Chromophore appended DPA-based copper(ii) complexes with a diimine motif towards DNA binding and fragmentation studies

Abstract

Two mixed ligand copper(ii) complexes were synthesised and structurally characterised, showing promising results towards DNA binding and fragmentation studies.

Triazine-based mononuclear copper(ii) cis-dichloro and dibromo complexes as functional biomimetic model systems for phenoxazinone synthase and catecholase activities

“…59 The sharp peak observed at −0.315 V is because of copper deposition at the surface of the working electrode. 60 Also, there was an irreversible Cu II /Cu I redox wave observed at a potential of 0.020 V, and another redox process at a negative potential of −0.256 V can be assigned as a successive one-electron metal-based Cu I /Cu 0 reduction process. Other one irreversible peak at −1.136 V and two quasi reversible redox events at −1.392 V and −1.724 V could be assigned to ligand ( L )-based reductions (Table 3).…”

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

“…60 The distance between the copper and nitrogen centers are ∼1.9–2.1 Å. Pentacoordinated copper complexes have shown similar bond lengths to the metal center with the Cu–N bonds varying within 1.96 Å to 2.37 Å. 34,48,61–63 Polyhedral views and the packing along the b -axis are given in Fig. S11–S13 †…”

“…23 In this regard, a large number of copper complexes have been reported with various coordinating ligands and structures. 24–34 In most cases, the selectivity can be improved, and the coordinated ligands have been tuned with a common intercalator and/or fluorophore. A slight modification in the geometry could alter the affinity to a considerable extent, and specificity can be obtained in DNA binding modes.…”

Tailored design, synthesis, and catalytic aspects of mononuclear cis-dichloro copper(ii) complexes with simple DPA-derived tridentate ligands and their biomimicking activities

“…Pentacoordinated systems with DPA-derived ligands have shown similar bond lengths to the metal center with Cu–N bonds varying from 1.96 Å to 2.37 Å and Cu–Cl bonds with ∼2.2–2.3 Å. 51–53 Even for a hexacoordinated system with ClO 4 − occupying the sixth position, the bond distances are comparable. 54…”