Chromatographic Determination of Sugar Probes Used for Gastrointestinal Permeability Test by Employing Nickel‐Copper Nanoalloy Embedded in Carbon Film Electrodes

Shiba, Shoichi; Maruyama, Rina; Kamata, Toshihide; Kato, Dai; Niwa, Osamu

doi:10.1002/elan.201800072

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…Overall, our selective electrodeposition method can fabricate Pt/Au, Pt/Pd, Pd/Au, Au/Pd, Ni/Au, and Ni/Pd heterodimers semiembedded in flat conductive C film. The cosputtering method can embed a wide variety of small (2–5 nm) metal nanoparticles in C film including Pt, , Pd, Au, Ir, Ni, Cu, Co, and Ni–Cu alloy , nanoparticles, with free control over the amount of embedded nanoparticles and the alloy composition. Therefore, a wide variety of metallic heterodimers could also be formed by the selective electrodeposition method.…”

Section: Results and Discussionmentioning

confidence: 99%

Vertically Oriented Metallic Heterodimer Array Semiembedded in Flat Conductive Carbon Film for Electrochemical Application

et al. 2022

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General synthesis of a highly oriented metallic heterodimer array based on a selective electrodeposition technique onto a metal nanoparticle-embedded carbon film is proposed, which enables the preparation of heterodimers with a wide variety of metal combinations. This method requires no surfactant, capping agent, organic solvent, or heat treatment. As a representative metal combination, a nickel (Ni)/palladium (Pd) heterodimer array was prepared by selective electrodeposition of Ni nanoparticles (Ni NPs) on top of partially exposed Pd NPs embedded in carbon film electrodes fabricated by a cosputtering technique. Such a selective electrodeposition becomes possible by utilizing the difference in electrodeposition overpotentials between carbon and Pd NP surfaces. X-ray photoelectron spectroscopy revealed a charge transfer from Ni NPs to Pd NPs, implying that the catalytic and optical properties can be expected to be controllable. The formed heterodimer array structure was mechanically stable against ultrasonication in ethanol for over 1 h because most parts of the Pd NPs were tightly embedded in the carbon film. After conversion from Ni to nickel hydroxide (Ni(OH)2), the electrode showed high electrocatalytic activity toward glucose oxidation, with a higher turnover rate and lower overpotential compared to Ni(OH)2 electrodeposited on pure carbon film electrodes.

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Section: Results and Discussionmentioning

confidence: 99%

Vertically Oriented Metallic Heterodimer Array Semiembedded in Flat Conductive Carbon Film for Electrochemical Application

et al. 2022

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“…The obtained detection limits are about 1-2 orders of magnitude improved than those obtained with Au (by pulse amperometric detection) and Ni bulk electrodes, which is sufficient to detect diagnostic marker sugars in urine samples. 65…”

Section: Carbon Film Electrodes Embedded With Ni/cu Nanoalloymentioning

confidence: 99%

Sputter Deposited Nanocarbon Film Electrodes for Electrochemical Analysis of Biomolecules

NIWA,

OHTA,

SHIBA

et al. 2024

Electrochemistry

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Carbon-based electrode materials have been widely applied for the electrochemical analysis of biomolecules. In addition to traditional carbon electrodes such as glassy carbon and carbon paste, a wide variety of carbon materials such as nanocarbons and boron doped diamond (BDD) electrodes have been employed for electrochemical analysis and biosensors in the last 25 years. Of the carbon electrode materials, carbon films are practically advantageous because they can be fabricated reproducibly with a wide range of shapes and sizes. In this paper, we report the application of sputter deposited nanocarbon film electrodes for the electrochemical analysis of biomolecules. The pure nanocarbon film electrodes have been employed for detecting DNA methylation, and lipopolysaccharides (LPS). Nitrogen-containing carbon films show improved electrochemical activity for biomolecules and excellent biocompatibility with interferents such as proteins. Metal nanoparticle embedded or modified carbon film electrodes show excellent electrocatalytic performance with sugars.

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“…However, it was also found that NEPCSs provide an overall current response for all saccharides tested. Therefore, a pre-separation step is necessary if quantification of individual saccharides is required in terms of their application in food and environmental analysis, where they could serve as sensitive electrochemical detection systems [28][29][30][31]. ), uric acid (≥99%), and suspensions of monodisperse polystyrene beads with particle sizes of 200 or 500 nm were purchased from Sigma Aldrich (Prague, Czech Republic).…”

Section: Introductionmentioning

confidence: 99%

Screen-Printed Carbon Electrodes with Macroporous Copper Film for Enhanced Amperometric Sensing of Saccharides

Metelka

Vlasáková

Smarzewska

et al. 2022

Sensors

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A porous layer of copper was formed on the surface of screen-printed carbon electrodes via the colloidal crystal templating technique. An aqueous suspension of monodisperse polystyrene spheres of 500 nm particle diameter was drop-casted on the carbon tracks printed on the substrate made of alumina ceramic. After evaporation, the electrode was carefully dipped in copper plating solution for a certain time to achieve a sufficient penetration of solution within the polystyrene spheres. The metal was then electrodeposited galvanostatically over the self-assembled colloidal crystal. Finally, the polystyrene template was dissolved in toluene to expose the porous structure of copper deposit. The morphology of porous structures was investigated using scanning electron microscopy. Electroanalytical properties of porous copper film electrodes were evaluated in amperometric detection of selected saccharides, namely glucose, fructose, sucrose, and galactose. Using hydrodynamic amperometry in stirred alkaline solution, a current response at +0.6 V vs. Ag/AgCl was recorded after addition of the selected saccharide. These saccharides could be quantified in two linear ranges (0.2–1.0 μmol L−1 and 4.0–100 μmol L−1) with detection limits of 0.1 μmol L−1 glucose, 0.03 μmol L−1 fructose, and 0.05 μmol L−1 sucrose or galactose. In addition, analytical performance of porous copper electrodes was ascertained and compared to that of copper film screen-printed carbon electrodes, prepared ex-situ by the galvanostatic deposition of metal in the plating solution. After calculating the current densities with respect to the geometric area of working electrodes, the porous electrodes exhibited much higher sensitivity to changes in concentration of analytes, presumably due to the larger surface of the porous copper deposit. In the future, they could be incorporated in detectors of flow injection systems due to their long-term mechanical stability.

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Chromatographic Determination of Sugar Probes Used for Gastrointestinal Permeability Test by Employing Nickel‐Copper Nanoalloy Embedded in Carbon Film Electrodes

Cited by 6 publications

References 60 publications

Vertically Oriented Metallic Heterodimer Array Semiembedded in Flat Conductive Carbon Film for Electrochemical Application

Vertically Oriented Metallic Heterodimer Array Semiembedded in Flat Conductive Carbon Film for Electrochemical Application

Sputter Deposited Nanocarbon Film Electrodes for Electrochemical Analysis of Biomolecules

Screen-Printed Carbon Electrodes with Macroporous Copper Film for Enhanced Amperometric Sensing of Saccharides

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