Choroidal vascularity index and choriocapillary changes in retinal vein occlusions

Arıbaş, Yavuz Kemal; Hondur, Ahmet; Tezel, Tongalp H.

doi:10.1007/s00417-020-04886-3

Cited by 38 publications

(51 citation statements)

References 30 publications

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“…A possible mechanism of the decreased CVI in the eyes with BRVO and ME eyes could be extracellular fluid shift from retina to choroid. Aribas et al [ 18 ] considered a pressure effect of choroidal congestion as the main cause of decreased CVI in BRVO. They demonstrated that the rush of extracellular fluid toward choroids through outer retinal barrier was caused by the blockage of retinal venous outflow and facilitated by ischemia-induced Aquaporin 9.…”

Section: Discussionmentioning

confidence: 99%

Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

2021

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Purpose To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. Methods 35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT). Results The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05). Conclusions The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.

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Section: Discussionmentioning

confidence: 99%

Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

2021

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“…Even if CC was too thin layer to have a signi cant effect on CVI by itself, CC regression would increase the resistance of the overall choroidal vessels, resulting in decreased choroidal blood ow. Aribas et al 21 considered a pressure effect of choroidal congestion as the main cause of decreased CVI and CC ow density in BRVO. However, the supposition differs from ours in that the gradual effect of excessive VEGF on the choroid vascular structure was totally excluded in the report.…”

Section: Discussionmentioning

confidence: 99%

Role of the Choroidal Vascularity Index in Branch Retinal Vein Occlusion with Macular Edema

Hwang

Kim

Park

2021

Preprint

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The purpose of this study was to assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. 35 patients (70 eyes) with BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters and logMAR visual acuity (VA) two years post disease onset. The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2=0.433, p<0.001). No remarkable R2 values were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2=0.189, 0.155, respectively, p<0.05). Reduced CVI in BRVO and ME suggests that retinal ischemia and choroidal vascular changes might be closely related. The fellow eye CVI could be a useful supplementary prognostic biomarker.

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“…However, most studies have reported that the CVI decreases with increasing axial length. (24,27,28) The ratio of stroma to vessels has been suggested as a key component influencing the choriocapillaris flow and is also involved in the pathogenesis of various chorioretinal diseases (11,(33)(34)(35)(36)(37). However, few studies have focused on the choroidal stroma and analyzed their characteristics in en face OCT images of normal subjects.…”

Section: Introductionmentioning

confidence: 99%

Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects

Kim¹,

Oh²

2022

Quant Imaging Med Surg

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Background: Advancement of optical coherence tomography (OCT) technology allows for better in vivo visualization of the choroidal architecture, which comprises vessels and stroma. However, most OCT studies using image binarization methods have focused only on choroidal vessels represented by dark pixels. This study aimed to compare the distribution of choroidal hyperreflective spots on swept-source OCT (SS-OCT) images between both eyes of normal subjects.Methods: In this observational comparative study, we included SS-OCT images of healthy subjects, which were prospectively obtained to compare images among the devices. SS-OCT images acquired using PLEX Elite 9000 and DRI-OCT Triton were analyzed. En-face OCT images were obtained at five different depth positions of the inner choroid at the macula. The mean reflectivity of the choroidal slabs, the number, total area, and circularity of hyperreflective spots were quantitatively compared between the devices and between both eyes of the same subjects.Results: In 30 eyes of 15 healthy subjects, the mean reflectivity of the choroidal slabs varied with the scan depth on both devices (P<0.001 and P<0.001). Hyperreflective spots were similarly distributed in the images from both devices, but at different depths. The number and area of hyperreflective spots in the second and third layers of the DRI-OCT Triton were positively correlated with those in the fourth and fifth layers of the PLEX Elite 9000, respectively (all P<0.05). The intraclass correlation coefficients (ICC) for the area of hyperreflective spots were excellent for the third slab of the DRI-OCT and the fifth slab of the PLEX Elite (ICC =0.798; 95% CI, −0.576-0.904). The number and area of hyperreflective spots were correlated between both eyes in the third, fourth and fifth layers on DRI-OCT Triton (all P<0.05) and in the first, second, and fifth layers on PLEX Elite 9000 (all P<0.05).Conclusions: Hyperreflective spots in en-face images from two different SS-OCT devices were similarly observed between both eyes of the same person. The distributions of spots between the two eyes of the same person were correlated. These findings suggest that the distribution of hyperreflective spots on the choroid reflects the choroidal characteristics of the subject.

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Choroidal vascularity index and choriocapillary changes in retinal vein occlusions

Cited by 38 publications

References 30 publications

Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

Role of the Choroidal Vascularity Index in Branch Retinal Vein Occlusion with Macular Edema

Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects

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