2023
DOI: 10.1371/journal.pgen.1010627
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Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans

Abstract: Programmed DNA double-strand break (DSB) formation is essential for achieving accurate chromosome segregation during meiosis. DSB repair timing and template choice are tightly regulated. However, little is known about how DSB distribution and the choice of repair pathway are regulated along the length of chromosomes, which has direct effects on the recombination landscape and chromosome remodeling at late prophase I. Here, we use the spatiotemporal resolution of meiosis in the Caenorhabditis elegans germline a… Show more

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Cited by 13 publications
(7 citation statements)
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“…Yet, recombination foci seemingly associate with the axis 79 , suggestive of a post-DSB mechanism that recruits recombination intermediates to axes 80 . Consistently, irradiation-induced DSBs — which are not confined to axes — give rise to axis-associated recombination foci in mice, and a similar configuration may be present in irradiated worms 34, 63, 81 . The existence of post-DSB mechanisms for axial recruitment of recombination foci raises the question why DSB activity is focused on axes in most taxa.…”
Section: Discussionmentioning
confidence: 61%
“…Yet, recombination foci seemingly associate with the axis 79 , suggestive of a post-DSB mechanism that recruits recombination intermediates to axes 80 . Consistently, irradiation-induced DSBs — which are not confined to axes — give rise to axis-associated recombination foci in mice, and a similar configuration may be present in irradiated worms 34, 63, 81 . The existence of post-DSB mechanisms for axial recruitment of recombination foci raises the question why DSB activity is focused on axes in most taxa.…”
Section: Discussionmentioning
confidence: 61%
“…Yet, recombination foci seemingly associate with the axis 79 , suggestive of a post-DSB mechanism that recruits recombination intermediates to axes 80 . Consistently, irradiation-induced DSBswhich are not confined to axesgive rise to axis-associated recombination foci in mice, and a similar configuration may be present in irradiated worms 34,63,81 . The existence of post-DSB mechanisms for axial recruitment of recombination foci raises the question why DSB activity is focused on axes in most taxa.…”
Section: Evolutionary Comparison Suggests That Axial Localization Of ...mentioning
confidence: 55%
“…Perturbations to chromosome structure influence the frequency of DSBs in the genome and, hence, of COs, as has been observed for meiotic condensin mutants in C. elegans . 46 , 68 Studies in yeast suggest that histone H2A underexpression leads to location-specific disruptions in chromatin. 69 , 70 Therefore, we propose that his-47 decreased expression levels could potentially alter chromosome structure, which may be linked to the elevated levels of DSBs and increased CO designated sites observed following DEET exposure.…”
Section: Discussionmentioning
confidence: 99%