Chromatographic study of heparin preparations

Abstract

Heparin preparations used in clinics of our country (produced in Minsk, Kaunass, Baku, Hungary and Czechoslovakia) differ in their biological activity. Heparin is a variable molecular weight polymer of about 17,000 daltons. Its monomer unit consists of a-glucuronic acid esterified with another sulfuric acid at carbon 2, glucoseamine esterified with sulfuric acid at carbon 6 and at the amino group of carbon 2, and L-iduronic acid. The remains of glucuronic acid and glucosamine, iduronic acid and glucosamine are linked by glycosidic a (1 - 4) bonds.