Chromatographic Fingerprinting Analysis of Secondary Metabolites Present in Ethanolic Extract of <i>Tabernaemontana divaricata</i> (L.) R. Br. by HPTLC Technique

Kannappan, Poornima; Palanisamy, Chella Perumal; Sowmya, S; Kanniappan, Gopalakrishnan Velliyur

doi:10.1080/22297928.2017.1284608

Cited by 6 publications

(1 citation statement)

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“…Plants have a long history of use for the treatment of human diseases, particularly cancer, which is a lethal disease that causes deaths in individuals at a high rate [ 6 – 8 ]. Several medicinal plants have been reported to exhibit a variety of pharmacological and/or life functions such as antioxidant, antimicrobial, anti-inflammatory, anticancer, and antidiabetic, due to the presence of some active phytocompounds and compounds that possess aromatic hydroxylated rings [ 9 – 11 ]. The bioactive elements play an essential function in drug discovery programs in manufacturing medicine [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] (5E,7E)‐4,5,6 Trihydroxy‐3‐(hydroxymethyl)tetrahydro‐2H‐pyran‐2‐ylheptadeca‐5,7‐dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Metastatic Signaling Mechanisms

Palanisamy

Cui

Zhang

et al. 2022

Bioinorganic Chemistry and Applications

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Bioactive compound (5E,7E)-4,5,6 trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate (compound 2) was isolated from Euclea crispa (E. crispa) by the chromatographic methods. Further, the compound was confirmed by spectroscopic techniques such as ultraviolet-visible (UV/Vis) spectrometer, Fourier transform infrared (FTIR) spectrometer, and 1H and 13C nuclear magnetic resonance (NMR). Compound 2 exhibited a significant antioxidant activity with IC50 values. It restrained the auxesis of HO-8910 cells in a shot-dependent mode. CXCR4, HER2, and Akt proteins involved in cell proliferation and metastasis were found to be significantly reduced ( p < 0.05 ). The protein that is responsible for the death of cells (Bcl-2 and Bcl-xL) was reduced ( p < 0.05 ), while the protein expression of p53 and caspase-9 was increased ( p < 0.05 ) in compound 2-treated HO-8910 cells. The results of molecular docking analysis showed the binding affinity with CXCR4 and HER2. Thus, compound 2 can serve as a promising chemotherapeutic agent for the intervention of ovarian cancer. The findings of this study conclude that compound 2 from E. crispa might work as a potential antioxidative and chemotherapeutic agent. The in vivo studies and attempts will pave way for this compound to be an effective drug hereafter.

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Section: Introductionmentioning

confidence: 99%