We study the Picard group of Franke's category of quasi-periodic E 0 E-comodules for E a 2-periodic Landweber exact cohomology theory of height n such as Morava E-theory, showing that for 2p − 2 > n 2 + n, this group is infinite cyclic, generated by the suspension of the unit. This is analogous to, but independent of, the corresponding calculations by Hovey and Sadofsky in the E-local stable homotopy category. We also give a computation of the Picard group of In-complete quasi-periodic E 0 E-comodules when E is Morava E-theory, as studied by Barthel-Schlank-Stapleton for 2p − 2 ≥ n 2 and p − 1 n, and compare this to the Picard group of the K(n)-local stable homotopy category, showing that they agree up to extension.