Chromoblastomycosis with malignant transformation and cutaneous-synovial secondary localization. The potential therapeutic role of itraconazole

Paul, C.; Dupont, B.; Pialoux, G.; Avril, Marion; Pradinaud, R.

doi:10.1080/02681219180000471

Cited by 14 publications

(4 citation statements)

References 7 publications

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“…The latter is the most aggressive and disabling CBM-associated complication, leading mostly to squamous cell carcinoma (255)(256)(257)(258)(259). Recently, Azevedo et al reported seven cases from Brazil and reviewed another 10 reported cases (259).…”

Section: Complications and Sequelaementioning

confidence: 99%

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Chromoblastomycosis

et al. 2017

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SUMMARY Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

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Section: Complications and Sequelaementioning

confidence: 99%

“…In advanced cases, chronic lymphedema, ankylosis, and malignant transformation are observed (13,15,246,(255)(256)(257)(258)(259). The latter is the most aggressive and disabling CBM-associated complication, leading mostly to squamous cell carcinoma (255)(256)(257)(258)(259).…”

Section: Complications and Sequelaementioning

confidence: 99%

Chromoblastomycosis

et al. 2017

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“…eleven years [9]. Subsequently, around 23 cases of tumors derived from CBM were documented worldwide (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20]. The sex ratio was 19/2.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of nasal chromoblastomycosis degenerating into squamous cell carcinoma from a nonendemic region

Frioui¹,

Jaber²,

Mtibaa³

2021

Our Dermatol Online

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Chromoblastomycosis (CBM) is a granulomatous mycosis rarely described outside tropical countries. Degeneration into squamous cell carcinoma (SCC) is its most serious complication. We report the first case of nasal CBM degenerating into SCC. In 2006, a sixty-year-old male presented himself with an infiltrated plaque on the right thigh. The diagnosis of CBM was confirmed by the presence of fungal elements. In 2019, the patient had developed a mass coming from the right nasal cavity. It had rapidly involved the nasal dorsum. An ulcer-budding nasal tumor and an elevated erythematous and verrucous plaque on the thigh were noted. A biopsy revealed a granulomatous dermis with fungal elements. Other nasal biopsy fragments showed differentiated SCC. A fungal culture inoculated with tissue from both lesions showed dark colonies. The diagnosis of nasal CBM with SCC degeneration was reached. The patient presented asymptomatic endonasal CBM that had slowly evolved and recently degenerated.

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“…Complications in advanced cases include scars, lymphoedema, elephantiasis and fibrosis 6 . Squamous cell carcinoma has been reported to complicate extensive long‐standing lesions 7 …”

Section: To the Editormentioning

confidence: 99%