1996
DOI: 10.1016/s0304-3940(96)13151-7
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Chromaffin granule membrane glycoprotein IV is identical with Ac45, a membrane-integral subunit of the granule's H+-ATPase

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Cited by 20 publications
(24 citation statements)
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“…Determination of the exact cleavage site has ruled out the previously reported cleavage site, which was based on N-terminal sequencing of mature bovine Ac45 (27). Our results indicate proAc45 is cleaved by furin after Arg-225, possibly subsequently trimmed by aminopeptidase activity.…”
Section: Discussionmentioning
confidence: 67%
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“…Determination of the exact cleavage site has ruled out the previously reported cleavage site, which was based on N-terminal sequencing of mature bovine Ac45 (27). Our results indicate proAc45 is cleaved by furin after Arg-225, possibly subsequently trimmed by aminopeptidase activity.…”
Section: Discussionmentioning
confidence: 67%
“…Ac45, encoded by Atp6ap1, is a V-ATPase accessory subunit particularly abundant in neuroendocrine tissues (26,27). Quantitative RT-PCR revealed highest expression of Ac45 in isolated islets of Langerhans as compared with nine other tissues (Fig.…”
Section: Impaired Processing Of Proproteins In the Furin-deficient Ismentioning
confidence: 96%
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“…ATP6S1 is the human homolog of a protein first characterized as a putative accessory subunit of the vacuolar H ϩ -ATPase complex in bovine chromaffin granules (11). Consistent with the conserved role of this complex in regulating pH throughout the secretory and endocytic pathways (16), the human protein is related closely to the corresponding molecules from the cow (92% similarity), rat (92% similarity), mouse (90% similarity), and Xenopus (77% similarity) (11,14,(17)(18)(19)(20). A single 2.8-kb transcript was detected by Northern analysis in most human tissues, with slightly increased levels in endocrine organs (Fig.…”
Section: Resultsmentioning
confidence: 80%
“…One of the gene products detected in the screen was ATP6S1, a putative subunit of the vacuolar H ϩ -ATPase complex (11,14,(17)(18)(19). The immunogenicity of this gene product was surprising, given its widespread expression in normal tissues and the absence of tumor-associated mutations or increased mRNA expression (data not shown).…”
Section: Discussionmentioning
confidence: 99%