Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study

Lv, Shuhua; Niu, Yun; Li, Wei; Liu, Qingjie; Wang, Xiaowei; Chen, Yan

doi:10.1007/s10549-007-9876-1

Cited by 36 publications

(23 citation statements)

References 22 publications

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“…This suggests that a classification of phyllodes tumors of the breast into two categories (benign and malignant) better reflects the genetic reality. Lv et al also confirmed that molecular CGH features of borderline and malignant PTs were similar [15]. They used CGH to identify chromosomal aberrations in 36 cases of benign, borderline, or malignant PTs of the breast.…”

Section: Discussionmentioning

confidence: 85%

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Borderline and malignant phyllodes tumors display similar promoter methylation profiles

et al. 2009

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Mammary phyllodes tumors (PTs) are uncommon fibroepithelial neoplasms. On the basis of histologic criteria, PTs can be divided into benign, borderline, and malignant groups; however, the histologic distinction of PTs is often difficult and arbitrary. In breast cancer, promoter hypermethylation is a common phenomenon, but there are no data available concerning methylation status in PTs. The aim of this study was to assess whether the methylation profiles support the classification of PTs into three subgroups. A multiplex, nested, methylation-specific polymerase chain reaction approach was used to examine promoter methylation of five genes (GSTP1, HIN-1, RAR-beta, RASSF1A, and Twist) in 87 PTs (54 benign, 23 borderline, and 10 malignant). Immunohistochemical staining for GSTP1 was performed using tissue microarray blocks to determine whether GSTP1 promoter hypermethylation correlated with loss of GSTP1 expression. There was a trend of increasing methylation frequency with increasing grade of PTs. The methylation frequency of all genes and the mean number of methylated genes in borderline and malignant PTs were higher than those in benign PTs; however, there were no statistically significant differences between borderline and malignant PTs. GSTP1 promoter hypermethylation was associated with loss of GSTP1 expression (p < 0.001). These results suggest that PTs segregate into only two groups on the basis of their methylation profiles: the benign group and the combined borderline/malignant group.

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Section: Discussionmentioning

confidence: 85%

“…Most recent studies of PTs have concentrated on the genetic changes detected in the tumors [13][14][15]. On the basis of patterns of chromosomal changes by comparative genomic hybridization (CGH), Laé et al classified PTs into two categories (benign and malignant) instead of three categories [13].…”

Section: Introductionmentioning

confidence: 99%

Borderline and malignant phyllodes tumors display similar promoter methylation profiles

et al. 2009

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“…Similar chromosomal changes were identified by Jones et al 46 in their array-GCH analysis in 126 PTs. We must note, however, that Lv et al 47 found the gain of 1q did not correlate with grades, and Lu et al 48 reported that 1q gain was found mainly in benign PTs (6 of 12; 50%), underscoring the need for more conclusive investigations. Loss of 13q in PT suggests that the RB1 gene localized in these regions could be relevant to PT oncogenesis or progression.…”

Section: Molecular/genetic Featuresmentioning

confidence: 84%

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates

Zhang

Kleer

2016

Archives of Pathology &Amp; Laboratory Medicine

211

204

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Context.-Phyllodes tumor (PT) of the breast is a rare fibroepithelial neoplasm with risks of local recurrence and uncommon metastases. The classification proposed by the World Health Organization for PTs into benign, borderline, and malignant is based on a combination of several histologic features. The differential diagnosis between PT and fibroadenoma and the histologic grading of PT remain challenging. In addition, the molecular pathogenesis of PT is largely unknown.Objective.-To provide an updated overview of pathologic features, diagnostic terminology, and molecular alterations of PT.Data Sources.-Current English literature related to PT of the breast.Conclusions.-Phyllodes tumor shows a wide spectrum of morphology. There are no clearly distinct boundaries between PT and fibroadenoma. Strict histologic assessment of a combination of histologic features with classification can help to achieve the correct diagnosis and provide useful clinical information. The genomic landscapes of PT generated from genomic sequencing provide insights into the molecular pathogenesis of PT and help to improve diagnostic accuracy and identify potential drug targets in malignant PT.

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“…2,10 There is also evidence that 1q gain and 4q12 gain may be associated with recurrent disease in malignant phyllodes tumors. 11 The diagnosis of phyllodes tumors and the assignment of a grading based on histologic characteristics are still associated with much uncertainty and variability.…”

Section: Discussionmentioning

confidence: 99%

Malignant Phyllodes Tumors of the Breast: A Study in Clinical Practice

Majeski¹,

Stroud²

2012

International Surgery

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Malignant phyllodes tumors are an uncommon breast tumor in clinical practice of surgery. The study population consisted of five consecutive patients. Each patient had complete clinical follow-up with annual mammograms and physical examination in a specialized breast clinic. They were surgically treated for with malignant phyllodes tumor of the breast. All patients are alive and well with a complete follow-up. The first 2 patients had a fine needle aspiration cytology and were surgically treated by a simple mastectomy. The remaining 3 patients were preoperatively diagnosed with core needle biopsy. These 3 patients were treated with a wide excision of the phyllodes tumor with at least a 1-cm margin of normal breast tissue. Mammography was 100% accurate in demonstrating a dense breast mass. In each patient ultrasound suggested heterogeneous internal echoes present in each malignant phyllodes tumor. Fine needle aspiration cytology was of no value in the diagnosis of a phyllodes tumor. Core needle biopsy is highly reliable in establishing a preoperative diagnosis. The most helpful clinical observation of a malignant phyllodes tumor was rapid growth and enlargement, which is frequently noted by the patient.

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Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study

Cited by 36 publications

References 22 publications

Borderline and malignant phyllodes tumors display similar promoter methylation profiles

Borderline and malignant phyllodes tumors display similar promoter methylation profiles

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates

Malignant Phyllodes Tumors of the Breast: A Study in Clinical Practice

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