Choroidal Thickness in Best Vitelliform Macular Dystrophy

Abstract

Choroidal thickness varies according to the stage of VMD, being higher in the vitelliform stage and thinner in the atrophic/cicatricial stage. Long-term studies are warranted to provide a more precise evaluation of the morphofunctional alterations in the different stages of VMD.

Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy

“…2,24 Typically, VMD is characterized by high phenotypic heterogeneity and variable clinical manifestations. [1][2][3][4][5][6][7][8][9][10][11] MNV has been previously described as a possible complication, especially in the early stages of VMD. 1,2,[10][11][12][13]25,26 In most cases, exudative manifestations due to MNV activity have been treated with anti-VEGF intravitreal injections, with positive outcomes.…”

“…B est vitelliform macular dystrophy (VMD) can show mutable phenotypic manifestations over its natural evolution from the initial vitelliform stage toward a gradual reabsorption of vitelliform material and up to atrophic changes. [1][2][3][4][5][6][7][8][9][10] Macular neovascularization (MNV) can complicate the course of VMD and may contribute toward a further deterioration in visual acuity. 1,2,11,12 The diagnosis of MNV complicating VMD is often not straightforward.…”

Choroidal structural analysis and vascularity index in retinal dystrophies

“…In Best disease, choroidal thickness varied depending on the disease stage, being higher in the vitelliform/pseudohypopyon stage, thinner in the atrophic stage and similar to normal controls in the previtelliform and vitelliruptive stage (Battaglia Parodi et al. ). Corresponding to the changes in choroid thickness, CVI was reduced in all subgroups of the retinal dystrophies in our study.…”

Swept-source optical coherence tomography study of choroidal morphology in Stargardt disease

“…We could not detect any correlation between the anatomic variations and the extent of flecks with choroidal layer thickness. In a study by Battaglia Parodi et al .,[ 20 ] the CT varied according to the stage of the Best vitelliform macular dystrophy. In their series of eyes, the choroid was thicker in the stage with vitelliform deposition and it was thinner in the cicatricial or atrophic stage.…”