Chromatographic Reactors

Durch die Integration einer chemischen oder biochemischen Reaktion und einer chromatographischen Trennung in einem gemeinsamen Apparat ist es möglich, die Gleichgewichtslimitierung der Reaktion zu überwinden und die Trenneffektivität zu erhöhen. Verschiedene prozesstechnische Varianten des chromatographischen Reaktors werden vorgestellt. Aufgrund der komplexen Zusammenhänge sind Modellierung und Simulation wichtige Werkzeuge bei der Entwicklung und Gestaltung der Prozesse. Eine Übersicht über die zur Verfügung stehenden Modellansätze wird gegeben. Ein Vergleich der verschiedenen chromatographischen Simulated Moving Bed (SMB)‐Reaktoren erfolgt am Beispiel der Glucose‐Isomerisierung. In Abhängigkeit von der jeweiligen Reinheitsanforderung an den gewonnenen Fructose‐Sirup bieten unterschiedliche Integrationsgrade von Reaktion und Trennung Vorteile.

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“…An der Veresterung von b-Phenylethylalkohol und der Glucose-Isomerisierung ist die Validierung des Prozessmodells erfolgt [43,44]. …”

Section: Modell Des Smb-reaktorsunclassified

Vergleich chromatographischer Reaktorkonzepte

Borren

Schmidt–Traub

2004

Chemie Ingenieur Technik

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“…Reactive chromatography is an integrated process in which chemical or biochemical reactions are combined with the chromatographic separation. − This technique improves the conversion of reactants and purity of products and, therefore, remained a source of attraction to several researchers in the past few decades. ,,− The chemical reactions can be of two types, such as homogeneous and heterogeneous. For understanding the basic principle of a fixed-bed chromatographic reactor, let us consider a single column reactor and a reversible reaction of the type A⇄B.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Linear General Rate Model of Reactive Chromatography for Core–Shell Adsorbents

Qamar

Bashir

Perveen

et al. 2017

Ind. Eng. Chem. Res.

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This article presents semi-analytical solutions of a linear general rate model for fixed-bed liquid chromatographic reactors packed with core-shell particles. The model considers axial dispersion, interfacial mass transfer, intraparticle diffusion, linear adsorption, heterogeneous irreversible and reversible reactions, and injection of rectangular pulses. The Laplace transformation and eigen-decomposition technique are simultaneously applied to derive analytical solutions. The numerical Laplace inversion is applied for back transforming solutions in the actual time domain. A high resolution finite volume scheme is used to numerically approximate the model equations. Different case studies of reactive chromatography are considered to analyze the effect of core radius fraction on the elution profiles.

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“…The technique is successfully employed to significantly improve the process performance of many multifunctional reactors. It reduces capital investment, equipment size, cost, energy, pollution and waste, while improving productivity and purity. − …”

Section: Introductionmentioning

confidence: 99%

Numerical Approximation of a Two-Dimensional Nonlinear and Nonequilibrium Model of Reactive Chromatography

Qamar

Perveen

Seidel‐Morgenstern

2016

Ind. Eng. Chem. Res.

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A two-dimensional nonlinear and non-equilibrium model of liquid chromatography is numerically approximated to simulate the dynamics of multi-component mixtures in a fixed-bed isothermal liquid chromatographic reactor. The mathematical model is formed by a system of nonlinear convection-diffusion-reaction partial differential equations coupled with differential and algebraic equations. A semi-discrete high resolution finite volume scheme is applied to solve the model equations. The scheme is second order accurate in axial and radial coordinates. The resulting system of ordinary differential equations is solved by a second order accurate Runge-Kutta method. The proposed scheme capably captures narrow peaks and sharp discontinuities in the concentration profiles. Radial gradients were not considered in the pervious studies which are particularly important in the case of non-perfect injections. Several test problems of heterogeneously catalyzed reversible reactions are carried out. The considered case studies include three and four-component elution assuming hypothetical injections of the reactants in inner or outer sections of the column inlet cross-section. The developed numerical algorithm and results are useful tools for further improvements in reactive chromatography.

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Chromatographic Reactors

Cited by 7 publications

References 70 publications

Vergleich chromatographischer Reaktorkonzepte

Vergleich chromatographischer Reaktorkonzepte

Analysis of Linear General Rate Model of Reactive Chromatography for Core–Shell Adsorbents

Numerical Approximation of a Two-Dimensional Nonlinear and Nonequilibrium Model of Reactive Chromatography

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