Chrome nitride coating reduces wear of small, spherical CrCoMo metal-on-metal articulations in a joint simulator

Thorkildsen, Rasmus; Reigstad, Ole; Røkkum, Magne

doi:10.1177/1753193416674161

Cited by 3 publications

(2 citation statements)

References 33 publications

(38 reference statements)

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“…Other options to minimize metallic wear have been reported in the literature. In a joint simulator, use of chromium nitride coating could reduce metallic wear [ 32 ]. Advanced superlattice ceramic coating resulted in decreased metal ion levels, compared to uncoated MoM surfaces [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum

Fortmann,

Göen,

Wiesner

et al. 2023

PLoS ONE

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Introduction Previous studies demonstrated a release of toxic metals, e.g. nickel and chromium, from stainless steel bars used for minimally invasive repair of pectus excavatum (MIRPE). In the present study, we investigated the impact of titanium nitride coating on the metal release and exposure of MIRPE patients. Material and methods We analyzed the courses of nickel and chromium levels in blood, urine and local tissue in patients undergoing MIRPE with a titanium nitride coated pectus bar between 03/2017 and 10/2018. Sample collection was scheduled prior to MIRPE, at defined postoperative time points and at bar removal. Additionally, we evaluated irritative symptoms. Results were compared to a control group who received uncoated stainless steel bars in a previous time period (03/2015–02/2017). Results 12 patients received coated pectus bars (mean age 15.7 years). The control group included 28 patients. After implantation of a titanium nitride coated bar, significant increase in systemic nickel and chromium levels after one, two and three years was noted. In an interim analysis one year after MIRPE, we observed patients with coated bars to have significantly elevated trace metal values compared to the control group. This elevation persisted throughout the observation period. Tissue metal values were also significantly increased. Irritative symptoms occurred significantly more often in study patients compared to controls (50.0% vs. 14.3%). Conclusions Coating of pectus bars with titanium nitride failed to reduce metal contamination after MIRPE. Instead, it resulted in a significant increase of trace metal levels after MIRPE, compared to patients with stainless steel bars, which may be explained by wear of the coating and inter-component mobilization processes.

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Section: Discussionmentioning

confidence: 99%

Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum

Fortmann,

Göen,

Wiesner

et al. 2023

PLoS ONE

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show abstract

“…Against this, many strategies, including new types of prosthesis, wear-resistant materials, surgical methods, fixation techniques, and rehabilitation management improvements, have been developed and applied in TJA [17][18][19][20][21]. These strategies greatly avoid joint prosthesis loosening and wear, but wear still cannot be solved completely.…”

Section: Discussionmentioning

confidence: 99%

Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Formation

Zhu

Wang

et al. 2021

Journal of Immunology Research

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Wear particle-induced periprosthetic osteolysis is mainly responsible for joint replacement failure and revision surgery. Curculigoside is reported to have bone-protective potential, but whether curculigoside attenuates wear particle-induced osteolysis remains unclear. In this study, titanium particles (Ti) were used to stimulate osteoblastic MC3T3-E1 cells in the presence or absence of curculigoside, to determine their effect on osteoblast differentiation. Rat osteoclastic bone marrow stromal cells (BMSCs) were cocultured with Ti in the presence or absence of curculigoside, to evaluate its effect on osteoclast formation in vitro. Ti was also used to stimulate mouse calvaria to induce an osteolysis model, and curculigoside was administrated to evaluate its effect in the osteolysis model by micro-CT imaging and histopathological analyses. As the results indicated, in MC3T3-E1 cells, curculigoside treatment attenuated the Ti-induced inhibition on cell differentiation and apoptosis, increased alkaline phosphatase activity (ALP) and cell mineralization, and inhibited TNF-α, IL-1β, and IL-6 production and ROS generation. In BMSCs, curculigoside treatment suppressed the Ti-induced cell formation and suppressed the TNF-α, IL-1β, and IL-6 production and F-actin ring formation. In vivo, curculigoside attenuated Ti-induced bone loss and histological damage in murine calvaria. Curculigoside treatment also reversed the RANK/RANKL/OPG and NF-κB signaling pathways, by suppressing the RANKL and NF-κB expression, while activating the OPG expression. Our study demonstrated that curculigoside treatment was able to attenuate wear particle-induced periprosthetic osteolysis in in vivo and in vitro experiments, promoted osteoblastic MC3T3-E1 cell differentiation, and inhibited osteoclast BMSC formation. It suggests that curculigoside may be a potential pharmaceutical agent for wear particle-stimulated osteolysis therapy.

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Explant analysis of a chromium nitride coated metal-on-metal total wrist replacement: A case study

Joyce,

Kandemir,

McGuire

et al. 2024

Proc Inst Mech Eng H

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Explant analysis can provide important understanding of how artificial joints perform in the human body. The articulating surfaces of the metacarpal head and the radius cup from a chromium nitride coated metal-on-metal Motec wrist implant were analysed. Due to bone resorption and aseptic loosening, the implant was removed after 6 years in the patient, and metallosis was observed during removal. Visually, some areas of the articulating surfaces appeared polished, others were dulled. A chemical composition analysis of the metacarpal head showed that the polished surfaces were chromium rich, implying this surface was the original chromium nitride coating, whereas the dulled surfaces were cobalt rich, indicating the underlying cobalt chromium substrate. In addition, the underlying cobalt chromium substrate was an order of magnitude rougher than the polished surface, indicating the scale of damage to it. It is speculated that the loss of the coating, and the subsequent damage to the underlying substrate due to a third-body wear process, led to osteolysis and the metallosis seen at revision surgery.

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Chrome nitride coating reduces wear of small, spherical CrCoMo metal-on-metal articulations in a joint simulator

Cited by 3 publications

References 33 publications

Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum

Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum

Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Formation

Explant analysis of a chromium nitride coated metal-on-metal total wrist replacement: A case study

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