Choroidal Melanoma: Natural History and Management Options

Bell, Darren; Wilson, Matthew W.

doi:10.1177/107327480401100503

Cited by 71 publications

(58 citation statements)

References 64 publications

(69 reference statements)

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“…Questions remain about the condition's natural history and the influence of treatment on the prognosis of CM (12) . Factors that may predict a poor prognosis include: tumour size (13)(14)(15) , old age (16) , tumour thickness (17) , and involvement of the ciliary body (18) .…”

Section: Discussionmentioning

confidence: 99%

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Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

Pasetto¹,

Freitas²,

Colossi³

et al. 2013

Rev. bras.oftalmol.

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RESUMOObjetivo: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. Métodos: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. Resultados: De um total de 18 olhos, 7 (38.9%) foram incluídos no estudo. Cinco (71,4%) pacientes foram tratados exclusivamente com termoterapia transpupilar, em 1 (14,2%) olho a crioterapia foi simultânea, 1 (14,2%) suplementou braquiterapia -placa episcleral. Três (42.8%) sofreram recorrência, 2 (28.5%) apresentaram metástases (um óbito), 2 foram enucleados. Complicações foram encontradas em 3 olhos: dobras maculares em 2, hemorragia vítrea em 1. Nos olhos enucleados, não havia extensão extraescleral, porém células interesclerais foram identificadas. Conclusão: Termoterapia transpupilar mostra um declínio em sua eficácia e conserva os riscos de metástases em períodos mais longos de acompanhamento, sendo necessária uma definição mais exata de seu papel nos melanomas de coróide.

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Section: Discussionmentioning

confidence: 99%

“…The depth to be reached can limit the method's efficiency, either in primary applications or reapplications (5)(6)(7)(8)(9)(10)(11)(12) .…”

Section: Discussionmentioning

confidence: 99%

Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

Pasetto¹,

Freitas²,

Colossi³

et al. 2013

Rev. bras.oftalmol.

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“…Choroidal melanoma1 is the most common eye cancer which originating from melanin‐containing cells and has the highest rate of metastasis among intraocular tumors 2, 3, 4, 56…”

Section: Introductionmentioning

confidence: 99%

Gamma irradiation of ocular melanoma and lymphoma cells in the presence of gold nanoparticles: in vitro study

Kanavi

Asadi

Balagholi

et al. 2018

J Applied Clin Med Phys

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The aim of this work was to determine whether conjugation of cultivated choroidal melanoma and Burkitt's lymphoma cells with gold nanoparticles (GNPs) is beneficial for these series of ocular cancer patients. GNPs are radiosensitizers and can sensitize tumors to radiotherapy.This application has been examined in several tumor types, but not in choroidal melanoma. This study shows the results of in vitro study on the choroidal melanoma and also Burkitt's lymphoma cells in the presence of GNPs during continuous gamma irradiation. Cytotoxicity of GNPs were assessed for five different concentrations then cultured melanoma and Burkitt's lymphoma cells were irradiated with a Gamma source in the presence and absence of NPs. Incubation of melanoma cells with GNP concentrations below 100 μg/ml, accompanied by gamma irradiation, increased cell death (P value = 0.016) . In the absence of irradiation, GNPs at these concentrations did not affect cultured melanoma cell metabolism. Reduced cell viability resulted from a significant increase in absorbed energy by the tumor. Moreover, GNP concentrations higher than 200 μg/ml induced cytotoxicity in melanoma cells. Cytotoxicity assay in GNPs‐loaded Burkitt's lymphoma cells showed a slight decrease in cell viability at 50 μg/ml and clear cytotoxicity at concentrations higher than 100 μg/ml (P value = 0.035). Concentration and proper injection doses of GNPs in sensitive tissues such as the human eye are important variables yet to be determined.This is the first report of choroidal melanoma dosimetry performed in the presence of GNPs and provides valuable insights into future therapeutic approaches. Further in vitro study with more different sizes and concentrations is needed to determine the optimum size and concentration before any clinical research in this regard.

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“…The procedure is now reserved for large tumours or those cases where there is no hope of regaining vision. 3 Radiation is the preferred form of treatment for most cases of UM. 4 UMs are typically treated with a calculated apex dose of 70-85 Gy.…”

Section: Introductionmentioning

confidence: 99%

“…5 Iodine-125 is the most commonly used isotope for plaque radiotherapy of choroidal melanomas, 6 although cobalt-60, ruthenium-106, iridium-192, strontium-90, and palladium-103 have also been used. 3 Modern techniques for brachytherapy involve suturing a shielded plaque containing seeds of the radioactive isotope to the sclera. This remains in place for a specified number of days to deliver the proper dose of radiation.…”

Section: Introductionmentioning

confidence: 99%

Amfenac increases the radiosensitivity of uveal melanoma cell lines

Fernandes

Marshall

Cesare

et al. 2007

Eye

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Purpose To evaluate the proliferation rates of five human uveal melanoma (UM) cell lines after treatment with amfenac, a cyclooxygenase (COX)-2 inhibitor, and subsequent radiation exposure. Methods Five human UM cell lines (92.1, SP6.5, MKT-BR, OCM-1, and UW-1) and one human fibroblast cell line (BJ) were incubated with amfenac. Treated and non-treated cell lines were then exposed to various doses of c radiation: 0, 2, 4, 6, and 8 Gy. Sulphorhodamine-B assay was used to assess proliferation rates 48 h post-radiation.

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Choroidal Melanoma: Natural History and Management Options

Cited by 71 publications

References 64 publications

Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

Gamma irradiation of ocular melanoma and lymphoma cells in the presence of gold nanoparticles: in vitro study

Amfenac increases the radiosensitivity of uveal melanoma cell lines

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