Chromophobe Cell Renal Carcinoma in Childhood

Fujii, Yasuhisa; Kihara, Kazunori; Tsujii, Toshihiko; Kawakami, Satoru; Nemoto, Tetsuo; Washizuka, Makoto; Oshima, Hiroyuki

doi:10.1111/j.1442-2042.1998.tb00246.x

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…We reviewed the literature and found only 5 cases of chromophobe RCC in childhood (Table 1) [2,[10][11][12][13]. In the current case, the patient age and tumor grade were in agreement with those of the previous reports.…”

Section: Discussionsupporting

confidence: 89%

A case of chromophobe renal cell carcinoma in a 12-year-old girl

et al. 2015

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Renal cell carcinoma (RCC) accounts for only 2-6 % of pediatric renal tumors. Chromophobe RCC is very rare in pediatric patients, with only a few cases reported. A 12-year-old girl who had abdominal and left flank pain visited the pediatric clinic of a local hospital. A uniformly enhanced tumor measuring 2.5 cm 9 2.3 cm was found on computed tomography. On magnetic resonance imaging, T2-weighted images showed a solid tumor with hyperintensity suggesting intratumoral necrosis. We considered RCC and Wilms' tumor as differential diagnoses, but we could not reach a definitive diagnosis from the radiographic findings. We then performed right partial nephrectomy with regional lymph node dissection. The histopathological diagnosis was pT1aN0 chromophobe RCC. After the surgery, no recurrence has been observed for 15 months.

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Section: Discussionsupporting

confidence: 89%

A case of chromophobe renal cell carcinoma in a 12-year-old girl

et al. 2015

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“…We included 243 cases of pediatric RCC in the analysis of stage‐specific outcomes. Stage I was the most frequent presentation, followed closely by Stage IV and Stage III disease 12–14, 17, 18, 21–56. The stage‐specific overall survival rates were > 90%, > 80%, > 70%, and < 15% for Stages I–IV, respectively (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma

Geller

Dome

2004

Cancer

149

166

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BACKGROUND Local lymph node involvement in adults with renal cell carcinoma (RCC) is associated with poor outcome. The prognostic significance of local lymph node involvement in children with RCC has not been studied systematically. METHODS A retrospective review of patients treated at St Jude Children's Research Hospital (Memphis, TN) and an extensive review of the medical literature were undertaken to evaluate the prognostic significance of local lymph node involvement in pediatric RCC. RESULTS Thirteen patients with the diagnosis of RCC were treated at St. Jude since the hospital's inception in 1962. Four patients presented with lymph node‐positive, distant metastasis‐negative (N+M0) disease, and all 4 remain disease free after resection without adjuvant therapy (follow‐up duration, 2–9 years). A systematic review of the literature including 243 pediatric patients with RCC revealed stage‐specific survival rates of 92.5%, 84.6%, 72.7%, and 12.7% for Stage I–IV disease, respectively. Of 58 children with N+M0 RCC for whom outcome data were available, 42 (72.4%) were alive without disease at last follow‐up. Among patients whose therapy could be discerned, those who received no adjuvant therapy fared as well (15 of 16 alive) as those who received various adjuvant treatments (22 of 31 alive). CONCLUSIONS Children with lymph node–positive RCC in the absence of distant metastatic disease had a relatively favorable long‐term prognosis, with survival rate nearly triple those of adult historical controls. Until highly effective therapies for RCC are identified, these children should not be exposed to adjuvant treatment. Further investigation of the biologic differences between adult and pediatric RCC is warranted. Cancer 2004. © 2004 American Cancer Society.

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“…Only 1 other CRCC was identified in a child upon review of the National Wilms Tumor Study after their pathologists reviewed the case presented here (E. Perlman, personal communication). Seven other CRCCs have been reported in prior retrospective series of RCCs in children or case reports published between 1998 and 2005 (Table 1) [2][3][4][5][6][7]. No more than 2 CRCCs were reported in any of the series, although Bruder and others identified 2 patients with RCC, one with tuberous sclerosis that had chromophobe-like features with unconvincing Hale's colloidal iron stains [6].…”

Section: Discussionmentioning

confidence: 99%

“…In this report, we present a chromophobe RCC (CRCC), a form of RCC heretofore rarely described in children in the literature. Prior to this case, 7 cases of CRCC have been described in 2 case reports and 4 series of RCCs in children [2][3][4][5][6][7]. Although these tumors can be confused with other eosinophilic renal epithelial neoplasms, they feature a characteristic histomorphology, both by light microscopy and electron microscopy; cytoplasmic staining with Hale's colloidal iron; and an absence of the 3p deletion that is seen in many nonpapillary RCCs.…”

Section: Introductionmentioning

confidence: 99%

Chromophobe Renal Cell Carcinoma in a Child: Case Report and Review of the Literature

Katzman

Schwartz

2007

Pediatr Dev Pathol

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Renal cell carcinomas are rare in children but are in the differential diagnosis of renal masses in children age 5 years and older. We present a case of a chromophobe renal cell carcinoma in an 8-year-old boy that arose as a 7-cm (greatest dimension) unilateral renal mass. The tumor had eosinophilic cells, with the typical perinuclear halos and positive staining with Hale's colloidal iron that are seen in this tumor. Although papillary renal cell carcinomas are the most common variant of renal cell carcinoma in children, chromophobe renal cell carcinoma is a rarely reported variant that is not uncommon and has a relatively favorable prognosis in adults.

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Chromophobe Cell Renal Carcinoma in Childhood

Abstract: Wereportthefirstcaseofchromophobecell renal carcinoma in chi1dhood.A 12-year-old boy presented gross hematuria following minor trauma. He was diagnosed as having a left renal tumor 45-mm in diameter. Radical nephrectomy was performed. One year later the boy was well.Int J Urol 1998;5:92-93

Cited by 7 publications

References 7 publications

A case of chromophobe renal cell carcinoma in a 12-year-old girl

A case of chromophobe renal cell carcinoma in a 12-year-old girl

Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma

Chromophobe Renal Cell Carcinoma in a Child: Case Report and Review of the Literature

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