Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

Selçuk, Mustafa Yavuz; Aygen, Bilge; Doğukan, Ayhan; Tuzcu, Zeynep; Akdemir, Fatih; Komorowski, James; Atalay, Mustafa; Şahin, Kazım

doi:10.1186/1743-7075-9-30

Cited by 40 publications

(31 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For above reasons, some organic trivalent chromium compounds such as chromium(III) picolinate (CrPic) have been used as nutritional supplement for providing Cr(III) to human since the CrPic has low toxicity and high bioavailability . Some studies have shown that CrPic has a protective role against diabetic nephropathy and exerts antidiabetic activities, although these results are disputed . On the other hand, Cr(VI) is considered to be extremely toxic to organism since it has strong mutagenic and carcinogenic effects .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of Cr(III), Cr(VI), and chromium picolinate in foods using capillary electrophoresis‐inductively coupled plasma mass spectrometry

Chen

et al. 2015

Electrophoresis

View full text Add to dashboard Cite

We herein reported a method for the simultaneous detection of trace Cr(VI), Cr(III), and chromium(III) picolinate (CrPic) in foods using CE-ICP-MS together with ultrasonic-assisted extraction. The Cr(III) (Cr(3+) ) was chelated with trans-1,2-diaminocyclohexane-N,N,N´,N´-tetraacetic acid (DCTA) to form a single charged Cr-DCTA(-) complex. Then, Cr(VI) (CrO4 (2-) ), Cr-DCTA(-) , and CrPic were separated by CE within 8 min under a separation voltage of -13 KV followed by their monitoring with ICP mass spectrometer (ICP-MS). The proposed method is simple, effective, and sensitive. It has an instrument detection limit of 0.10, 0.18, and 0.20 ngCr/mL for Cr(VI), Cr(III), and CrPic, respectively. With the help of the methods, we have successfully determined Cr(VI), Cr(III), and CrPic in nutritional supplement (CrPic yeast tablet) with an RSD (n = 5) <6% and a recovery of 93-103%. The experimental results showed that CrPic was the main speciation of chromium in the nutritional supplement, with a concentration of 1514.6 μg Cr/g.

show abstract

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of Cr(III), Cr(VI), and chromium picolinate in foods using capillary electrophoresis‐inductively coupled plasma mass spectrometry

Chen

et al. 2015

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…Trivalent chromium is an essential trace metal that has been shown to lower oxidative stress and improve glucose and lipid metabolism (29)(30)(31)(32)(33)(34)(35). Chromium picolinate Cr(pic)3 is a widely consumed and well absorbed form of trivalent chromium that is widely promoted as a dietary supplement for adjunctive therapy for Type 2 diabetes (29,30).…”

Section: Introductionmentioning

confidence: 99%

“…Chromium picolinate Cr(pic)3 is a widely consumed and well absorbed form of trivalent chromium that is widely promoted as a dietary supplement for adjunctive therapy for Type 2 diabetes (29,30). Cr(pic)3 supplementation has the potential to reduce cellular oxidative stress (30,31), levels of proinflammatory cytokines (32)(33)(34), blood cholesterol and triglycerides in diabetes (26,32). Whereas Cr(pic)3 has been extensively investigated in relation to carbohydrate and lipid metabolism, there are only a few studies devoted to the effects of Cr (pic)3 on the cardiovascular system (36,37).…”

Section: Introductionmentioning

confidence: 99%

Preventive Effects of Selenium Yeast, Chromium Picolinate, Zinc Sulfate and their Combination on Oxidative Stress, Inflammation, Impaired Angiogenesis and Atherogenesis in Myocardial Infarction in Rats

et al. 2014

View full text Add to dashboard Cite

Purpose: Accumulating evidences suggest a critical role of trace metal dyshemostasis in oxidative stress and cardiac dysfunction after myocardial infarction (MI). This study investigated the cardioprotective effects of selenium yeast (Se), chromium picolinate Cr(pic)3, zinc sulfate (Zn) and their combination on isoproterenol (ISO)-induced MI. Methods: Rats were divided into six groups: normal control, ISO control, Se-pretreated (0.1 mg/kg), Cr(pic)3-pretreated (400 µg/kg), Zn-pretreated (30 mg/kg) and metal combination-pretreated groups. All metals were administered for 28 days and at the 27th day, MI was induced by subcutaneous injection of ISO (85 mg/kg) once for two consecutive days. Results: ISO control group showed hyperlipidemia, elevation of cardiac biomarkers and lipid peroxidation and increased immunostaining of p47 phox NADPH oxidase subunit in addition to decreased levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Cardiac levels of tumor necrosis factor-α (TNF-α) were increased, while vascular endothelial growth factor (VEGF, the major angiogenic factor) was decreased. Pretreatment with Se normalized the cardiac enzymes, lipid peroxidation, GSH, SOD, CAT, GPx, TNF-α and VEGF (P<0.001) and reduced the immunostaining of p47 phox subunit. However, Se failed to correct the dyslipidemia. Cr(pic)3 significantly improved lipid profile (P<0.001) and all other biochemical deviations except for VEGF. Zn, but to lesser extent, reduced the oxidative damage and TNF-α levels and improved both dyslipidemia and angiogenesis. Combination therapy exhibited less prominent protection compared to individual metals. Conclusion: Daily supplementation with trace metals is promising for improving myocardial performance via preventing oxidative damage, induction of angiogenesis, anti-inflammatory and/or anti-hyperlipidemic mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

show abstract

“…DN was considered as a major complication of diabetes in global population (Kelly et al., ) and its development, management, and prevention were regulated by nutrition and diet (Selcuk et al., ). Obesity‐ and/or diabetes‐induced hyperglycemia is the main key factor for the development and progression of DN, which activates the various signaling pathways such as polyol, hexosamine, NF‐kB, AGE, PKC, Bax/Bcl‐2, and other pathways via ROS generation and lead to the insulin resistance associated with renal damage (Haq, Banday, & Bashir, ).…”

Section: Discussionmentioning

confidence: 99%

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Karim

Chanudom

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)induced T2D nephropathy of albino mice. In vitro total phenolic content, 2,2'-azino-bis(3-ethylbenzothiazoline-6sulphonic acid) (ABTS) activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant capacity, and α-amylase inhibition activity as antidiabetic assay of MVR were performed. In vivo mice body weight, oral glucose, and maltose tolerance test, metabolic parameters (plasma glucose, insulin level, omeostasis model assessment-estimated insulin resistance), biochemical parameters (kidney hypertrophy, blood urea nitrogen, creatinine), oxidative stress parameters (malondialdehyde, superoxide dismutase, catalase) were estimated in an intervention study. Additionally, renal morphology and early apoptosis were observed following the H & E staining and TUNEL assay of the tissue frozen section. We found that the aqueous extract of MVR possesses potent in vitro antioxidative and antidiabetic activities. Animal intervention results showed that MVR 100, 200 mg/kgBW, and Glibenclamide 60 mg/kgBW treatments significantly improved (P < 0.05) the abovementioned parameters compared to the diabetic control group. Furthermore, treatments also significantly restored (P < 0.05) kidney histological alterations and reduced cellular apoptosis compared to the diabetic control group. These findings concluded that MVR treatments significantly modulated the glucose intolerance, metabolic alterations, and oxidative stress-induced pathological alterations and cellular apoptosis of diabetic kidney.Practical Application: Garcinia mangostana, a polyphenol rich natural product, is obtained from the tropical rain forest area of Southeast Asian countries and processes diverse biological activities including antioxidant, anti-proliferative, antiinflammatory, anti-carcinogenic, and so on. This research first time focuses on the nephro-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR) from the mangosteen fruit pericarp. Our study provides the efficient data to prove the beneficial effect of MVR as a dietary supplement for the prevention and management of diabetic nephropathy.

show abstract

Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

Cited by 40 publications

References 45 publications

Simultaneous analysis of Cr(III), Cr(VI), and chromium picolinate in foods using capillary electrophoresis‐inductively coupled plasma mass spectrometry

Simultaneous analysis of Cr(III), Cr(VI), and chromium picolinate in foods using capillary electrophoresis‐inductively coupled plasma mass spectrometry

Preventive Effects of Selenium Yeast, Chromium Picolinate, Zinc Sulfate and their Combination on Oxidative Stress, Inflammation, Impaired Angiogenesis and Atherogenesis in Myocardial Infarction in Rats

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Contact Info

Product

Resources

About