Chromoblastomycosis in Nepal: A study of 13 cases

Pradhan, Seema V; Talwar, OP; Ghosh, Arnab; Swami, Ravi; Kc, Shiva Raj; Gupta, Sanjeev Kumar

doi:10.4103/0378-6323.32741

Cited by 42 publications

(37 citation statements)

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“…Development of squamous cell carcinoma had also been reported in the long standing cases (9). The HP of cutaneous Chromoblastomycosis reveals pseudoepitheliomatous hyperplasia, dermal abscess formation, chronic granulomatous inflammation with multinucleated giant cells and diagnostic 'copper penny' bodies (1,2,10). In this case though well defined granuloma was not observed, histiocytes and foreign body giant cells were noted.…”

Section: Discussionmentioning

confidence: 87%

“…subsequently Medlar described the characteristic histological appearance of sclerotic bodies, which thereafter were named as 'Medlar bodies' . Other synonyms are "copper-pennies" or "mauriform" cells (2). Chromoblastomycosis is belong to phaeohypomycosis group and caused by dematiaceous (naturally pigmented) fungi such as Fonsecaea pedrosoi, Phialophora verrucosa, Fonsecaea compactum, Cladophialophora carrionii, exophiala jeanselmei, e. castellanii and Rhinocladiella aquaspersa.…”

Section: Discussionmentioning

confidence: 99%

“…Cases have been documented from several states of India (1)(2)(3)(4)(5). The characteristic lesions are warty papules, verrucous plaques or solid nodules developing in the skin at the site of traumatic implantation of the fungus, usually at an extremity (6).…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

Bandyopadhyay¹,

Majumdar²,

Gangopadhyay³

et al. 2013

TJPATH

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Chromoblastomycosis is a rare chronic fungal infection of skin and subcutaneous tissue. It is primarily a disease of tropical and subtropical regions and affects mainly the agricultural workers following trauma with vegetable matter. Cutaneous Chromoblastomycosis may clinically mimic cutaneous tuberculosis as both the condition usually presents with hyper pigmented verrucous lesion of skin.Here in we report a case of chronic cutaneous Chromoblastomycosis in a middle aged woman from north eastern part of India, who was initially misdiagnosed as tuberculosis verrucosa cutis. In histopathology characteristic brown colored spores of the fungus (also known as copper pennies) were seen within dermal abscess. The organism isolated from culture of the biopsy material was Fonsecaea pedrosoi thus confirming our diagnosis of cutaneous chromoblastomycosis. The patient responded well to oral Itraconazole.The dermatologists and pathologists should be aware of this condition especially when dealing with verrucous lesion of the skin. The pathologists should search for fungal spores in cutaneous lesion with pseudoepitheliomatous hyperplasia and dermal abscess.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

Bandyopadhyay¹,

Majumdar²,

Gangopadhyay³

et al. 2013

TJPATH

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show abstract

“…4 Other unusual sites of involvement are upper extremities, face, penile shaft, vulva, tonsil, pleural cavity, ileocaecal region, laryngotracheal area and ala of nose. [4][5][6] It usually follows a traumatic implantation of the etiologic agent beneath the epidermis and subsequently it spreads to the adjacent skin, thus causing satellite lesions as seen in our case. 5,7 Hematogenous spread is rare, commonly occurs with Cladosporium Trichoides.…”

Section: Case Reportmentioning

confidence: 93%

“…[4][5][6] It usually follows a traumatic implantation of the etiologic agent beneath the epidermis and subsequently it spreads to the adjacent skin, thus causing satellite lesions as seen in our case. 5,7 Hematogenous spread is rare, commonly occurs with Cladosporium Trichoides. 5 The disease commonly occurs in middle-aged males (30-50 years).…”

Section: Case Reportmentioning

confidence: 93%

Chromoblastomycosis: a case report with literature review

2016

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<p class="abstract">Chromoblastomycosis is a chronic progressive cutaneous fungal infection caused by several naturally pigmented fungi that is frequently misdiagnosed clinically because of its polymorphic clinical presentation. We present a case of cutaneous chromoblastomycosis in a 52 year male in the right leg that was mimicking mycetoma/cutaneous tuberculosis clinically. Later, it was diagnosed as chromoblastomycosis in histopathological examination on identification of characteristic sclerotic/medlar bodies. We found combination of chemotherapy and wide local excision was effective in the management of localized chromoblastomycosis with favorable outcome. To conclude, chromoblastomycosis should be considered in the differential diagnosis of chronic cutaneous infections and one has to look for sclerotic bodies particularly in granulomatous lesions as it has specific treatment<span lang="EN-IN">.</span></p>

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Chromoblastomycosis as an endemic disease in temperate Europe: first confirmed case and review of the literature

Pindycka-Piaszczyńska

Krzyściak

Piaszczyński

et al. 2013

Eur J Clin Microbiol Infect Dis

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This study reports a case of a 56-year-old white male, retired coal-miner, diagnosed with chromoblastomycosis lasting 20 years. The infection site was the burnt skin of the back. For many years the patient had not undertaken any treatment believing that the lesion had been a burn scar. A gradual increase in lesion size prompted the patient to start therapy. The diagnosis was made by histopathological examination and mycological culture. Identification of the causative agent at the species level was achieved by sequence analysis of the internal transcribed spacer (ITS) region and D1/D2 domains of the 26S rDNA. To our knowledge, this is the first documented case of chromoblastomycosis caused by Fonsecaea monophora in temperate Europe, outside the endemic area for the disease. This finding is highly significant for understanding the routes of infection of chromoblastomycosis and radically revises the traditional view of the natural ecology of the etiological agents of the disease.

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Chromoblastomycosis in Nepal: A study of 13 cases

Abstract: Farming is the commonest occupation in patients with chromoblastomycosis. Early histological diagnosis helps in effective management of the condition.

Cited by 42 publications

References 0 publications

Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

Chromoblastomycosis: a case report with literature review

Chromoblastomycosis as an endemic disease in temperate Europe: first confirmed case and review of the literature

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