Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers

Philipp, Ute; Quignon, Pascale; Scott, A.; André, Catherine; Breen, Matthew; Leeb, Tosso

doi:10.1093/jhered/esi079

Cited by 11 publications

(11 citation statements)

References 15 publications

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“…Therefore analyzing the canine ortholog of the Mlph gene causing this mutant in mice seemed a logical approach to elucidate the molecular basis for coat color dilution in dogs. The assignment of the canine MLPH gene to CF25q24 is in accordance with the location of the human and murine orthologous genes and with the known synteny data of the integrated canine map [11,12]. The orientation of the MLPH and COL6A3 genes to each other is also consistent with their orientation on the human map.…”

Section: Discussionsupporting

confidence: 78%

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

et al. 2005

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Background: Pinschers and other dogs with coat color dilution show a characteristic pigmentation phenotype. The fur colors are a lighter shade, e.g. silvery grey (blue) instead of black and a sandy color (Isabella fawn) instead of red or brown. In some dogs the coat color dilution is sometimes accompanied by hair loss and recurrent skin inflammation, the so called color dilution alopecia (CDA) or black hair follicular dysplasia (BHFD). In humans and mice a comparable pigmentation phenotype without any documented hair loss is caused by mutations within the melanophilin gene (MLPH).

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Section: Discussionsupporting

confidence: 78%

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

et al. 2005

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“…Many of these clones, which were FISH mapped to determine their cytogenetic location, contained genes associated with disease (e.g. van de Sluis et al, 1999Sluis et al, , 2001Wagner et al, 1999;Thomas et al, 2001a;Lozier et al, 2002;Rak et al, 2002Rak et al, , 2003van den Berg et al, 2003van den Berg et al, , 2004Wagner, 2003;Klukowska et al, 2004a, b;Stabej et al, 2004Stabej et al, , 2005Debenham et al, 2005;Philipp et al, 2005; also see http://faculty.vetmed.ucdavis. edu/Faculty/lalyons/Sites/CompGenBACsDOG.htm) and cancer (Thomas et al, 2003a, b).…”

Section: The Role Of Canine Molecular Cytogenetics In Genome Mappingmentioning

confidence: 99%

Canine cytogenetics – from band to basepair

Breen

2008

Cytogenet Genome Res

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Humans and dogs have coexisted for thousands of years, during which time we have developed a unique bond, centered on companionship. Along the way, we have developed purebred dog breeds in a manner that has resulted unfortunately in many of them being affected by serious genetic disorders, including cancers. With serendipity and irony the unique genetic architecture of the 21st century genome of Man’s best friend may ultimately provide many of the keys to unlock some of nature’s most intriguing biological puzzles. Canine cytogenetics has advanced significantly over the past 10 years, spurred on largely by the surge of interest in the dog as a biomedical model for genetic disease and the availability of advanced genomics resources. As such the role of canine cytogenetics has moved rapidly from one that served initially to define the gross genomic organization of the canine genome and provide a reliable means to determine the chromosomal location of individual genes, to one that enabled the assembled sequence of the canine genome to be anchored to the karyotype. Canine cytogenetics now presents the biomedical research community with a means to assist in our search for a greater understanding of how genome architectures altered during speciation and in our search for genes associated with cancers that affect both dogs and humans. The cytogenetics ‘toolbox’ for the dog is now loaded. This review aims to provide a summary of some of the recent advancements in canine cytogenetics.

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“…Heavily clumped melanin is present in the epidermis, dermis and hair follicles. Disease may be accompanied by recurrent bacterial infections of the hair follicles (folliculitis) (Kim et al, 2005;Philipp et al, 2005b). Canine black hair follicular dysplasia (BHFD) is a rare disorder confined to black coat regions affecting bicolour or tricolour animals within the first few weeks of life (von Bomhard et al, 2006).…”

Section: Introducionmentioning

confidence: 99%

Detection of MLPH gene polymorphism in population of the Belgian Shepherd variety Malinois

Dudasova¹,

Miluchová²,

Gábor³

2021

JCEA

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Melanophilin (MLPH) gene affects dilution of coat colour. It focuses on D locus alleles and in c.-22G>A polymorphism 2 alleles were described. Dominant D allele controls regular colour whereas recessive d allele causes dilution. Diluted colouration in Belgian Shepherd variety Malinois is undesirable and excluded from breeding. Dilution of the coat colour can sometimes be accompanied by skin disease (CDA or BHFD). Methods of molecular genetics including PCR-RFLP method were used to identify c.-22G>A polymorphism in MLPH gene. Within the analysed population of 56 dogs following genotypes were discovered: 50 dogs with homozygous DD genotype, i.e. 89.29% frequency of occurrence and 6 dogs with heterozygous Dd genotype, i.e. 10.71% frequency of occurrence.

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Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers

Cited by 11 publications

References 15 publications

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

Canine cytogenetics – from band to basepair

Detection of MLPH gene polymorphism in population of the Belgian Shepherd variety Malinois

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