Choroidal metastasis in disseminated lung cancer: frequency and risk factors

Kreusel, Klaus-Martin; Wiegel, Thomas; Stange, Marit; Bornfeld, Norbert; Hinkelbein, W.; Foerster, Michael

doi:10.1016/s0002-9394(02)01580-5

Cited by 118 publications

(99 citation statements)

References 7 publications

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“…6 On B-mode ultrasonography choroidal metastases reveal an irregular lumpy contour, irregular internal structure with medium to high int ernal reflectivity with no internal vascularity. 7 FFA shows diffuse or multifocal hypo fluorescence and hyper fluorescence at the retinal pigment epithelium (RPE) level overlying the lesion (due to the damaging effects of the expanding choroidal tumour on the overlying retinal pigment epithelium), pinpoint hyperfluorescent foci at the RPE level, over the surface of the tumour by the late phase (due to microcystic RPE degeneration). 8 If there is evidence of systemic metastatic disease, then treatment of the non-ocular and ocular metastatic tumours consists of chemotherapy, hormone therapy, immunotherapy, multiple-site radiotherapy, or observation.…”

Section: Discussionmentioning

confidence: 99%

Choroidal metastasis as initial presentation of squamous cell carcinoma lung in a patient who had undergone treatment for carcinoma hypopharynx

Jilla¹,

Prathipati²,

B³

et al. 2016

JCSR

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Choroidal metastasis is the most common intraocular malignancy followed by ocular melanoma. This presentation is reported commonly in breast and lung malignancies with multifocal involvement of one eye, or involvement of both eyes. In lung cancer, it is seen in 50-60 year old males with histopathological diagnosis of adenocarcinoma. Here we report the rare occurrence of squamous cell carcinoma lung in 35 year-old female with choroidal metastasis as initial presentation in a patient who had undergone treatment for carcinoma hypopharynx as metachronous second primary. Key word: Secondary choroidal neoplasm, Squamous cell carcinoma, Lung, Ophthalmoscopy

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Section: Discussionmentioning

confidence: 99%

Choroidal metastasis as initial presentation of squamous cell carcinoma lung in a patient who had undergone treatment for carcinoma hypopharynx

Jilla¹,

Prathipati²,

B³

et al. 2016

JCSR

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“…Upon diagnosis of uveal metastasis, more than half of the patients had associated systemic metastasis with the lungs being the most frequent site with concomitant involvement, followed by the bone, liver and central nervous system (20,22 only significant risk factors for the development of choroidal disease in patients with breast carcinomas with an incidence of 11% in the presence of these factors as compared to 5% in their absence (5). Kreusel et al found that metastasis in more than one organ is a significant risk factor for choroidal metastasis in patients with lung cancer (7). The prognosis following diagnosis of uveal metastasis is poor, with a median survival of 6-9 months (7,(22)(23)(24).…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Kreusel et al found that metastasis in more than one organ is a significant risk factor for choroidal metastasis in patients with lung cancer (7). The prognosis following diagnosis of uveal metastasis is poor, with a median survival of 6-9 months (7,(22)(23)(24).…”

Section: Patient Characteristicsmentioning

confidence: 99%

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Uveal metastatic disease: Current and new treatment options (Review)

Giuliari¹,

Sadaka²

2011

Oncol Rep

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Abstract. Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ocular metastasis are breast cancer in women and lung cancer in men. In most cases, these lesions tend to be asymptomatic and are not evaluated by an ophthalmologist. The diagnosis is generally made by the history of present or prior malignancies and an ophthalmological examination with slit-lamp biomicroscopy and indirect ophthalmoscopy. As with other malignancies, management may vary with each patient. Small tumors, that do not compromise the vision and that have responded previously to systemic treatment, may be closely observed. For larger lesions and for symptomatic ones, external beam radiation offers an excellent alternative to save the eye and stabilize vision. Bevacizumab (Avastin), a potent monoclonal antibody that has also been employed for the treatment of ocular vaso-proliferative diseases, has been used in the treatment of choroidal metastasis and has shown promising results.

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“…The lung cancer is the first cause of choroidal metastasis in men, as the breast cancer is in women. Estimates of the incidence of intraocular metastases in patients dying from disseminated cancer range from 22,000 to 66,000 affected individuals per year in the United States (3) .…”

Section: Introductionmentioning

confidence: 99%