2018
DOI: 10.1002/pca.2761
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Chromatographic characterisation of 11 phytocannabinoids: Quantitative and fit‐to‐purpose performance as a function of extra‐column variance

Abstract: The bulk diffusion coefficients and van Deemter curves informed the development of a rapid quantitative method and will facilitate potential expansion to include additional compounds, including synthetic cannabinoids. The developed method can be implemented with low or standard extra-column variance UPLC configurations.

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Cited by 8 publications
(3 citation statements)
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“…The amounts of solvents used are greatly reduced, and as such, the amount of waste that needs to be disposed is minimal. Obtainable efficiency and specificity by SFC are comparable to that of HPLC (Geryk et al, 2015); using HPLC/DAD (two unique analytical methods for cannabinoids and other compounds fingerprinting in Cannabis (Peschel and Politi, 2015); using HPLC, for cannabinoids analysis in -marijuana nourishments‖ (Vandrey et al, 2015); using HPLC, for doing a comparative study between THCA and THC as percentage in C. sativa, in addition to, the storage temperature effect on cannabinoids stability (Taschwer and Schmid, 2015) UHPLC By the year 2018-A liquid chromatography coupled with tandem mass spectrometry (UPLC-MS) was used for quantifying cannabinoids (THC, CBD, THCA, CBDA and CBN) concentrations in mixed olive oil cannabis preparations (Carcieri et al, 2018); Pacifici et al used UHPLC for evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil (Carcieri et al, 2018;Noestheden et al, 2018a;Pacifici et al, 2018); UPLC method was used for simultaneous analysis of cannabinoid and synthetic cannabinoids in dietary supplements (Heo et al, 2016); Wang et al developed and validated an UHPLC-UV-MS method for determination of 11 acid and neutral cannabinoids in cannabis samples (Wang et al, 2018). Eleven cannabinoids were characterized in Cannabis matrix using quantitative and fit-to-purpose performance as a function of extra-column variance and UPLC technique.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The amounts of solvents used are greatly reduced, and as such, the amount of waste that needs to be disposed is minimal. Obtainable efficiency and specificity by SFC are comparable to that of HPLC (Geryk et al, 2015); using HPLC/DAD (two unique analytical methods for cannabinoids and other compounds fingerprinting in Cannabis (Peschel and Politi, 2015); using HPLC, for cannabinoids analysis in -marijuana nourishments‖ (Vandrey et al, 2015); using HPLC, for doing a comparative study between THCA and THC as percentage in C. sativa, in addition to, the storage temperature effect on cannabinoids stability (Taschwer and Schmid, 2015) UHPLC By the year 2018-A liquid chromatography coupled with tandem mass spectrometry (UPLC-MS) was used for quantifying cannabinoids (THC, CBD, THCA, CBDA and CBN) concentrations in mixed olive oil cannabis preparations (Carcieri et al, 2018); Pacifici et al used UHPLC for evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil (Carcieri et al, 2018;Noestheden et al, 2018a;Pacifici et al, 2018); UPLC method was used for simultaneous analysis of cannabinoid and synthetic cannabinoids in dietary supplements (Heo et al, 2016); Wang et al developed and validated an UHPLC-UV-MS method for determination of 11 acid and neutral cannabinoids in cannabis samples (Wang et al, 2018). Eleven cannabinoids were characterized in Cannabis matrix using quantitative and fit-to-purpose performance as a function of extra-column variance and UPLC technique.…”
Section: Resultsmentioning
confidence: 99%
“…Eleven cannabinoids were characterized in Cannabis matrix using quantitative and fit-to-purpose performance as a function of extra-column variance and UPLC technique. (Noestheden et al, 2018a); the bulk diffusion coefficients and van Deemter curves using UPLC were used for the development of a rapid quantitative method for determination of 11 cannabinoids (Noestheden et al, 2018b). Using a liquid chromatography coupled to tandem mass spectrometry on a QTRAP 4000; Di Marco Pisciottano et al developed a fast method for determination of nine phytocannabinoids in beverages and food derived from Cannabis sativa (Di Marco Pisciottano et al, 2018).…”
Section: Resultsmentioning
confidence: 99%
“…Important topics to resolve include: defining what the analytical procedure is to measure [88], for example the complement of cannabinoids to be included [89] and expected interfering materials [49], as well as how transferrable the analytical method is among heterogeneous CME matrices. The inclusion/exclusion of chemical constituents for quantitative assessment and potency testing within Cannabis drug forms will be application specific and dependent on a number of factors, including the genetic uniformity and chemotypic heterogeneity of breeding materials used in biopharmaceutical manufacture.…”
Section: Collaborative Research Initiativementioning
confidence: 99%