofluorescence, early blocking with late staining, and hyperfluorescence [26, 29, 30]. Many reports have described the choroidal granulomas as hypofluorescent on ICGA [28, 31].…”

Section: Main Textmentioning

confidence: 99%

Multi-modal imaging and anatomic classification of the white dot syndromes

et al. 2017

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The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The “white dot syndromes” and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis. Neoplastic and infectious etiologies are also discussed given their ability to masquerade as WDS.

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“…This was around 95% in those who presented to the tertiary eye care center probably due to the referral bias [9]. Ocular manifestations include uveitis, dry eye, conjunctival granulomas, and involvement of the orbit and optic nerve [9,10,18-21,34]. …”

Section: Reviewmentioning

confidence: 99%

Sarcoidosis in tuberculosis-endemic regions: India

Babu¹

2013

J OPHTH INFLAMM INFECT

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology affecting multiple organs. Earlier reports suggested that sarcoidosis was a disease of the developed world. However, recent reports suggest that the disease is found in the developing countries as well. Clinical, radiological, and histopathological similarities with tuberculosis pose a great challenge in countries endemic for tuberculosis. Mantoux test, high resolution computed tomography, and transbronchial lymph node and lung biopsies are diagnostic modalities, which play an important role in the diagnosis of sarcoid. In this review, we look at the epidemiology of sarcoid in tuberculosis-endemic regions, the sarcoidosis-tuberculosis link, clinical profile, diagnostic modalities, dilemma in the diagnosis, and the treatment of this disease.

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Choroidal granuloma as an initial manifestation of systemic sarcoidosis

Cited by 16 publications

References 9 publications

Multimodal imaging of sarcoid choroidal granulomas

Multimodal imaging of sarcoid choroidal granulomas

Multi-modal imaging and anatomic classification of the white dot syndromes

Sarcoidosis in tuberculosis-endemic regions: India

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