Chromatographic and chromato–mass spectral characterization of amino acids derivatives formed via the interaction with dimethyl acetal of dimethylformamide

Abstract

A series of amino acids have been converted into the derivatives via interaction with dimethylformamide dimethyl acetal for gas chromatography identification. The derivatives have been for the first time characterized with mass spectra and retention indices corresponding to the standard nonpolar polydimethylsiloxane stationary phases. Basic features of mass spectroscopic fragmentation of the derivatives have been stated; the rules for interpretation of their gas chromatography retention indices have been figured out, including the additive scheme elements.

Unusual Regularity in GC Retention of Simple Amino Acid Derivatives

“…[2] and 1143 i.u. [21] were reported for methyl ester of N-dimethylaminomethylene-alanine and both publications indicated that glycine did not form such a derivative at standard conditions; it can be explained by specific chemical properties of glycine as the first member of the homologous series.…”