Choroidal vascularity index in pseudoexfoliative glaucoma

Karslıoğlu, Melisa Zişan; Kesim, Cem; Yucel, Ozum; Taş, Ayşe Yıldız; Torun, Safak; Altan, Çiğdem; Şahin, Afsun

doi:10.1007/s10792-021-01990-z

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…In addition, 30 min after exercise, higher values of TCA, LA, and CVI were found in glaucoma compared to those immediately after exercise, indicating restoration of choroidal vascular perfusion. Recently, a few studies have investigated the choroidal angioarchitecture in patients with glaucoma using CVI or CT ( Park et al, 2019 ; Park et al, 2018 ; Suh et al, 2019 ; Karslioglu et al, 2021 ). However, no study has focused on the fluctuation of the choroidal vascular structure before and after 20-min running at a regular speed using the quantitative imaging biomarker, such as CVI.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Vascularity Index Changes After Exercise in Patients With Glaucoma

et al. 2022

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Purpose: To investigate the changes in choroidal vascular structures after exercise in patients with glaucoma using an image binarisation algorithm with enhanced-depth imaging optical coherence tomography.Methods: Thirty-four eyes of 19 patients with primary open-angle glaucoma and 40 eyes of 20 normal subjects were included in the glaucoma and control groups, respectively. All subjects were evaluated before, immediately after, and 30 min after 20-min running at moderate speed. The subfoveal choroidal area was segmented into the luminal area (LA) and stromal area (SA), and the choroidal vascularity index (CVI) was measured by calculating the ratio of LA to the total choroidal area (TCA). The mean intraocular pressure (IOP), subfoveal choroidal thickness, CVI, SA, CA, and TCA were compared within and between both groups. The correlation between CVI, IOP, and other vascular indexes was investigated.Results: In the glaucoma group, a significantly lower CVI was found immediately after exercise and recovered 30 min after exercise. Higher TCA and LA levels were demonstrated 30 min after exercise compared to immediately after exercise. In both groups, IOP decreased immediately after exercise but was restored after a 30-min rest. In the glaucoma group, there was a higher correlation between CVI and other choroidal vascular parameters than in the control group. There was no difference in IOP or choroidal parameters between the groups at different time points.Conclusion: In patients with glaucoma, CVI decreased significantly immediately after exercise, indicating that the choroidal layer is affected by exercise and an unhealthy vascular regulatory mechanism.

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Section: Discussionmentioning

confidence: 99%

Choroidal Vascularity Index Changes After Exercise in Patients With Glaucoma

et al. 2022

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“…18,19 Macular and peripapillary EDI-SD-OCT scans were binarized with the ImageJ 1.51s (National Institutes of Health, Bethesda, MD) for CVI assessment, using a semiautomated technique previously reported. [20][21][22] The polygon tool was utilized to evaluate the region of interest (ROI) for the whole length of the OCT scan once the EDI-OCT image was loaded in ImageJ. The upper ROI boundary was created along the basal border retinal pigment epithelium, whereas the lower ROI boundary was established along the choroidal scleral border to define the TCA (1500 μm width on 2 sides from the fovea).…”

Section: Methodsmentioning

confidence: 99%

“…Macular and peripapillary EDI-SD-OCT scans were binarized with the ImageJ 1.51s (National Institutes of Health, Bethesda, MD) for CVI assessment, using a semi-automated technique previously reported 20–22. The polygon tool was utilized to evaluate the region of interest (ROI) for the whole length of the OCT scan once the EDI-OCT image was loaded in ImageJ.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Latanoprost on Choroidal Vascularity Index in Glaucoma and Ocular Hypertension

Çakır

Pehlivanoğlu

Yalçınkaya

et al. 2022

Journal of Glaucoma

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The choroidal vascularity index (CVI) is a new marker for the choroid. The decrease in CVI following latanoprost use can provide a better understanding of the pathogenesis of the posterior segment side effects of latanoprost such as cystoid macular edema and central serous choroidopathy.Purpose: The purpose of this paper is to evaluate the changes in the CVI, total choroidal area (TCA), stromal area (SA), luminal area (LA), and choroidal thickness (CT) following latanoprost therapy in patients with primary open angle glaucoma and ocular hypertension.Materials and Methods: Patients with newly diagnosed primary open angle glaucoma or ocular hypertension who had never received antiglaucoma therapy were included. Each patient received latanoprost 0.005% once daily. Enhanced depth imaging mode of spectral-domain optical coherence tomography scans was taken before the start of latanoprost therapy and in the first and third months. Subfoveal CT, CVI, TCA, LA, and SA for the submacular area, and 4 quadrants of the peripapillary area were calculated from the scans.Results: A total of 36 eyes of 18 patients were analyzed. Subfoveal CT increased significantly (P = 0.007). Mean TCA (P = 0.008) and SA (P < 0.001) in the first and third months were higher than baseline in the submacular regions. Mean CVI was lower in the first and third months (P < 0.001). There was an increase in the mean TCA and SA in the peripapillary temporal (P = 0.001 and 0.028) and inferior (P = 0.002 and <0.001) quadrants and a decrease in mean CVI in the temporal (P = 0.027) and inferior (P = 0.003) peripapillary quadrants. A negative correlation was found between the rate of decrease in intraocular pressure and the macular region CVI.Conclusions: Following latanoprost use for several months, the CVI was significantly decreased in newly treated patients with glaucoma or ocular hypertension, among other changes to the choroid. These findings may contribute to a better understanding of the effects of prostaglandins on the posterior segment of the eye.

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“…Dysfunction of the endothelium, aggregation of platelets, and disruption of clotting factors are examples of potential modes of action. Additionally, elastolysis, oxidative stress, and changes to the extracellular matrix of various tissues (mostly arteries) may be involved [ 33 ].…”

Section: Reviewmentioning

confidence: 99%

Cardiovascular Manifestations of Pseudoexfoliation Syndrome: A Narrative Review

Bora,

Prasad,

Mathurkar

et al. 2024

Cureus

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Pseudoexfoliation syndrome (PEX) is a long-term, age-related extracellular matrix condition that causes aberrant fibrillary pseudoexfoliative material (PXM) to accumulate in various body tissues. The anterior portion of the eye is where this disorder most frequently presents. It affects the entire body. Most frequently, it is seen in older people, usually those over 50. Fibrillar deposits are a symptom of the pseudoexfoliation syndrome and are found in the anterior part of the eye. Deposition of fibrillary white flaky material is seen. The lens capsule, cornea, ciliary epithelium, lens epithelium, iris pigment epithelium, zonules, orbital soft tissues, trabecular meshwork, iris blood vessels, and iris stroma have all been reported to show such depositions. The skin, heart, lungs, liver, kidneys, and other organs have also been reported to contain these deposits. Asymmetrical and bilateral illnesses are both possible. Myocardial infarction, cerebrovascular accidents, and systemic hypertension have all been linked to it. The pseudoexfoliative condition was first reported with the characteristic findings of white or grey flakes on the anterior lens capsule, the prevalence of glaucoma rising with age, and its presence in about 50% of eyes. A few decades later, the term pseudoexfoliation was given to differentiate it from the true exfoliation syndrome. True exfoliation syndrome is characterized by lamellar delamination of the lens capsule and is caused by exposure to infrared radiation. It is commonly seen in glassblowers. Age is a risk factor for PEX once a person reaches 70. Symptoms of PEX include elevated intraocular pressure, peripapillary transillumination deficiencies, potential glaucomatous optic nerve damage, poor dilatation, Sampaolesi line, and fibrillar white flaky deposits along the pupillary border. Meanwhile, fibrillar white flaky deposits on the anterior lens capsule (Hoarfrost Ring) and pigment dispersion syndrome are not pathognomonic.

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Choroidal vascularity index in pseudoexfoliative glaucoma

Cited by 11 publications

References 46 publications

Choroidal Vascularity Index Changes After Exercise in Patients With Glaucoma

Choroidal Vascularity Index Changes After Exercise in Patients With Glaucoma

The Effect of Latanoprost on Choroidal Vascularity Index in Glaucoma and Ocular Hypertension

Cardiovascular Manifestations of Pseudoexfoliation Syndrome: A Narrative Review

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