Chromatin priming elements direct tissue-specific gene activity prior to hematopoietic specification
Alexander Maytum,
Benjamin Edginton-White,
Peter Keane
et al.
Abstract:Tissue-specific gene regulation during development involves the interplay between transcription factors and epigenetic regulators binding to enhancer and promoter elements. The pattern of active enhancers defines the cellular differentiation state. However, developmental gene activation involves a previous step called chromatin priming which is not fully understood. We recently developed a genome-wide functional assay that allowed us to functionally identify enhancer elements integrated in chromatin regulating… Show more
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