Choroidal vascularity index in adults with different refractive status

Alis, Meryem Guler; Alış, Abdülkadir

doi:10.1016/j.pdpdt.2021.102533

Cited by 21 publications

(20 citation statements)

References 36 publications

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“…For example, several studies have suggested that the choroid is thinner in myopic than in emmetropic eyes and that its thickness is negatively correlated with axial length. 9,[11][12][13][14] Similar findings have also been found in hyperopic eyes. 15 Choroidal vascular perfusion also varies with choroidal thickness (CT) in both myopic and hyperopic eyes, with greater perfusion in hyperopic eyes.…”

supporting

confidence: 84%

Assessment of the effects of myopic and hyperopic anisometropia on choroidal vascular structure in children using SS‐OCTA

Cao,

Gu,

Zhang

et al. 2024

Ophthalmic Physiologic Optic

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ObjectiveTo compare large‐ and medium‐sized choroidal vascularity and the choriocapillaris (CC) flow area in children with different refractive errors using swept‐source optical coherence tomography angiography (SS‐OCTA).MethodsForty‐two anisometropic children were enrolled and divided into hyperopic anisometropia (HA) and myopic anisometropia (MA) groups. SS‐OCTA was performed to analyse choroidal vascularity. Mean choroidal thickness (CT), choroidal vascularity volume (CVV), choroidal vascularity index (CVI) and CC flow area were compared between the two eyes. The inter‐ocular differences between the two groups were also determined.ResultsMean CT and CVV were highest in eyes with shorter axial lengths in both refractive groups, and the difference between the two eyes was positively correlated with the difference in axial length at the foveal region. Significant differences in the CVI in the MA group were only found in the parafoveal region. Inter‐ocular differences in the CC were significantly reduced in eyes with longer axial lengths in the foveal and parafoveal regions of the HA and MA groups, respectively. Comparing inter‐ocular differences, CC was significantly greater in the parafoveal region of the MA group than the HA group.ConclusionsAll layers of choroidal vasculature were thinner in eyes with longer axial lengths in all groups. The inter‐ocular CC difference was greater in the MA than in the HA group, with similar differences in axial length. This suggests that both medium‐to‐large choroidal vascular and choroidal capillaries may play a role in myopia development.

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supporting

confidence: 84%

Assessment of the effects of myopic and hyperopic anisometropia on choroidal vascular structure in children using SS‐OCTA

Cao,

Gu,

Zhang

et al. 2024

Ophthalmic Physiologic Optic

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“…[46][47][48][49][50][51][52][53] The reason for this discrepancy still needs further investigation, but it should be noted that longitudinal changes in choroidal parameters cannot be ascertained owing to the cross-sectional nature of these studies. [46][47][48][49][50][51][52][53] The primary study, which this secondary analysis draws from, has also reported choroidal thinning accompanying myopia progression in children. 21 However, detailed choroidal structural alterations in the observed choroidal thinning 21 is unknown in part due to the difficulties in their measurements.…”

Section: Discussionmentioning

confidence: 95%

“…Some cross-sectional studies investigated the choroidal structural changes in myopic eyes and they found that smaller LA, SA, and TCA were associated with a higher degree of myopia, whereas the change of CVI was not conclusive (Supplementary Digital Content Table 2, http://links.lww.com/APJO/A255). 46–53 The reason for this discrepancy still needs further investigation, but it should be noted that longitudinal changes in choroidal parameters cannot be ascertained owing to the cross-sectional nature of these studies 46–53 . The primary study, which this secondary analysis draws from, has also reported choroidal thinning accompanying myopia progression in children 21 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Changes in Choroidal Structure Following Repeated Low-Level Red-Light Therapy for Myopia Control: Secondary Analysis of a Randomized Controlled Trial

Xuan

Zhu

Jiang

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: Repeated low-level red-light (RLRL) therapy has been confirmed as a novel intervention for myopia control in children. This study aims to investigate longitudinal changes in choroidal structure in myopic children following 12-month RLRL treatment. Materials and Methods: The current study is a secondary analysis from a multicenter, randomized controlled trial (NCT04073238). Choroidal parameters were derived from baseline and follow-up swept-source optical coherence tomography scans taken at 1, 3, 6, and 12 months. These parameters included the luminal area (LA), stromal area (SA), total choroidal area (TCA; a combination of LA and SA), and choroidal vascularity index (CVI; ratio of LA to TCA), which were automatically measured by a validated custom choroidal structure assessment tool. Results: A total of 143 children (88.3% of all participants) with sufficient image quality were included in the analysis (n=67 in the RLRL and n=76 in the control groups). At the 12-month visit, all choroidal parameters increased in the RLRL group, with changes from baseline of 11.70×103 μm2 (95% CI: 4.14–19.26×103 μm2), 3.92×103 μm2 (95% CI: 0.56–7.27×103 μm2), 15.61×103 μm2 (95% CI: 5.02–26.20×103 μm2), and 0.21% (95% CI: –0.09% to 0.51%) for LA, SA, TCA, and CVI, respectively, whereas these parameters reduced in the control group. Conclusions: Following RLRL therapy, the choroidal thickening was found to be accompanied by increases in both the vessel LA and SA, with the increase in LA being greater than that of SA. In the control group, with myopia progression, both the LA and SA decreased over time.

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“…A similar study in terms of study group age was conducted by Alis et al . [ 21 ] They investigated CVI in different refractive statuses. They found that hyperopic patients had lower CVI than emmetropic and myopic patients.…”

Section: Discussionmentioning

confidence: 99%

How does anisometropia affect the choroidal vascularity index?

Cevher

Üçer²,

Şahı̇n³

2022

Indian Journal of Ophthalmology

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Purpose: To investigate the choroidal vascularity index (CVI) and morphological features of the choroid in anisometropic amblyopia. Methods: In this prospective cross-sectional study, 39 patients with unilateral anisometropic amblyopic patients and 33 eyes of 33 healthy control participants were involved. These participants were examined in terms of axial length (AL), spherical equivalent (SE), central macular thickness (CMT), choroidal thickness (CT), total choroidal area (TCA), luminal area (LA), stromal area (SA), LA/SA ratio, and CVI. All parameters were compared between amblyopic eyes, healthy fellow eyes, and healthy control eyes. The Shapiro–Wilk tests, Chi-square test, the paired t -test, Wilcoxon signed-rank test, Mann–Whitney U test, Kruskal–Wallis test, and Pearson/Spearman correlation tests were used. Results: In the hyperopic patients; SE, subfoveal CT, nasal CT, temporal CT, TCA, LA, SA, and CMT were greater in amblyopic eyes than in healthy fellow eyes and control eyes ( P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively), and CVI, LA/SA ratio, and AL were smaller in amblyopic eyes than in healthy fellow eyes and control eyes ([ P < 0.001, P = 0.006], P < 0.001, and P < 0.001, respectively). In the myopic patients, subfoveal CT, nasal CT, temporal CT, TCA, LA, SA values were statistically smaller in amblyopic eyes than in healthy eyes and control eyes ([ P < 0.001, P = 0.002), [ P = 0.004, P = 0.012], [ P = 0.012, P = 0.032], [ P < 0.001, P = 0.013], [ P < 0.001, P = 0.024], and [ P < 0.001, P = 0.047], respectively). The differences in the AL and choroidal parameters were due to myopia and hyperopia. Conclusion: The choroidal structural parameters of the amblyopic eyes were different from that of the healthy eyes.

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Choroidal vascularity index in adults with different refractive status

Cited by 21 publications

References 36 publications

Assessment of the effects of myopic and hyperopic anisometropia on choroidal vascular structure in children using SS‐OCTA

Assessment of the effects of myopic and hyperopic anisometropia on choroidal vascular structure in children using SS‐OCTA

Longitudinal Changes in Choroidal Structure Following Repeated Low-Level Red-Light Therapy for Myopia Control: Secondary Analysis of a Randomized Controlled Trial

How does anisometropia affect the choroidal vascularity index?

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