Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, and array comparative genomic hybridization analysis of 18 cases and review of the literature

Pecková, Květoslava; Martínek, Petr; Ohe, Chisato; Bulimbašić, Stela; Condom, Enric; Montiel, Delia Pérez; López, José I.; Daum, Ondřej; Rotterová, Pavla; Kokošková, Bohuslava; Dubova, Magdalena; Pivovarčíková, Kristýna; Bauleth, Kevin; Grossmann, P.; Hora, Milan; Kalusová, Kristýna; Davidson, Whitney; Slouka, David; Miroslav, Sulc; Buzrla, Petr; Mírka, Hynek; Michal, Michal; Hes, Ondřej

doi:10.1016/j.anndiagpath.2015.05.001

Cited by 29 publications

(29 citation statements)

References 24 publications

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“…Mokhtar et al reported a ChRCC with neuroendocrine differentiation metastatic to a peri-hilar lymph node, the metastasis composed exclusively of the neuroendocrine component [3]. Two of four cases from Peckova's series had distant metastases [5]. Our patient developed lung and mediastinal nodal metastases 3 years after radical nephrectomy, which suggests that RCC with neuroendocrine differentiation is an aggressive tumor.…”

Section: Discussionmentioning

confidence: 66%

“…Peckova et al presented 18 ChRCCs with morphologic features suggestive of neuroendocrine differentiation. Four were confirmed by IHC [5]. Jung et al reported 2 cases of MTSCC positive for chromogranin and synaptophysin [13].…”

Section: Discussionmentioning

confidence: 99%

“…Renal cell carcinoma (RCC) with neuroendocrine differentiation has been rarely reported. Chromophobe renal cell carcinoma (ChRCC) with neuroendocrine differentiation and/or a neuroendocrine-like pattern has been described and characterized [2–5]. Rare cases of PRCC are reported showing positivity for neuroendocrine markers [6].…”

Section: Introductionmentioning

confidence: 99%

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Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma

Wang¹,

Ren²,

Tucker³

et al. 2018

Case Reports in Pathology

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A unique case of combined papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSCC) presenting in a man aged 67 years is reported. The two separate components were distinct on morphological, immunohistochemical (IHC), and genetic grounds, while type 2 PRCC predominated. Three years after the initial diagnosis, the PRCC component metastasized to the lungs where it morphologically mimicked a pulmonary neuroendocrine tumor. Retrospectively focal neuroendocrine differentiation was demonstrated by IHC in the PRCC component of the primary neoplasm.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma

Wang¹,

Ren²,

Tucker³

et al. 2018

Case Reports in Pathology

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“…Molecular-genetic testing will not be required to make a diagnosis of typical chromophobe RCC (ChRCC) (classic or eosinophilic variants). In addition to classic and eosinophilic ChRCCs, there are several other variants which have been described in the literature including pigmented microcystic adenomatoid, multicystic variant, [48][49][50][51] ChRCC with neuroendocrine differentiation, [52][53][54][55][56] and renal oncocytoma-like variant [57]. With the exception of ChRCC with neuroendocrine features, it seems that such variability has no influence on biological behavior.…”

Section: Chromophobe Renal Cell Carcinoma (Chrcc)mentioning

confidence: 99%

“…With the exception of ChRCC with neuroendocrine features, it seems that such variability has no influence on biological behavior. However, ChRCC with neuroendocrine features is a more aggressive variant [52].…”

Section: Chromophobe Renal Cell Carcinoma (Chrcc)mentioning

confidence: 99%

Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach

Alaghehbandan

Montiel

Luís

et al. 2019

Cancers

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Renal epithelial cell tumors are composed of a heterogeneous group of tumors with variable morphologic, immunohistochemical, and molecular features. A "histo-molecular" approach is now an integral part of defining renal tumors, aiming to be clinically and therapeutically pertinent. Most renal epithelial tumors including the new and emerging entities have distinct molecular and genetic features which can be detected using various methods. Most renal epithelial tumors can be diagnosed easily based on pure histologic findings with or without immunohistochemical examination. Furthermore, molecular-genetic testing can be utilized to assist in arriving at an accurate diagnosis. In this review, we presented the most current knowledge concerning molecular-genetic aspects of renal epithelial neoplasms, which potentially can be used in daily diagnostic practice.

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