Chromatographically identified alcohol‐induced haemoglobin adducts as markers of alcohol abuse among women

Hurme, Liisa; Seppä, Kaija; Rajaniemi, Hannu; Sillanaukee, Pekka

doi:10.1046/j.1365-2362.1998.00258.x

Cited by 11 publications

(7 citation statements)

References 29 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristic ␣-and ␤-chains in this fraction probably arise partly from overlapping of the highly intense HbA peak. HbA 1d3 is reported to be increased in female heavy drinkers and in alcoholic individuals, but the increase is not statistically significant (11 ). The first metabolite of ethanol, acetaldehyde, is known to form adducts with Hbs (10 ).…”

Section: Discussionmentioning

confidence: 99%

“…There is no accurate information about the globin chains of HbA 1d1 , HbA 1d2 , and HbA 1e available in the literature. Possibly, HbA 1d1 contains a globin chain modified by acetaldehyde (11 ). On the other hand, the well-studied HbA 1d3 is composed of at least 2 components, HbA 1d3a and HbA 1d3b , containing a carbamylated (urea adduct) ␣-chain and a glycated minor Hb (4 ).…”

mentioning

confidence: 99%

“…For example, HbA 1c is a marker for diabetes mellitus (1,17 ); HbA 1d3a and HbA 1d3b are increased in uremic and diabetic patients, respectively (4 ); and the controversial influence of Hb-acetaldehyde adducts on HbA 1d3 in female heavy drinkers has been reported (4,11 ). HbF is increased in hereditary persistence of fetal Hb, ␤-thalassemia intermedia, ␤-thalassemia major, and specific drug treatments (18 ).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Zurbriggen¹,

Schmugge²,

Schmid³

et al. 2005

Clinical Chemistry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Zurbriggen¹,

Schmugge²,

Schmid³

et al. 2005

Clinical Chemistry

View full text Add to dashboard Cite

“…The percentage of haemoglobin comprising Hba1a2 or HbA1d1 is more sensitive at distinguishing between social and heavy drinkers than a raised plasma ferritin concentration, at least among women, but these values are not measured routinely. 11 Dorevitch Pathology, Melbourne, conducted the iron studies.…”

Section: Discussionmentioning

confidence: 99%

Post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers.

Peach

Bath

1999

J Clin Pathol

View full text Add to dashboard Cite

Background-Raised plasma ferritin concentrations occur unexpectedly during iron studies done by primary care physicians. Plasma ferritin concentration has been positively associated with alcohol use among men. Aim-To determine the post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers. Methods-The subjects were 152 men, randomly selected from a city's electoral roll. Nineteen (12.5 (2.7)%, mean (SEM)) admitted to drinking hazardously. The pretest probability of a man being a hazardous drinker was 0.125. This was converted to pretest odds of 0.14. The likelihood ratio (the ratio of the probability of obtaining a raised plasma ferritin concentration in a hazardous drinker (sensitivity) to the probability of obtaining a raised plasma ferritin concentration in a nonhazardous drinker (1−specificity)) was calculated for diVerent plasma ferritin cut oV points. Results-A plasma ferritin level of > 652 µg/l gave the largest likelihood ratio, 4.16. Post-test odds were obtained by multiplying the pretest odds (0.14) by the likelihood ratio (4.16). A plasma ferritin level of > 652 µg/l had a post-test odds for a man being a hazardous drinker of 0.58. This was converted to a post-test probability of 0.37. Conclusions-Inquiries could usefully be made into the alcohol consumption of men with a plasma ferritin concentration > 652 µg/l, as approximately one in three would admit to drinking hazardously. (J Clin Pathol 1999;52:853-855)

show abstract

“…Acetaldehyde, the product of ethanol oxidation, binds to many proteins including albumin and hemoglobin. Previous studies have indicated increased amounts of acetaldehyde-hemoglobin adducts in the erythrocytes of female alcohol abusers (5).…”

mentioning

confidence: 95%

Mean cell volume and gamma‐glutamyl transferase are superior to carbohydrate‐deficient transferrin and hemoglobin‐acetaldehyde adducts in the follow‐up of pregnant women with alcohol abuse

Sarkola¹,

Eriksson²,

Niemelä³

et al. 2000

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Chromatographically identified alcohol‐induced haemoglobin adducts as markers of alcohol abuse among women

Abstract: This study indicates that at least three alcohol-induced haemoglobin adducts occurring in vivo can be measured with promising diagnostic efficiency among women.

Cited by 11 publications

References 29 publications

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers.

Mean cell volume and gamma‐glutamyl transferase are superior to carbohydrate‐deficient transferrin and hemoglobin‐acetaldehyde adducts in the follow‐up of pregnant women with alcohol abuse

Contact Info

Product

Resources

About