Choroidal Thickness Measurement in Highly Myopic Eyes Using SD-OCT

Matri, L. El; Bouladi, M; Chebil, Ahmed; Kort, Fedra; Bouraoui, R.; Largueche, Leila; Mghaieth, F.

doi:10.3928/15428877-20121001-02

Cited by 28 publications

(11 citation statements)

References 19 publications

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“…As an example, in Vogt-Koyanagi-Harada disease choroidal thickness is reduced after succesful steroid treatment; therefore, can be an important indicator for the assessment of corticosteroid treatment efficacy [16]. Recent studies also showed a decrease in choroidal thickness in highly myopic eyes [27,28] which is supposed to be a significant risk for the developement of choroidal neovascularisation. Other recently published data showed that macular choroidal thickness is not influenced by intraocular pressure [29].…”

Section: Discussionmentioning

confidence: 99%

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

et al. 2014

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BackgroundAcute severe postoperative endophthalmitis may lead to severe vision loss. The aim of this study was the analysis of macular microstructure imaged by spectral domain optical coherence tomography in patients after pars plana vitrectomy due to postcataract endophthalmitis.MethodsA cross sectional study was carried out in 17 patients who had cataract surgery in both eyes and underwent unilateral pars plana vitrectomy due to postcataract endophthalmitis. Postoperative best corrected visual acuity was determined in both eyes. Evaluation of macular thickness, macular volume, peripapillary retinal nerve fiber layer thickness and choroidal thickness using enhanced depth imaging technique was performed by spectral domain optical coherence tomography. The measurements obtained in the operated eye were compared to the fellow eye by Wilcoxon matched pair test. Correlation test was performed by Spearman rank order.ResultsA mean postoperative best corrected visual acuity of 63 ± 30 ETDRS letters versus 75 ± 21 letters was achieved in the study and fellow eyes, respectively, after a mean of 5.3 ± 4.5 months (p = 0.1). The mean macular thickness was 320.6 ± 28.8 μm SD in the study eyes compared to 318.4 ± 18.8 μm in the fellow eyes (p = 0.767). No differences were noted in macular volume (p = 0.97) and in peripapillary retinal nerve fiber layer thickness (p = 0.31). Choroidal thickness was significantly lower in the study eyes compared to the fellow eyes (p = 0.018). Epiretinal membrane was found in 7 eyes after endophthalmitis, while in the fellow eyes only in 3 cases (p = 0.13, Fisher’s exact test).ConclusionChoroidal thickness decreased significantly after endophthalmitis, but there was no functional correlation with the changes in choroidal microstructure. The development of epiretinal membranes may be associated with either vitrectomy or endophthalmitis in the history. Absence of other significant structural and morphological findings shows that successful treatment may guarantee good clinical results even in long term after this severe postoperative complication.

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Section: Discussionmentioning

confidence: 99%

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

et al. 2014

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“…For each location, the average of the two readers’ measurements was used or the consensus value, if necessary. Consensus grading occurred if the two readers’ choroidal thickness differed by either 15% 23-24 or 30 μm. This method of manual choroidal thickness measurement using digital calipers has been shown to be highly repeatable.…”

Section: Methodsmentioning

confidence: 99%

Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort

Dirkes¹,

Zangwill²,

Gwiazda

et al. 2015

American Journal of Ophthalmology

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Purpose To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. Design Cross-sectional, multi-center, study Methods In addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid (RTVue) in both eyes at their last visit (14 years after baseline). Using digital calipers, two independent readers measured choroidal thickness in the right eye (left eye if poor quality; n=37) at seven locations: fovea and 750, 1500, 2250μm nasal (N) and temporal (T) to the fovea. Results Choroidal thickness measurements were available from 294/346 (85%) of imaged participants (mean age: 24.3±1.4 years; 44.9% male) with mean myopia of -5.3±2.0D and mean AL of 25.5±1.0mm. Overall, choroidal thickness varied by location (p<0.0001) and was thickest at the fovea (273.8±70.9 μm) and thinnest nasally (N2250,191.5±69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (p≤0.001) and presence of peri-papillary crescent at all locations except T1500 and T2250 (p≤0.0001). Choroidal thickness varied by ethnicity at N2250 (p<0.0001), with Asians having the thinnest and African Americans the thickest choroids. Conclusion Choroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically.

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“…6 A significant thinning in CT related with myopia was observed and CT in myopia had negative correlation with refractive power, axial length, and age, which was mentioned in previous studies (Table 3). 5,6,16,18,19 Excimer laser refractive surgery is a common option for correcting myopia. Our study, first reported that the choroid becomes thicker following myopic refractive surgery.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 In profoundly affected myopic eyes, the choroid is thinner than in normal eyes, and it undergoes further thinning with age and increasing myopia. 5,6 A thinner choroid could be instrumental in the onset and progression of severe myopia-related diseases. 7 Increasing numbers of ophthalmic scholars and clinicians are focusing on choroidopathy induced by myopia.…”

Section: Introductionmentioning

confidence: 99%

Change in choroidal thickness and the relationship with accommodation following myopic excimer laser surgery

Cheng

Yuan

et al. 2016

Eye

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Purpose To investigate early changes in choroidal thickness (CT) and the relationship with accommodation after myopic excimer laser surgery. Methods We enrolled the right eye of 70 patients with myopia and without other ophthalmic or systemic diseases who were suitable for myopic excimer laser surgery. The CT was measured at the fovea and at distances of 0.5 and 2.5 mm for the following: nasal; temporal; superior; and inferior to the fovea preoperatively and at 1 month postoperatively. Other data collected included demographic information (age, sex, and refractive error), the amplitude of accommodation (AA), intraocular pressure, axial length, corneal thickness, and surgical parameters. The data were analyzed with a paired Student's t-test, stepwise linear regression, and correlation analysis. Results The CT was significantly thicker postoperatively compared with the preoperative CT. The AA significantly decreased postoperatively. The change in the AA was the most significant factor associated with the change in the CT at the fovea. Except for 2.5 mm inferior to the fovea, the increase in the CT at other locations was positively correlated with the decrease in the AA. Conclusions The CT increased following myopic excimer laser surgery and the change was most obvious when accompanied by a decrease in the AA early after the surgery.

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Choroidal Thickness Measurement in Highly Myopic Eyes Using SD-OCT

Abstract: In highly myopic eyes, the choroid is thin and undergoes further attenuation with age and increasing myopia. In addition, these findings suggest that the choroid may play a role in the pathogenesis of CNV.

Cited by 28 publications

References 19 publications

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort

Change in choroidal thickness and the relationship with accommodation following myopic excimer laser surgery

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