Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review

Hassan, Mohamed Sheikh; Ansari, Walid El; Alater, Ahmad; Darweesh, Adham; Abdelaal, Abdelrahman

doi:10.1016/j.ijscr.2021.106419

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…Observation may be considered for small peripheral metastatic lesions in patients with poor systemic status. Enucleation is usually considered for blind painful eyes, loss of vision, and persistent symptoms (32,37). Despite all these treatment options, there are limited data regarding treatment e cacy.…”

Section: Discussionmentioning

confidence: 99%

Uveal metastasis arising from thyroid neoplasms: a systemic review of case reports

Abdollahi

Nateghian

Sobhi

et al. 2023

Preprint

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Purpose: We systematically reviewed the case report literature to identify cases of uveal metastases (UM) originating from Thyroid Cancers (TCs) and evaluate this condition's demographic, ophthalmologic, and oncologic characteristics. Methods: Web of Science, Medline, and Scopus databases were searched for case reports or series reporting uveal metastasis originating from a thyroid neoplasm. Articles published in any language from inception through November 2022 were searched and screened independently by two reviewers. The quality of the included studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Case Reports. Results: A total of 1049 records were detected. After removing duplicates and screening articles based on title, abstract, and full text, 46 cases from 43 studies were identified. The mean (SD) age of patients at the time of UM diagnosis was 56.521 (±15.68) years (range, 20–83 years), and 16 cases (34.78%) were reported in the elderly (˃64 years). Male patients consisted 56.52% (n=26) of the cases. Sixteen cases happened in the right eye, 19 in the left eye, and 11 cases in both eyes. In total, 39 cases (84.78%) had choroidal involvement. Papillary carcinoma was the most reported type of thyroid cancer in the patients (16/46), followed by follicular (15/46) and medullary (10/46) carcinomas of the thyroid. Conclusion: Uveal metastases may appear in metastatic thyroid neoplasms. Therefore, physicians should maintain suspicion when ocular symptoms accompany a neck mass or a history of previous thyroid malignancies.

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Section: Discussionmentioning

confidence: 99%

Uveal metastasis arising from thyroid neoplasms: a systemic review of case reports

Abdollahi

Nateghian

Sobhi

et al. 2023

Preprint

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Pituitary metastases: a case series and scoping review

Yang,

Begley,

Lynch

et al. 2023

Pituitary

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Uveal metastasis arising from thyroid neoplasms: A case study synthesis

Abdollahi,

Nateghian,

Sobhi

et al. 2024

European Journal of Ophthalmology

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Purpose We systematically reviewed the case report literature to identify cases of uveal metastases originating from thyroid cancer (TC), evaluate factors and indications in uveal metastases from TC, and provide clinical insights through recent case studies. Methods Web of Science, Medline, and Scopus databases were searched for case reports or series reporting uveal metastasis from a thyroid neoplasm. Articles published in any language from inception through November 2022 were searched and screened independently by two reviewers. The quality of the included studies was assessed using the JBI Critical Appraisal Checklist for Case Reports. Results A total of 1049 records were screened, resulting in the identification of 46 cases from 43 studies. The mean (SD) age at uveal metastases diagnosis was 58.44 (±17.99) years with the median (interquartile range) of 56.5 (29.75) (range, 20–83 years), with 34.8% of cases (16/46) cases reported in elderly patients (>64 years). The sample consisted of 56.5% (26/46) male patients. Uveal metastases were observed in the right eye in 16 cases, the left eye in 19 cases, and both eyes in 11 cases. Choroidal involvement was present in 84.8% of cases (39/46) cases. Papillary carcinoma was the most common thyroid cancer type (34.8%, 16/46), followed by follicular carcinoma (32.6%, 15/46), and medullary carcinoma (21.7%, 10/46). Conclusion Uveal metastases have been observed to appear in metastatic TC, and physicians should approach ocular symptoms cautiously in cases that accompany a neck mass or a history of previous TC.

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Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review

Cited by 5 publications

References 29 publications

Uveal metastasis arising from thyroid neoplasms: a systemic review of case reports

Uveal metastasis arising from thyroid neoplasms: a systemic review of case reports

Pituitary metastases: a case series and scoping review

Uveal metastasis arising from thyroid neoplasms: A case study synthesis

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