Choroidal Thickness in Infants With Retinopathy of Prematurity

Erol, Muhammet Kazım; Çoban, Deniz; Özdemir, Özdemir; Doğan, Berna; Tunay, Zühal Özen; Bulut, Mehmet

doi:10.1097/iae.0000000000000866

Cited by 50 publications

(50 citation statements)

References 26 publications

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“…This observation was corroborated by several independent clinical investigations, 10e12,46 wherein choroidal thinning was reported in children and adolescents Photoreceptor functional degeneration in oxygeninduced retinopathy (OIR) rats. AeQ: Scotopic electroretinogram analysis of animals at different ages (P30, P60, P150, and P210) and exposed to cycling oxygen (OIR) or maintained in normoxia (Nor) and treated or not with IL-1ra (from P1 until P14).…”

supporting

confidence: 73%

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Zhou

Rivera

Bhosle

et al. 2016

The American Journal of Pathology

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Retinopathy of prematurity (ROP), the most common cause of blindness in premature infants, has long been associated with inner retinal alterations. However, recent studies reveal outer retinal dysfunctions in patients formerly afflicted with ROP. We have recently demonstrated that choroidal involution occurs early in retinopathy. Herein, we investigated the mechanisms underlying the choroidal involution and its long-term impact on retinal function. An oxygen-induced retinopathy (OIR) model was used. In vitro and ex vivo assays were applied to evaluate cytotoxic effects of IL-1β on choroidal endothelium. Electroretinogram was used to evaluate visual function. We found that proinflammatory IL-1β was markedly increased in retinal pigment epithelium (RPE)/choroid and positively correlated with choroidal degeneration in the early stages of retinopathy. IL-1β was found to be cytotoxic to choroid in vitro, ex vivo, and in vivo. Long-term effects on choroidal involution included a hypoxic outer neuroretina, associated with a progressive loss of RPE and photoreceptors, and visual deterioration. Early inhibition of IL-1β receptor preserved choroid, decreased subretinal hypoxia, and prevented RPE/photoreceptor death, resulting in life-long improved visual function in IL-1 receptor antagonist-treated OIR animals. Together, these findings suggest a critical role for IL-1β-induced choroidal degeneration in outer retinal dysfunction. Neonatal therapy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesting IL-1β as a potential therapeutic target in ROP.

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supporting

confidence: 73%

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Zhou

Rivera

Bhosle

et al. 2016

The American Journal of Pathology

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“…In subjects with ROP, both at preterm ages (Erol et al, 2016) and in adolescence (Anderson et al, 2014), the choroid is too thin. These human data do not give temporal priority to the choroidal abnormality over the onset of ROP.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

The neural retina in retinopathy of prematurity

Hansen

Moskowitz

Akula

et al. 2017

Progress in Retinal and Eye Research

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Retinopathy of prematurity (ROP) is a neurovascular disease that affects prematurely born infants and is known to have significant long term effects on vision. We conducted the studies described herein not only to learn more about vision but also about the pathogenesis of ROP. The coincidence of ROP onset and rapid developmental elongation of the rod photoreceptor outer segments motivated us to consider the role of the rods in this disease. We used noninvasive electroretinographic (ERG), psychophysical, and retinal imaging procedures to study the function and structure of the neurosensory retina. Rod photoreceptor and post-receptor responses are significantly altered years after the preterm days during which ROP is an active disease. The alterations include persistent rod dysfunction, and evidence of compensatory remodeling of the post-receptor retina is found in ERG responses to full-field stimuli and in psychophysical thresholds that probe small retinal regions. In the central retina, both Mild and Severe ROP delay maturation of parafoveal scotopic thresholds and are associated with attenuation of cone mediated multifocal ERG responses, significant thickening of post-receptor retinal laminae, and dysmorphic cone photoreceptors. These results have implications for vision and control of eye growth and refractive development and suggest future research directions. These results also lead to a proposal for noninvasive management using light that may add to the currently invasive therapeutic armamentarium against ROP.

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“…Moreno et al [35] demonstrated the feasibility of using SD-OCT to examine the choroid in premature infants, and visualized the choroidoscleral junction in 78%. Similarly, Erol et al [8] were able to measure subfoveal CT in 80% of the premature infants. The SS-OCT single scans in our study visualized the choroidoscleral junction at all eccentricities of the scan of every child and young adult, in agreement with the results reported by Copete et al [14] for healthy subjects.…”

Section: Discussionmentioning

confidence: 98%

“…Several studies already measured CT in premature children using SD-OCT [7, 8, 10]. However, to our knowledge, this is the first study to measure CT in young preterm infants using the superior SS-OCT technique.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity

Bowl¹,

Bowl²,

Schweinfurth³

et al. 2018

Ophthalmic Res

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Aim: Comparison of choroidal thickness (CT) and foveal morphology as seen with swept-source optical coherence tomography (SS-OCT) in children with a history of treated or spontaneously regressed retinopathy of prematurity (tROP or srROP) to assess the impact on best-corrected visual acuity (BCVA). Methods: CT was measured by SS-OCT (DRI-OCT Triton; Topcon, USA) single scans of a 6-mm diameter around the fovea in 17 children with tROP or srROP (4–7 years of age) and compared to 25 controls (age-matched children and adults). The disproportion of the outer nuclear layer and inner retinal layers at the fovea (i.e., the ONL+/IRL ratio) as a measure of macular developmental arrest (MDA) was manually analyzed. BCVA was tested with ETDRS letter charts and correlated with the morphology. Results: CT was significantly thinner in children with tROP and srROP compared to term-born healthy children (nKids) at all measurement marks (p < 0.001), and mostly affected in the subfoveal area. tROP showed the lowest CT. CT allowed no direct conclusion about ONL+/IRL, but correlated positively with BCVA. Conclusions: Reduced CT in children with a history of ROP is linked to ROP severity. These findings overlap with the degree of MDA. CT appears to be involved in ROP, but MDA showed a higher impact on the BCVA of the examined cohort.

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Choroidal Thickness in Infants With Retinopathy of Prematurity

Cited by 50 publications

References 26 publications

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

The neural retina in retinopathy of prematurity

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity

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