Chromatography of Non-Steroidal Anti-Inflammatory Drugs: New Achievements

Abstract

The newest results in the chromatographic analysis of non-steroidal anti-inflammatory drugs present in various organic and inorganic accompanying matrices are collected and critically evaluated. Examples for the application of pre-concentration and pre-purification methods for the enhancement of the selectivity and sensitivity of chromatographic technologies are presented. The advantages and disadvantages of the different chromatographic methods are discussed and the separation capacities of the techniques are compared. The application of various chromatographic procedures for the separation and quantitative determination of non-steroidal anti-inflammatory drug (ibuprofen, diclofenac, genfibrozil, ketoprofen, diflunisal, indoprofen, fenoprofen, meclofenamic acid, naproxen, mexiletin) is discussed in detail.