2022
DOI: 10.3390/ijms231912010
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Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Abstract: The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) exp… Show more

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Cited by 21 publications
(12 citation statements)
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“…The presence of damaged photoreceptors and RPE may have resulted in the progressive thinning of the choroidal layers, as the RPE and photoreceptors required less nutrition from the choroid. This explanation may be comparable to that which has been reported for age-related macular degeneration [ 9 ].…”
Section: Discussionsupporting
confidence: 92%
“…The presence of damaged photoreceptors and RPE may have resulted in the progressive thinning of the choroidal layers, as the RPE and photoreceptors required less nutrition from the choroid. This explanation may be comparable to that which has been reported for age-related macular degeneration [ 9 ].…”
Section: Discussionsupporting
confidence: 92%
“…In this light, a therapy that targets RPD progression could be pivotal for AMD management. Considering that the RPE dysfunction was suggested as the main causative element in RPD pathogenesis, a subthreshold laser that preserves and stimulates RPE function could play a crucial role [ 116 , 117 ].…”
Section: Clinical Applicationsmentioning
confidence: 99%
“…In man, "… capillaries arise from the arterioles in Sattler's layer, each of which gives rise to a hexagonal (or lobular)-shaped domain of a single layer of capillaries, giving a path-like structure to the choriocapillaris" (Nickla & Wallman, 2010). With respect to the position of supplying arterioles and draining venules of the choriocapillaris hexagonal arrays (lobules) of the human eye, two main interpretations of the functional arrangement have been proposed: a lobule with a central venule surrounded by peripheral arterioles or a functional lobule with a central arteriole and peripheral venules (Fragiotta et al, 2022). In their study on the ocular microcirculation of the cat's eye, Risco and Nopanitaya (1980) elegantly demonstrate the lobular arrangement of the capillaries of the choriocapillaris.…”
Section: Resultsmentioning
confidence: 99%