Chromatographic assay and pharmacokinetic studies of propofol in human serum

Avaliação da função pulmonar em pacientes submetidos à cirurgia cardíaca com circulação extracorpórea

“…Os reagentes utilizados no procedimento analítico apresentaram grau de Vários métodos têm sido descritos na literatura para a análise das concentrações plasmáticas de propofol utilizando cromatografia líquida de alta eficiência com detecção ultravioleta (UV) (KNIBBE et al, 1998;ZHANG et al, 1998;EMARA et al, 1999), fluorescência (CHAN et al, 1990;EL-YAZIGI et al, 1996;YEGANCH et al, 1997) ou eletroquímico (DOWRIE et al, 1996), e também utilizando cromatografia a gás com detector de massas (STETSON et al, 1993).…”

Formation of the N-methylpyridinium ether derivative of propofol to improve sensitivity, specificity and reproducibility of its detection in blood by liquid chromatography–mass spectrometry

“…These data are in good qualitative accordance to published pharmacokinetic studies [11,26] reporting a similar distribution and elimination kinetics. A characteristic distinction of this study was the occurrence of higher peak concentrations due to the application of arterial blood and short sampling intervals in the initial administration phase.…”

The use of CE‐electrochemiluminescence with ionic liquid for the determination of bioactive constituents in Chinese traditional medicine

“…In order to monitor and identify a drug abuser, Wu et al detected the contents of morphine and morphine-3b-D glucuronide in human urine by the CE technique [10]. To improve the separation efficiency of the opium alkaloids, CD was added into a CE separation system as an additive [11][12][13], and MEKC was also used for the separation of opium alkaloids [14][15][16][17]. By introducing a short water plug before the sample, Manetto et al improved the detection sensitivity of the opiate drugs in hair [18].…”