Chromophobe renal cell carcinoma with extensive calcification and ossification

Wu, Sang Ling; Fishman, Irving J.; Shannon, Rhonda L.

doi:10.1053/adpa.2002.34731

Cited by 20 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, irregular calcifications were present in almost 50% of cases in a large series of 100 CRCCs [30]. Extensive calcification and ossification was noted in one of our cases, similar to a case described previously in 2002 [50]. We hypothesize that all these calcifications, pigmentation and adenomatous to (micro)cystic changes in our cases are probably consequences of microhemorrhages and necroses.…”

Section: Discussionsupporting

confidence: 85%

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Hes

Vaněček

Montiel³

et al. 2005

Virchows Arch

View full text Add to dashboard Cite

We present clinical, morphological, immunohistochemical, ultrastructural and molecular genetic features of 20 cases of a peculiar form of chromophobe renal cell carcinoma (CRCC) with morphology differing from that of conventional CRCC. Microscopically, the typical features of the tumors were microcystic arrangement and formation of adenomatous structures. Microcystic areas were composed of smaller eosinophilic and bigger pale cells having cytological appearance typical of conventional CRCC. Cytological features of the adenomatous structures were mostly different from those of conventional CRCC. They had a typical columnar arrangement with nuclei positioned at the base of the glandular structures and a small amount of a deeply eosinophilic cytoplasm often endowed with brush border facing the lumen of the glands. In addition, all the tumors showed a brown pigmentation. The pigmentation was located mostly extracellularly, where it formed pools of heavy deposits. Microscopic calcifications present in all cases formed psammoma bodies or else the calcifications were more extensive and amorphous in shape. Ultrastructurally, the cells showed features characteristic of CRCC: typical cytoplasmic vesicles were 100-700 nm in size and mitochondria had tubulovesicular, lamellar or circular cristae. Some tumor cells contained dark, variously sized electron-dense pigment granules. Neither melanosomes nor membrane-bound neurosecretory granules were seen. Using fluorescence in-situ hybridization probes for chromosomes 1, 2, 6, 10, 13, 17 and 21, the tumors revealed massive loss of tested chromosomes typical for conventional CRCC. Monosomy of chromosomes 1, 2, 6, 10, 13 and 21 was found in 100, 36, 91, 82, 82, 82 and 64% of cases, respectively. None of the cases showed mutation of exons 9, 11, 13 and 17 of the c-kit gene. The important feature of pigmented microcystic chromophobe renal cell carcinoma is a relatively benign biological behavior and the absence of distant metastases and sarcomatoid transformation.

show abstract

Section: Discussionsupporting

confidence: 85%

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Hes

Vaněček

Montiel³

et al. 2005

Virchows Arch

View full text Add to dashboard Cite

show abstract

“…Although calcification is known to occur in RCCs, reports of extensive ossification in CRCC are rare, with only two reports to date. [78] The ossification was present in the fibrous stroma in all the cases. The histogenesis is considered to be from stromal osseous metaplasia.…”

Section: Discussionmentioning

confidence: 93%

Chromophobe renal cell carcinoma: A report of two cases with unusual histological features

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Subsequently, Charles et al described the association of renal squamous carcinoma and cystic renal cell carcinoma [ 3 ] and renal pelvis squamous cell carcinoma with renal cell carcinoma in a tuberculous kidney [ 4 ]. Likewise has been reported association of renal cell carcinoma with another renal cell neoplasms (conventional renal cell carcinoma, oncocytoma, collecting duct carcinoma) and cases with sarcomatoid transformation [ 5 , 6 ] or extensive calcification with ossification [ 7 ]. More recently also has been described one case with focal papillary growth pattern, basaloid features of the nuclear arrangement and stromal osseous metaplasia containing fatty bone marrow elements [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Chromophobe renal cell carcinoma and squamous renal cell carcinoma

et al. 2007

View full text Add to dashboard Cite

Chromophobe renal cell carcinoma (CHRC) is a neoplasm of the kidney with clinicopathologic peculiarities that seems to be of better prognosis than conventional renal cell carcinoma. Classical and eosinophilic types are the two histological variants recorded. Also, it has been described in association with carcinoma of collecting ducts, conventional renal cell carcinoma and sarcomatoid renal cell carcinoma. Squamous renal carcinoma is a very rare neoplasm with a malignant course. We describe a case of simultaneous chromophobe renal cell carcinoma with squamous cell carcinoma, finding which, to the best of our knowledge, has not previously been reported.

show abstract

Chromophobe renal cell carcinoma with extensive calcification and ossification

Cited by 20 publications

References 14 publications

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Chromophobe renal cell carcinoma: A report of two cases with unusual histological features

Simultaneous Chromophobe renal cell carcinoma and squamous renal cell carcinoma

Contact Info

Product

Resources

About