Chromomycosis: casuistics of the Dermatology Service of the National Hospital, period 1991- 2015

Wattiez, Víctor; García, Jesús; Aquino, Nidia; Insaurralde, Sonia; Mendoza, Gloria; Celías, Luís; Rivelli, Victoria; Gorostiaga, Graciela; Aldama, Arnaldo

doi:10.18004/rvspmi/2312-3893/2017.04(02)27-033

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…Only 8% of the patients had mycological studies performed, results that coincide with the study by García et al (2022) [8] and Wattiez et al (2017) [13], in which the highest proportion of diagnoses of the disease is in the Anatomic…”

Section: Discussionsupporting

confidence: 84%

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

Dianiley García Gómez,

Ricardo Osés Rodríguez,

Daniel Artiles Martínez

et al. 2023

ABJAR

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In Villa Clara province, Cuba, microorganisms and climatic conditions coexist for the development of the infectious entity chromoblastomycosis. Besides, there is a high percentage of agricultural and handicraft workers exposed to acquiring this infection. The objective of the research consisted in describing the etiological diagnosis and correlating chromoblastomycosis with average climatic variables of the meteorological stations located in Villa Clara. Between 2018-2022, a descriptive, cross-sectional study was conducted in a population of 25 patients diagnosed with chromoblastomycosis by anatomopathological and microbiological studies. Absolute frequencies were used as a summary measure, and for correlation with climatic data from the five meteorological stations, inferential statistics. Of the total number of patients, 92% were diagnosed by anatomopathological studies and only 2/8% had mycological studies, in which the species Fonsecaea pedrosoi was isolated. There was a significant correlation between mean temperature (p=0.045) and mean predicted wind (p=0.028) and the number of cases. This was not the case with relative air humidity (p>0.05). It is concluded that in Villa Clara province, only the etiological agent F. pedrosoi was the cause of the disease during the period studied, with a significant relationship between the disease and the average climatic variables mean temperature and mean predicted wind.

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Section: Discussionsupporting

confidence: 84%

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

Dianiley García Gómez,

Ricardo Osés Rodríguez,

Daniel Artiles Martínez

et al. 2023

ABJAR

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“…A total of 51 articles described 2,619 patients that were reported in Venezuela (1,167 cases) [ 43 – 49 ], Brazil (1,143 cases) [ 50 – 70 ], Colombia (167 cases) [ 71 – 76 ], Paraguay (82 cases) [ 77 – 81 ], Ecuador (34 cases) [ 82 , 83 ], French Guiana (11 cases) [ 84 – 86 ], Peru (7 cases) [ 87 – 89 ], Argentina (4 cases) [ 90 , 91 ], Bolivia (3 cases) [ 92 ], and Uruguay (1 case) [ 93 ]. In Brazil, most cases came from the Amazon region (states of Pará, Rondonia, and Amazon), Maranhão state (northeast region), in addition to the Central-West Region (Mato Grosso) and South Regions (states of Paraná and Rio Grande do Sul) [ 50 – 54 , 56 – 58 , 62 , 68 – 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…(82; 9.5%). The latter agent is typical of semi-arid rural areas of Venezuela and has been found sporadically in Brazil, Paraguay, Ecuador, and Peru [ 43 – 46 , 48 , 49 , 60 , 63 , 77 , 83 , 89 ]. The report by Richard-Yegres and Yegres accounted for 900 cases of CBM in Venezuela, with 490 (54.5%) in the state of Falcón, caused almost exclusively by C .…”

Section: Resultsmentioning

confidence: 99%

“…Surgical debridement as adjuvant therapy was described in additional 191 cases [ 35 , 37 , 39 , 47 , 50 , 100 , 110 , 113 , 165 , 170 , 182 , 204 , 212 ]. Itraconazole was the antifungal therapy mostly used in all continents, being reported in 318 patients, followed by treatment with terbinafine that was used by 87 patients, especially in India, China, and Madagascar [ 18 , 65 , 67 , 68 , 70 , 77 , 99 , 165 , 170 ]. The use of fluconazole, ketoconazole, flucytosine, and systemic or intralesional amphotericin were only sporadically reported.…”

Section: Resultsmentioning

confidence: 99%

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The global burden of chromoblastomycosis

et al. 2021

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Background Chromoblastomycosis (CBM), represents one of the primary implantation mycoses caused by melanized fungi widely found in nature. It is characterized as a Neglected Tropical Disease (NTD) and mainly affects populations living in poverty with significant morbidity, including stigma and discrimination. Methods and findings In order to estimate the global burden of CBM, we retrospectively reviewed the published literature from 1914 to 2020. Over the 106-year period, a total of 7,740 patients with CBM were identified on all continents except Antarctica. Most of the cases were reported from South America (2,619 cases), followed by Africa (1,875 cases), Central America and Mexico (1,628 cases), Asia (1,390 cases), Oceania (168 cases), Europe (35 cases), and USA and Canada (25 cases). We described 4,022 (81.7%) male and 896 (18.3%) female patients, with the median age of 52.5 years. The average time between the onset of the first lesion and CBM diagnosis was 9.2 years (range between 1 month to 50 years). The main sites involved were the lower limbs (56.7%), followed by the upper limbs (19.9%), head and neck (2.9%), and trunk (2.4%). Itching and pain were reported by 21.5% and 11%, respectively. Malignant transformation was described in 22 cases. A total of 3,817 fungal isolates were cultured, being 3,089 (80.9%) Fonsecaea spp., 552 (14.5%) Cladophialophora spp., and 56 Phialophora spp. (1.5%). Conclusions and significance This review represents our current knowledge on the burden of CBM world-wide. The global incidence remains unclear and local epidemiological studies are required to improve these data, especially in Africa, Asia, and Latin America. The recognition of CBM as NTD emphasizes the need for public health efforts to promote support for all local governments interested in developing specific policies and actions for preventing, diagnosing and assisting patients.

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“…The lesions mainly described were of the verrucous type, coinciding with studies published in Brazil and other countries. 7 , 11 , 15 , 17 , 18 , 21 , 52 , 54 , 57 , 64 , 66 , 71 , 72 , 73 , 74 Nevertheless, patients with chromoblastomycosis of chronic evolution may present different types of lesions simultaneously. 7 …”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology and clinical‐laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil

Guevara

Nery

Melhem

et al. 2022

Mycoses

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Introduction Chromoblastomycosis is a disease caused by melanized fungi, primarily belonging to the genera Fonsecaea and Cladophialophora, mainly affecting individuals who are occupationally exposed to soil and plant products. This research aimed to determine the clinical, epidemiological and laboratory characteristics of chromoblastomycosis in the state of Mato Grosso, Brazil. Materials and Methods Patients diagnosed with chromoblastomycosis treated at the Júlio Müller University Hospital, Cuiabá, Brazil, from January 2015 to December 2020, whose isolates were preserved in the Research Laboratory of the Faculty of Medicine of the Federal University of Mato Grosso. Isolates were identified by partly sequencing the Internal Transcribed Spacer (ITS) and β‐tubulin (BT2) loci. AFLP fingerprinting was used to explore the genetic diversity. Susceptibility to itraconazole, voriconazole, 5‐fluorocytosine, terbinafine and amphotericin B was determined by the broth microdilution technique. Results Ten patients were included, nine were male (mean age = 64.1 years). Mean disease duration was 8.6 years. Lesions were mainly observed in the lower limbs. Predominant clinical forms were verrucous and scarring. Systemic arterial hypertension and type II diabetes mellitus were the predominant comorbidities. Leprosy was the main concomitant infectious disease. Fonsecaea pedrosoi was the unique aetiological agent identified with moderate genetic diversity (H = 0.3934–0.4527; PIC = 0.3160–0.3502). Antifungal agents with the highest activity were terbinafine, voriconazole and itraconazole. Conclusion Chromoblastomycosis is affecting the poor population in rural and urban areas, mainly related to agricultural activities, with F. pedrosoi being the dominant aetiologic agent. All isolates had low MICs for itraconazole, voriconazole and terbinafine, confirming their importance as therapeutic alternatives for chromoblastomycosis.

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Chromomycosis: casuistics of the Dermatology Service of the National Hospital, period 1991- 2015

Cited by 4 publications

References 2 publications

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

The global burden of chromoblastomycosis

Molecular epidemiology and clinical‐laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil

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