“…There are many classical and new synthetic protocols available for accessing such important chromone moieties with diverse functionalization possibilities. ,,− Particularly, for the synthesis of the important chromone-2-carboxylate scaffold, some interesting methods are available, such as Kostanecki–Robinson, Baker–Venkatraman, Ruhemann, Baker–Ollis, and Simon reactions along with few other methods (Scheme a,b). , Also, chromone-2-carboxylic acid scaffold is prepared by modifying other chromone-4-one moieties using various harsh synthetic modifications. ,,− Among them, Kostanecki–Robinson/Baker–Venkatraman reactions, , which use 2-hydroxyacetophenone ( 9 ) as the starting material (Scheme a), are the most reliable and preferred protocols by medicinal chemists as there will not be any regioisomer possibility, as carbonyl and phenoxy groups are pre-fixed in the starting material itself ( 9 ). ,, Ruhemann and other related reactions, which use phenols ( 12 ) as the starting materials, are not preferred because in these reactions, cyclization proceeds on the either side of phenoxy group of intermediate 13 (in case of unsymmetrical phenols) causing regioselectivity issue (Scheme b). , Moreover, these reactions generally need high temperatures (often exceeding 140 °C) for cyclization to occur, although some successful attempts have been made to develop milder reaction conditions. , This could be the probable reason why our careful literature survey revealed that the majority of the reported medicinal chemistry work on the development of biologically active new chromone-2-carboxylic acid derivatives primarily used the two-step Kostanecki–Robinson reaction approach starting from 2-hydroxyacetophenone (Scheme a), ,,− even though it restricts the choice of raw materials to only “2-hydroxyacetophenone” and also requires the use of harsh acidic conditions for cyclization to occur.…”