Chromatographic Reactors

Abstract

Chromatographic reactors integrate chemical reaction and chromatographic separation in one apparatus. This offers potential for process intensification, especially in the case of equilibrium reactions. Different types of discontinuous and continuous processes as well as modeling of chromatographic reactors are described. Synthesis and design of this processes is very much influenced and often restricted by the type of reaction and the operating window which is set by the individual operating conditions for chemical reaction, mass separation, and equipment design. Integrated chromatographic reactors should be considered if chromatography is the favored separation process for a conventional sequential process design. Preparative chromatographic reactors are known for liquid‐ and gas‐phase processes. Laboratory‐scale applications are described. Analytical chromatographic reactors are used to determine reaction rate constants and kinetics, and to screen chromatographic systems and operating conditions for preparative applications. 1. Introduction 2. Types of Chromatographic Reactors 3. Modeling of Chromatographic Reactors 3.1. Adsorption Isotherm and Reaction Kinetics 3.2. Modeling the BCR 3.3. Modeling Simulated Moving Bed Chromatographic Reactors 3.4. Process control 4. Synthesis of Preparative Chromatographic Reactors 4.1. Process Principles 4.2. Type of Reaction 5. Design of Preparative Chromatographic Reactors 5.1. Design of the Process 5.2. Choice of Operating Conditions 6. Preparative Chromatographic Reactors 6.1. Applications of Gas Chromatographic Reactors 6.2. Application of Liquid Chromatographic Reactors 7. Analytical Chromatographic Reactors 7.1. Determination of Rate Constants 7.2. Enzymatic Reactions 7.3. Characterization of the Stationary Phase 7.4. Examination of Fast Equilibrium Reactions 7.5. Examination of Solvent Effects

Analysis of Liquid Chromatography Considering a Linear Single-Component Heterogeneous-Type Reactive General Rate Model

“…Reactive chromatography is a branch of chromatography in which separation is handled in the presence of chemical or biochemical reactions. In this technique, not only the conversion of reactants is improved but also the high purity of products is achieved. − Both homogeneous and heterogeneous types of processes exist in reactive chromatography. In a chromatographic reactor based on a single-component heterogeneous reaction, the reaction takes place on a stationary phase, while the mobile phase carries the reactants through the reactor.…”

Irreversible and Reversible Reactions in a Liquid Chromatographic Column: Analytical Solutions and Moment Analysis

“…The work was extended by Binous and McCoy from two interacting isomers to three-component systems. Several other contributions on chromatographic reactors with different focal points were also published. ,− …”