Chromosomal Aberrations in Cattle

Holečková, Beáta; Schwarzbacherová, Viera; Galdíková, Martina; Koleničová, Simona; Halušková, Jana; Staničová, Jana; Verebová, Valéria; Jutková, Annamária

doi:10.3390/genes12091330

Cited by 20 publications

(20 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Likelihood ratio and Pearson chi square values were not calculated and their values were 0 as shown in Table (1). Table 1: Goodness-of-fit tests for initial examination of the model.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Log-linear Model for Describing the Relationship between Chromosomal Aberrations and Infertility Problems in Holstein-Friesian Cows

Abdallah

2022

Zagazig Veterinary Journal

View full text Add to dashboard Cite

Log-linear analysis is widely applied in different scientific research areas, such as its use in veterinary medicine. The objective of this study is to model the relationship between chromosomal aberrations and some diseases in different groups of Holstein-Friesian cows arranged in a contingency table using log linear model. The variables under study were chromosomal aberrations (structural and numerical) and groups of animals with normal (control) and abnormal states. The SPSS statistical package was used for analyzing the data. The results showed that the saturated model significantly fitted the data. The likelihood ratio statistic was 421.023 with a P-value of 0.000, indicating that two-way interactions (group of animals × chromosomal aberrations; group of animals × disease status; and chromosomal aberrations × disease status) have a highly significant effect and are good predictors in the model. The threeway interaction (group of animals, chromosomal aberrations, and disease status) was not significant (P-value = 0.858), so it was eliminated. After backward elimination statistics, it is found that all two-way interactions (group of animals × chromosomal aberrations, group of animals × disease status and chromosomal aberrations × disease status interactions) should not be deleted from the model to avoid model distortion. The total diseased animals compared to total non-diseased ones are both more likely to be grouped where odds ratio = 1.45 with 95% CI (1.549 -1.360) and be supposed to have chromosomal aberrations. This model was the best fit model because it showed all possible effects, including main effects, interaction effects between each two variables, and interaction effects between the three variables.

show abstract

“…Likelihood ratio and Pearson chi square values were not calculated and their values were 0 as shown in Table (1). Table 1: Goodness-of-fit tests for initial examination of the model.…”

Section: Resultsmentioning

confidence: 99%

“…It is known that the relationship between chromosomal aberrations and reproductive disorders in livestock is of great importance, so it has been studied for many years [1]. Studying and modelling these relationships depends on using different statistical methods of categorical data analysis.…”

Section: Introductionmentioning

confidence: 99%

Log-linear Model for Describing the Relationship between Chromosomal Aberrations and Infertility Problems in Holstein-Friesian Cows

Abdallah

2022

Zagazig Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Indeed, arguably the best known non-human chromosome abnormality in all of the scientific literature is a Robertsonian translocation (RobT) of the largest and smallest cattle autosomes (1:29). This specific abnormality has been observed in over 50 breeds around the world, with reported frequencies varying from up to 60% to as low as 0.4% in Holsteins [ 10 ]. As with any balanced translocation, the phenotypic effects are rarely seen in the animal itself, but manifested in its subsequent reproductive performance, largely because of perturbations of the normal meiotic process, leading to a reduction in the number of gametes produced, and chromosomal unbalanced products that can lead to implantation failure and/or pregnancy loss [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the 1:29 RobT, over 44 other similar errors (also RobTs) have been observed and described in cattle, with equivalent negative effects on fertility [ 9 ]. These additional RobTs have a lower reported incidence rate: in general, around 6.5% in Holstein cattle; however, this number varies with other breeds [ 10 ]. It is possible, however, given the difficulty in identifying individual chromosomes, that some RobTs are identified as 1:29, when in fact they involve other chromosomes.…”

Section: Introductionmentioning

confidence: 99%

The Economic Burden of Chromosome Translocations and the Benefits of Enhanced Screening for Cattle Breeding

Lewis

Canedo-Ribeiro

Rathje

et al. 2022

Animals

View full text Add to dashboard Cite

The cattle breeding industry, through both of its derivatives (dairy and beef), provides 81% of milk and 22% of meat required globally. If a breeding bull is sub-fertile, this impacts herd conception and birth rates, and it is generally accepted that having a proactive genetic screening programme can prevent further losses. Chromosome translocations are the leading genetic cause of infertility in livestock and, in cattle, this extends beyond the classical 1:29 to other Robertsonian translocations (RobTs) and to reciprocal translocations (RECTs). The incidence of both (collectively termed RTs) varies between breeds and herds; however, we estimate that RECTs are, most likely, at least twice as common as RobTs. The purpose of this study was to develop an industry economic model to estimate the financial impact of an RT event at the herd level. If we assume a conservative incidence rate of 0.4% for Rob1:29 with each one impacting the conception rate by 5%, we calculate that actively screening for and removing a Rob1:29 bull could benefit an impacted herd by GBP 2.3 million (approx. USD 2.8 million) over six years. A recently updated screening protocol developed in our lab for all RTs, however (with a projected combined incidence of 1.2%, impacting conception rates by 10%), could benefit an impacted herd by GBP 7.2 million (nearly USD 9 million) for each RT found. For an industry worth USD 827.4 billion (dairy) and USD 467.7 billion (beef), expanding knowledge on incidence and further dissection of the potential costs (financial and environmental) from RTs is essential to prevent further losses.

show abstract

“…Autosomal aneuploidies are equally rare in other domestic species. There are 16 reported cases of autosomal trisomies in cattle involving the 10 smallest autosomes, typically resulting in fetal death or postnatal culling by breeders due to congenital defects [ 8 , 9 ]. In the domestic pig, there are no reports of live-born animals with whole autosome aneuploidies [ 10 ], and all autosomal trisomies in dogs have exclusively been found in tumor cells [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Second Case of Non-Mosaic Trisomy of Chromosome 26 with Homologous Fusion 26q;26q in the Horse

Ghosh

Kjöllerström

Metcalfe

et al. 2022

Animals

View full text Add to dashboard Cite

We present cytogenetic and genotyping analysis of a Thoroughbred foal with congenital neurologic disorders and its phenotypically normal dam. We show that the foal has non-mosaic trisomy for chromosome 26 (ECA26) but normal 2n = 64 diploid number because two copies of ECA26 form a metacentric derivative chromosome der(26q;26q). The dam has normal 64,XX karyotype indicating that der(26q;26q) in the foal originates from errors in parental meiosis or post-fertilization events. Genotyping ECA26 microsatellites in the foal and its dam suggests that trisomy ECA26 is likely of maternal origin and that der(26q;26q) resulted from Robertsonian fusion. We demonstrate that conventional and molecular cytogenetic approaches can accurately identify aneuploidy with a derivative chromosome but determining the mechanism and parental origin of the rearrangement requires genotyping with chromosome-specific polymorphic markers. Most curiously, this is the second case of trisomy ECA26 with der(26q;26q) in the horse, whereas all other equine autosomal trisomies are ‘traditional’ with three separate chromosomes. We discuss possible ECA26 instability as a contributing factor for the aberration and likely ECA26-specific genetic effects on the clinical phenotype. Finally, because ECA26 shares evolutionary homology with human chromosome 21, which trisomy causes Down syndrome, cytogenetic, molecular, and phenotypic similarities between trisomies ECA26 and HSA21 are discussed.

show abstract

Chromosomal Aberrations in Cattle

Cited by 20 publications

References 84 publications

Log-linear Model for Describing the Relationship between Chromosomal Aberrations and Infertility Problems in Holstein-Friesian Cows

Log-linear Model for Describing the Relationship between Chromosomal Aberrations and Infertility Problems in Holstein-Friesian Cows

The Economic Burden of Chromosome Translocations and the Benefits of Enhanced Screening for Cattle Breeding

The Second Case of Non-Mosaic Trisomy of Chromosome 26 with Homologous Fusion 26q;26q in the Horse

Contact Info

Product

Resources

About