Chromium Picolinate Toxicity

Cerulli, Jennifer; Grabe, Darren W.; Gauthier, Isabelle; Malone, Margaret; McGoldrick, Mary

doi:10.1345/aph.17327

Cited by 185 publications

(86 citation statements)

References 10 publications

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“…60,61 Another case of severe renal impairment in a 33-year-old woman was reported. 62 She had self-administered a dose several times higher than the recommended daily allowance. Finally, a 32-year-old man was reported to have ingested 1 mg of chromium picolinate daily for 4 days.…”

Section: Discussionmentioning

confidence: 99%

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

2003

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The aim of this meta-analysis was to assess the evidence of chromium picolinate for reducing body weight. Literature searches were conducted on Medline, Embase, The Cochrane Library, Amed and Ciscom. Nine experts and four manufacturers of commercial preparations containing chromium picolinate were asked to contribute published and unpublished studies. There were no restrictions regarding the language of publication. The screening of studies, selection, data extraction, validation and the assessment of methodological quality were performed independently by two reviewers. To be included, studies were required to state that they were randomized, double-blind and placebo-controlled, and report on body weight. Ten trials met all inclusion criteria and provided data, which were suitable for statistical pooling. For body weight a significant differential effect was found in favour of chromium picolinate (weighted mean difference: À1.1 kg; 95% confidence interval (CI): À1.8 to À0.4 kg, n ¼ 489). Sensitivity analysis suggests that this effect is largely dependent on the results of a single trial (weighted mean difference: À0.9 kg; 95% CI: À2.0 to 0.2 kg, n ¼ 335). Three of the reviewed trials reported on adverse events, indicating their absence in the treatment groups. In conclusion, our meta-analysis suggests a relatively small effect of chromium picolinate compared with placebo for reducing body weight. The clinical relevance of the effect is debatable and the lack of robustness means that the result has to be interpreted with caution.

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Section: Discussionmentioning

confidence: 99%

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

2003

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“…There are three case reports of renal dysfunction secondary to chromium picolinate (CP) (15)(16)(17). The first patient had a 5-mo history of ingesting 1200 to 2400 g/d CP and presented with anemia, hemolysis, thrombocytopenia, hepatic dysfunction, and acute kidney injury (AKI) (15).…”

Section: Chromium Picolinatementioning

confidence: 99%

“…The first patient had a 5-mo history of ingesting 1200 to 2400 g/d CP and presented with anemia, hemolysis, thrombocytopenia, hepatic dysfunction, and acute kidney injury (AKI) (15). Chromium levels were three times normal.…”

Section: Chromium Picolinatementioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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Complementary and alternative medicine (CAM) is a multibillion-dollar industry. Almost half of the American population uses some form of CAM, with many using them in addition to prescription medications. Most patients fail to inform their health care providers of their CAM use, and physicians rarely inquire. Annually, thousands of dietary supplement-induced adverse events are reported to Poison Control Centers nationwide. CAM manufacturers are not responsible for proving safety and efficacy, because the Food and Drug Administration does not regulate them. However, concern exists surrounding the safety of CAM. A literature search using MEDLINE and EMBASE was undertaken to explore the impact of CAM on renal function. English-language studies and case reports were selected for inclusion but were limited to those that consisted of human subjects, both adult and pediatric. This review provides details on dietary supplements that have been associated with renal dysfunction and focuses on 17 dietary supplements that have been associated with direct renal injury, CAM-induced immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, and hepatorenal syndrome. It is concluded that it is imperative that use of dietary supplements be monitored closely in all patients. Health care practitioners must take an active role in identifying patients who are using CAM and provide appropriate patient education.

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“…Hydroxycut, which is a popular weight loss supplement, has been reported to be associated with hepatotoxicity [14]. Chromium, another popular active ingredient, was linked with cases of acute hepatitis, thrombocytopenia and renal failure in a woman with chronic excessive use [15], and with rhabdomyolysis in two cases who used chromium as exercise aid [16,17]. Cassia species were the most frequent ingredient as declared by the evaluated websites within this study.…”

Section: Discussionmentioning

confidence: 83%

Online weight loss supplement market and public health: An analysis of Turkish websites marketing weight loss supplements

Kaplan¹,

Demir²,

Karadaş³

et al. 2012

CMJ

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Aim. The Internet is becoming the primary tool of purchasing weight loss supplements since it is easily accessible to the consumers. When the uncontrollable nature of the Internet and the public's general tendency to use these supplements are considered together, the information conveyed to general audience in such websites become of great importance in the context of public health. This study aimed to analyze the quality and the quantity of the information conveyed to the consumers by Turkish websites marketing weight loss supplements. Method. This study was carried out between June and October, 2009. and a keyword search with the search query strings "weight loss drug" and "herbal weight loss" in Turkish conducted using Google to found websites of first 50 results of each search which were in Turkish and accessible to Turkish people and marketing these products Results. In majority of the websites, the information provided was found to be inadequate and misleading. Conclusion. Raising the public awareness and bringing restrictions of online marketing of these kinds of supplements are the urgent priorities to protect consumers from possible health risks.Keywords: Weight loss supplements, herbal weight loss, internet, online, marketing, safety, public health Özet Amaç. İnternet, zayıflatıcı gıda takviyelerinin temininde öncelikli bir araç haline gelmeye başlamıştır. İnternetin kontrol edilmesi güç yapısı ve halkın bu takviyelere olan ilgisi düşünüldüğünde, zayıflatıcı gıda takviyelerini pazarlayan web sitelerinden tüketiciye iletilen bilginin halk sağlığı açısından ne kadar önemli olduğu anlaşılacaktır. Bu çalışmada, zayıflatıcı gıda takviyelerini pazarlayan Türkçe içerikli internet sitelerindeki bilginin niceliksel ve niteliksel açıdan değerlendirilmesi amaçlanmıştır. Yöntem. Bu çalışma 2009 yılının Haziran ve Ekim ayları arasında Google arama motorunda Türkçe olarak "kilo kaybı ilaç" ve bitkisel kilo kaybı" sözcük dizinleri kullanarak Türk halkının erişebileceği bu ürünleri pazarlayan ilk 50 web sitesinin taranması ile gerçekleştirildi Bulgular. Genel olarak web sitelerinin çoğunluğunun içerdiği bilgilerin yetersiz ve yanıltıcı olduğu gözlenmiştir. Sonuç. Tüketicilerin bu tür takviyelerin neden olabileceği olası sağlık risklerinden korunması için atılması gereken acil ve öncelikli adımlar, tüketici farkındalığının arttırılması ve bu ürünlerin internet üzerinden pazarlanmasına getirilecek kısıtlamalardır.Anahtar sözcükler: Zayıflatıcı gıda takviyeleri, bitkisel ilaç ile zayıflama, internet, pazarlama, güvenlilik, halk sağlığı Geliş tarihi

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Chromium Picolinate Toxicity

Abstract: Chromium supplements may cause serious renal impairment when ingested in excess. Medication histories should include attention to the use of OTC nutritional supplements often regarded as harmless by the public and lay media.

Cited by 185 publications

References 10 publications

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

A Review of Dietary Supplement–Induced Renal Dysfunction

Online weight loss supplement market and public health: An analysis of Turkish websites marketing weight loss supplements

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