Chromium-Induced Lymph Node Histiocytic Proliferation After Hip Replacement

Munichor, Mariana; Cohen, Hector; Volpin, Gershon; Kerner, Hedviga; Iancu, Theodore C.

doi:10.1159/000326515

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…This condition can assume one of three patterns, depending on the causative agent: follicular hyperplasia, which is associated with B-cell activation, paracortical hyperplasia that shows reactive changes within the T-cell regions or sinus histiocytosis [33]. Additionally, some researchers reported the cases of sinus histiocytosis in regional lymph nodes induced by the implantation of prostheses contained chromium, cobalt and titanium [34,35]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

et al. 2011

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BackgroundMagnesium alloys as biodegradable implant materials received much interest in recent years. It is known that products of implant degradation can induce several types of immune response. Hence, the aim of this study was to examine the morphological changes of efferent lymph nodes after implantation of different resorbable magnesium alloys (MgCa0.8, LAE442) in comparison to commercially available resorbable (PLA) and non-resorbable (titanium) implant materials as well as control groups without implant material.MethodsThe different implant materials were inserted intramedullary into the rabbit tibia. After postoperative observation periods of three and six months, popliteal lymph nodes were examined histologically and immunhistologically and compared to lymph nodes of sham operated animals and animals without surgery. Haematoxylin and eosin staining was performed for cell differentiation. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection, mouse anti-CD68 primary antibodies for macrophage detection. Evaluation of all sections was performed applying a semi quantitative score.ResultsThe histological evaluation demonstrated low and moderate levels of morphological changes for both magnesium alloys (LAE442 and MgCa0.8). Higher than moderate values were reached for titanium in sinus histiocytosis and histiocytic apoptosis (3 months) and for PLA in histiocytic apoptosis (3 and 6 months). The immune response to all investigated implants had a non-specific character and predominantly was a foreign-body reaction. LAE442 provoked the lowest changes which might be due to a lower degradation rate in comparison to MgCa0.8. Therewith it is a promising candidate for implants with low immunogenic potential.ConclusionBoth examined magnesium alloys did not cause significantly increased morphological changes in efferent lymph nodes in comparison to the widely used implant materials titanium and PLA. LAE442 induced even lower immunological reactions. Therewith MgCa0.8 and especially LAE442 are appropriate candidates for biomedical use.

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Section: Introductionmentioning

confidence: 99%

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

et al. 2011

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“…cobalt, vanadium, and chromium) are released from prostheses and have been implicated in the development of systemic symptoms, this review will focus on cobalt toxicity. 30,[39][40][41] Specifically, in this article, we will review the use of cobalt alloys in THA, highlighting the following topics: historical context of cobalt in THA; mechanisms of ion release; and the pathophysiology of toxicity.…”

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confidence: 99%

Systemic cobalt toxicity from total hip arthroplasties

Cheung

Banerjee

Cherian

et al. 2016

The Bone & Joint Journal

101

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“…As with inflammation from other causes, metallosis can lead to involvement of regional lymph nodes. Chromium containing histiocytes have been demonstrated in the enlarged pelvic lymph nodes of a patient 8 years after hip arthroplasty (41).…”

Section: Local Effect Of Metalsmentioning

confidence: 94%

Metallosis: metal ion release from metal-on-metal joint surface replacement - current concerns and future problems

Manning

2011

Biomedical Reviews

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Since its innovation, joint replacement surgery has offered relief from the pain and functional limitation of destructive or degenerate joint disease. The search for the ideal material continues over 120 years later. Recently, using metal-on-metal bearings for younger patients has become the trend to avoid excess wear in high demand patients in the hope of reducing the need to revision surgery. Initial evidence suggested these prostheses offered a durable, functional safe joint that was less likely to be revised than the standard metal and polyethylene joint. A body of evidence is growing rapidly to suggest that metal-on-metal joints are associated with local tissue reactions -metallosis -cellular toxicity, increased serum metal ion concentrations, organ deposition of metal ions, higher rather than lower rates of revision surgery and no functional advantage over any other type of joint replacement. We will consider the reasons for metal ion release; the cellular, local tissue and systemic effects of metal ions and the patient risk and presentation. From the evidence reviewed, serious consideration should be given to the future use of metal-on-metal joint bearings and a suggested follow up plan for patients with such joints is identified and reproduced.

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Chromium-Induced Lymph Node Histiocytic Proliferation After Hip Replacement

Cited by 15 publications

References 8 publications

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

Systemic cobalt toxicity from total hip arthroplasties

Metallosis: metal ion release from metal-on-metal joint surface replacement - current concerns and future problems

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