Chromone and isocoumarin derivatives from the endophytic fungus <i>Xylomelasma</i> sp. Samif07, and their antibacterial and antioxidant activities

Lai, Daowan; Li, Jing; Zhao, Siji; Gu, Gan; Gong, Xiao Yang; Proksch, Peter; Zhou, Ligang

doi:10.1080/14786419.2019.1696333

Cited by 23 publications

(10 citation statements)

References 14 publications

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“…Meanwhile, chlorogenic acid was found to have antibacterial activity against Foodborne Pathogen Pseudomonas aeruginosa and Salmonella enteritidis (41), and caffeic acid was found to have antibacterial activity against Staphylococcus aureus clinical strains (42). In addition, the antibacterial effect of Salvia miltiorrhiza Bunge (Danshen), a major component herb of HQT, has been widely reported and studied (43)(44)(45). Therefore, we speculate that HQT can significantly restore and improve gut microbial species and function in RA patients, possibly due to the fact that HQT contains a variety of compounds with antimicrobial effects.…”

Section: Discussionmentioning

confidence: 99%

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

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Several studies have investigated the causative role of the microbiome in the development of rheumatoid arthritis (RA), but changes in the gut microbiome in RA patients during drug treatment have been less well studied. Here, we tracked the longitudinal changes in gut bacteria in 22 RA patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX. There were differences in the gut microbiome between untreated (at baseline) RA patients and healthy controls, with 37 species being more abundant in the RA patients and 21 species (including Clostridium celatum) being less abundant. Regarding the functional analysis, vitamin K2 biosynthesis was associated with RA-enriched bacteria. Additionally, in RA patients, alterations in gut microbial species appeared to be associated with RA-related clinical indicators through changing various gut microbiome functional pathways. The clinical efficacy of the two treatments was further observed to be similar, but the response trends of RA-related clinical indices in the two treatment groups differed. For example, HQT treatment affected the erythrocyte sedimentation rate (ESR), while LEF treatment affected the C-reactive protein (CRP) level. Further, 11 species and 9 metabolic pathways significantly changed over time in the HQT group (including C. celatum, which increased), while only 4 species and 2 metabolic pathways significantly changed over time in the LEF group. In summary, we studied the alterations in the gut microbiome of RA patients being treated with HQT or LEF. The results provide useful information on the role of the gut microbiota in the pathogenesis of RA, and they also provide potentially effective directions for developing new RA treatments.

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Section: Discussionmentioning

confidence: 99%

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

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“…Compounds 117 and 29 showed inhibition against only E. carotovora (MIC, 100 µg/mL), and B. subtilis (MIC, 50 µg/mL), respectively. Compounds 118, 119, 29 were found active against S. haemolyticus and E. carotovora (MIC of 75 µg/mL), whereas compound 121 exhibited stronger inhibition against B. subtilis, A. tumefaciens, and X. vesicatoria, with MICs of 25, 75, and 25 µg/mL, respectively [71].…”

Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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“…In addition, they were examined for their antioxidant activity, using hydroxyl radical-scavenging activity test and ascorbic acid as a positive control as well as the Fe 3+ reducing activity method using BHT as a positive control, 121 displayed signicant hydroxyl radical-scavenging and Fe 3+ reducing activity, but 349 showed weak Fe 3+ reducing activity. 164 3.16.4. Unidentied fungal strain 3.16.4.1.…”

Section: Chemistry and Pharmacological Potentials Of Isocoumarins Iso...mentioning

confidence: 99%