Choroidal melanoma endoresection, dandelions and allegory-based medicine

A reappraisal of the significance of largest basal diameter of posterior uveal melanoma

“…The importance of evidence-based care is now accepted; however, we need to be conscious of how the same evidence can be interpreted in different ways. 33 As early as the mid-nineteenth century, von Graefe 34 observed that some patients with a small uveal melanoma died of metastasis, whereas others with a large tumour survived. We now know that this is because there are lethal and non-lethal subtypes of uveal melanoma.…”

Karyotype aberrations and gene mutations characteristics correlated it with UM prognosis

“…After that in 1996 Prescher G and his coworkers identified 54 UM, concluded loss of chromosome 3 in UM patients was with high risk of metastasis and approximately half of them with poor survival (the 3-year relapse-free survival rate was 50%) that compared to the disomy UM, also suggested monosomy 3 UM patients with lower mortality (lower the mortality rate of 50% after at 10 to 15 years) [8]. Meanwhile from 1998 to 2009 Damatlo B and his coworkers summarize their cases and evidences showed monosomy 3 was displayed in 50-60% of primary tumors, despite successful treatment of the primary tumor and lack of frontier knowledge that limited their ability to interpret the accuracy survival data, at least it was confirmed that monosomy 3 was correlated with bad prognosis (strongly with metastatic death, data indicating a reduction in the 5-year survival from 100% to less than 50%) [2,16].…”

“…The karyotypes of UM patients were mainly displayed monosomy 3 and gain of chromosome 8q [7] which both showed bad prognosis [13][14][15][16][17][18][19]. Researchers had further investigated uveal melanomas prognostic situations with nonrandom alterations affecting chromosomes 1, 3, 6, and 8 and clinical features.…”

Proton beam radiotherapy for uveal melanoma

“…23 Concerns about tumor dissemination seem exaggerated. 24 If the proton beam radiotherapy is likely to cause troublesome epiphora or if the toxic tumor syndrome is likely because the tumor is bulky or associated with an extensive retinal detachment, then trans-scleral tumor resection may be considered if the surgeon is experienced in the technique and if the patient is fit for hypotensive anesthesia. 15 Retinopathy is more likely to develop in diabetic patients, who may need more intensive treatment for macular edema and other complications.…”